Have you ever wondered how we ensure the safety of the medications we take? This podcast delves into the crucial area of drug-induced liver injury, a serious concern in healthcare and drug development. We explore the challenges of current testing methods and spotlight innovative research using a sophisticated 3D human liver model that mimics our body's complexity. Discover how scientists are using this cutting-edge technology to understand why some drugs can unexpectedly harm the liver, as was the case with trovafloxacin, and how this compares to seemingly safer alternatives like levofloxacin. Learn about the intricate mechanisms of drug toxicity, from inflammatory responses to cellular stress, and how this advanced model offers a more reliable way to detect potential dangers before they reach patients, promising a future of safer medicines and reduced animal testing.