Summary In this episode of the Bioinformatics Lab Podcast, Kevin Libuit and Andrew Page discuss the ongoing H5N1 outbreak, its implications for public health, and the economic impact on agriculture. They explore the nature of avian influenza, the risks of mammalian spillover, and the importance of genomic surveillance in understanding and combating the virus. The conversation highlights the rapid advancements in vaccine development and the need for ongoing monitoring to prevent future outbreaks. Takeaways H5N1 is a highly pathogenic avian influenza affecting poultry and cattle. Influenza viruses are adept at recombining, posing pandemic risks. The current H5N1 outbreak has significant economic impacts on U.S. agriculture. Mammalian spillover from birds to cattle raises public health concerns. Surveillance data is crucial for understanding the spread of H5N1. Genomic sequencing aids in vaccine development and monitoring mutations. Pasteurization is vital in preventing the spread of H5N1 through dairy products. The economic impact of H5N1 in the U.S. is already over a billion dollars. Public health risks from H5N1 remain low but could increase with mutations. Collaboration between public health labs and tech communities is essential for effective response.