In this episode, we dive into the clinical nuances of using gabapentin and pregabalin for chronic neuropathic pain. Join us as we unpack the evolving approach to gabapentinoid prescribing, including key pharmacologic differences, practical dose limitations, and when to consider switching therapies. Learn why doses of gabapentin above 1800 mg/day may not provide added benefit...and how pregabalin’s consistent absorption and greater binding affinity might offer an effective alternative, even with cost considerations. Whether you're a clinician or simply curious about pain management, this episode brings evidence-based insights to the forefront.