John Murdoch awakens alone in a strange hotel to find that he is in a crime scene. The problem is that he can't remember a thing. For one brief moment, he is convinced that he has gone completely mad. Murdoch sets out to unravel the twisted riddle of his identity. As he edges closer to solving the mystery, he stumbles upon a fiendish underworld controlled by a group of ominous beings collectively known as the Strangers.