In this episode of the Longevity Game Podcast, your host, Michael Ward, delves into cutting-edge longevity medicine, exploring senolytic compounds, vitamin D, methionine restriction, and calorie restriction trials. The discussion highlights the impact of senescent cells, the role of vitamin D in telomere preservation, and practical lifestyle changes for extending healthspan and lifespan.

Takeaways

-Fisetin and Quercetin are promising natural senolytics.

-Vitamin D acts as a powerful hormone for immunity and telomere preservation.

-Methionine restriction focuses on protein quality to reduce oxidative load.

-Calorie restriction is proven to slow biological aging markers.

-Time-restricted feeding and intermittent fasting activate longevity pathways.

-Exercise and stress control are crucial for maintaining long telomeres.

-Sunlight exposure is important for overall health and longevity.

-Lifestyle choices can slow telomere shortening and reverse it slightly.

-Senescent cells, or 'zombie cells,' impact aging and health.

-Balancing protein sources is key to healthy aging.

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Sources/Links:

🧬 Senolytics & Senescent Cell Studies

• Yousefzadeh MJ et al. Fisetin is a senotherapeutic that extends health and lifespan. (2018, Mayo Clinic)👉 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/

• Ellison-Hughes GM et al. First evidence that senolytics are effective at decreasing senescent cell burden in humans. (2020, EBioMedicine / The Lancet)👉 https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(19)30641-3/fulltext

• Kirkland JL et al. Senolytic drugs: from discovery to translation. (2020, J Intern Med.)👉 https://onlinelibrary.wiley.com/doi/10.1111/joim.13141

• Tavenier J et al. Fisetin as a senotherapeutic agent: Evidence and perspectives. (2024, Exp Gerontol.)👉 https://www.sciencedirect.com/science/article/pii/S0047637424000952

• LeLarge V et al. Senolytics: from pharmacological inhibitors to clinical translation. (2024, NPJ Aging)👉 https://www.nature.com/articles/s41514-024-00138-4🥗 Calorie Restriction & Longevity Trials

• Waziry R et al. Effect of long-term caloric restriction on DNA methylation measures of aging: results from the CALERIE trial. (2023, Nature Aging)👉 https://www.nature.com/articles/s43587-022-00357-y

• Flanagan EW et al. Calorie restriction and aging in humans. (2020, PMC)👉 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042193/

• Hastings WJ et al. Effect of long-term caloric restriction on telomere length in humans. (2024, Aging Cell)

👉 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11296136/

☀️ Vitamin D, Telomeres & Biological Aging

• Mass General Brigham (2025): Vitamin D Supplements Show Signs of Protection Against Biological Aging.

👉https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/vitamin-d-supplements-show-signs-of-protection-against-biological-aging

• SciTechDaily (2025): Vitamin D May Help Slow Aging, Study Finds.

👉 https://scitechdaily.com/vitamin-d-may-help-slow-aging-study-finds/🧫 Methionine Restriction Review

• Suda M et al. Targeting cell senescence and senolytics: Novel strategies for healthy longevity. (2024, Endocrinology & Metabolism Reviews)

👉 https://academic.oup.com/edrv/article/45/5/655/7631421📚 Historical Reference

• Hayflick L & Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25(3):585-621.

👉 https://doi.org/10.1016/0014-4827(61)90192-6

#LongevityMedicine #Senolytics #Fisetin #Quercetin #VitaminD #Telomeres #CalorieRestriction #MethionineRestriction #HealthyAging #NextLevelTRT #TheLongevityGamePodcast