What is it?

• Colorectal cancer
• 3rd most diagnosed cancer in US (men & women)
• S/S = blood in stool, GI irritation, irregular stools, chronic diarrhea, sudden weight loss
• Diagnostic = colonoscopy – polyps, inflammation, ulcers, abnormal growths
• ACS testing guidelines
  • Asymptomatic, negative family history, no polyps – every 10 years
  • Low-risk polyps – 5 years
  • High-risk polyps

What causes it?

• Cause
  • Age (90% of cases for people > 50 y/o)
  • Family history
  • Race – African Americans (new Dx 20% higher in Blacks, and death rates 40% higher)
  • Ethnicity – Ashkenazi Jews
  • Ulcerative colitis, Crohn’s disease
  • Low whole grain diets
  • Genetic predisposition
  • Smoking, alcohol use, lack of exercise, diabetes

How is it treated?

• Stage O, I -- Sx
• Stage II – Sx + Adj Chemo
• Stage III – Sx + Adj Chemo
• Stage IV – Sx + Chemo
  • Chemo + Targeted Tx
  • Gene types – + immunotherapy
  • Radiation

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