In episode 29 of the Interventional Endoscopist Podcast, join us for an insightful conversation with Dr. Legett from the Mayo Clinic, Rochester. We delve into his extensive experience in treating esophageal disorders, focusing on Barrett's esophagus. Dr. Legett shares his journey and training at Mayo Clinic, highlighting his expertise in leveraging artificial intelligence and precision medicine, such as the TissueCypher test, to enhance early detection and management of Barrett's esophagus and esophageal cancer. The episode explores the challenges of diagnosing dysplasia, the transformative potential of AI in standardizing pathology, and improving patient care. Additionally, we discuss the role of molecular profiling in risk stratification and emphasize the critical need for ongoing research to optimize management strategies for Barrett's esophagus. This episode is proudly sponsored by Castle Biosciences, the innovators behind TissueCypher, a test designed to predict esophageal cancer risk in patients with Barrett’s esophagus.