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Podovirus
Jessica Sacher and Joseph Campbell
13 episodes
2 weeks ago
Phages (bacteriophages) are viruses that kill bacteria with sniper-like precision. They can be incredibly useful for treating life-threatening infections ('phage therapy'), and can help us reduce our dependence on antibiotics. They've been known for 100 years... so WHY do we still not see them on the shelves? Jessica Sacher, PhD (Staff Scientist at Stanford and cofounder of Phage Directory) and Joseph Campbell, PhD (former NIAID program officer) talk to phage therapy practitioners, researchers and entrepreneurs to understand one question: why don't we have phage therapy yet?
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Life Sciences
Science
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All content for Podovirus is the property of Jessica Sacher and Joseph Campbell and is served directly from their servers with no modification, redirects, or rehosting. The podcast is not affiliated with or endorsed by Podjoint in any way.
Phages (bacteriophages) are viruses that kill bacteria with sniper-like precision. They can be incredibly useful for treating life-threatening infections ('phage therapy'), and can help us reduce our dependence on antibiotics. They've been known for 100 years... so WHY do we still not see them on the shelves? Jessica Sacher, PhD (Staff Scientist at Stanford and cofounder of Phage Directory) and Joseph Campbell, PhD (former NIAID program officer) talk to phage therapy practitioners, researchers and entrepreneurs to understand one question: why don't we have phage therapy yet?
Show more...
Life Sciences
Science
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Getting phage research funded — Joe Campbell reflects on a career at NIAID
Podovirus
46 minutes 5 seconds
1 year ago
Getting phage research funded — Joe Campbell reflects on a career at NIAID

Welcome to the Podovirus podcast, episode 2! In this episode, Jessica talks with Dr. Joe Campbell, who recently retired as a program officer at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). Joe played a key role in shaping phage research funding and policy during his tenure at NIAID. He reflects on his career, the evolution of phage therapy research, and shares insights into the grant application process. Takeaways - Phage therapy funding at NIAID has evolved over time; it used to be lumped in with antibiotics, but Joe and his colleague Jane Knisely at NIAID eventually spearheaded the creation of phage-specific grants, which had phage people on their study sections! - Phage therapy centers, such as Phage Canada and Phage Australia, play a key role nowadays in providing personalized phage treatments for patients who don't fit the criteria for traditional clinical trials. - Rigorous clinical trials are essential for demonstrating the efficacy of phage therapies and gaining support from governments and healthcare systems. - Phage therapy has the potential to treat a wide range of infections, and Joe is optimistic that clinical trials will show positive results Chapters 00:00 Introduction 01:24 Reflections on a Career in the Phage Field 06:18 The Evolution of Phage Therapy Funding at NIAID 10:53 Taking Action to Support Phage Grants 14:09 The Impact of Phage Grants on Research and Funding 20:41 The Role of Phage Therapy Centers 22:47 Balancing Phage Therapy Centers and Biotech Companies 28:25 Challenges in Developing Phage Therapies in the US Healthcare System 30:41 The Importance of Rigorous Clinical Trials for Phage Therapies 33:38 NIAD's Preclinical Services for Phage Therapy Development 34:57 Pseudomonas Mouse Models and In Vitro Assays 37:09 The Role of NIAD Program Officers 38:46 Addressing the Economic Challenges of Phage Therapy

Podovirus
Phages (bacteriophages) are viruses that kill bacteria with sniper-like precision. They can be incredibly useful for treating life-threatening infections ('phage therapy'), and can help us reduce our dependence on antibiotics. They've been known for 100 years... so WHY do we still not see them on the shelves? Jessica Sacher, PhD (Staff Scientist at Stanford and cofounder of Phage Directory) and Joseph Campbell, PhD (former NIAID program officer) talk to phage therapy practitioners, researchers and entrepreneurs to understand one question: why don't we have phage therapy yet?