The well-being economy framework provides a comprehensive lens to analyse the intersection of economic, social, and ecological sustainability, ensuring the well-being of people and the planet both now and for future generations. The commercial determinants of health offer a key area where the well-being economy framework can be applied to guide decision-making. Industries such as tobacco, alcohol, gambling, and the production of highly processed foods illustrate how economic interests can conflict with long-term social and ecological sustainability. While these industries generate employment and tax revenues, they impose significant costs on public health, healthcare systems, and environmental sustainability. The well-being economy framework allows for a more holistic assessment of these industries, encouraging policymakers to look beyond immediate economic benefits and consider the broader implications for public health and environmental well-being. By integrating commercial determinants of health into decision-making, governments can design policies that mitigate harmful industry practices while promoting economic activities that align with long-term societal well-being. This seminar was delivered by Professor Heikki Hiilamo on 25 March 2025.