In this compelling episode of the College of Glycation podcast, Dr. Paul Reynolds unpacks the overlooked but powerful link between glycation—the sugar-driven chemical reaction happening inside all of us—and the development of cancer. Building on our ongoing exploration of AGEs, oxidative stress, and metabolic dysfunction, Dr. Reynolds explains how chronically elevated blood sugar and the accumulation of advanced glycation end-products ignite inflammation, damage DNA, disrupt cellular signaling, and ultimately create conditions where cancer can thrive. From the AGE–RAGE pathway to insulin resistance and metabolic syndrome, he breaks down the biochemical cascade that turns everyday dietary sugars into silent contributors to tumor growth.

Drawing from cutting-edge research on breast, colorectal, and liver cancers, Dr. Reynolds highlights the growing evidence that dietary AGEs and modern food preparation methods are shaping cancer risk worldwide. He also offers practical strategies to lower AGE exposure, improve metabolic health, and reduce inflammation through nutrition, lifestyle, and smarter cooking techniques. Whether you're passionate about preventative health or simply curious about how metabolism influences disease, this episode delivers an eye-opening look at how sugar affects far more than just our waistlines—and what you can do to protect yourself.