Helen Macdonald and Juan Franco are back, delving into some new evidence.   Studies showing that bi-annual injection that could prevent HIV transmission sound incredible, but will the implementation research find that the tried and tested pill regime is better? Jen Manne-Goehler, Assistant Professor of Medicine at Brigham and Women's Hospital, explains all about Lenicaprovir .   And while silicon valley tells us the future is AI, how can we trust the tools they produce? FUTURE-AI is an acronym and a potential answer, Karim Lekadir, director of the University of Barcelona’s Artificial intelligence in medicine lab, join us to explain what FUTURE-AI means, and why its principles are important in both the design and evaluation of machine learning.   Reading list:   HIV: Breakthrough study raises hopes of effective prevention if drug’s costs can be lowered.  FUTURE-AI: International consensus guideline for trustworthy and deployable artificial intelligence in healthcare.