Welcome to a new episode of the Pain Matters Podcast, where we dive into the intricate world of pain science with leading expert Professor Lorimer Moseley to explore the concept of pain system hypersensitivity. In our journey through the realms of pain, we encounter terminology that seeks to capture the essence of patients' experiences. One such term, "pain system hypersensitivity," emerges from a meticulous study where patients themselves were asked to articulate their ongoing pain states. In this episode, we unravel the significance of this term, delving into its connections with primary and secondary hyperalgesia, as well as allodynia. The introduction of "pain system hypersensitivity" stems from a profound understanding of patients' perspectives and preferences. As we navigate through this discussion, we will explore how this term reflects the lived experiences of individuals grappling with persistent pain. Interestingly, alternatives like "nociplastic pain" and "oversensitivity" were considered but did not resonate with the patients. Our exploration today aims to shed light on the intricacies of pain system hypersensitivity, offering insights that could reshape our understanding of chronic pain and guide us towards more empathetic and effective approaches to pain management. So, join us on this enlightening journey with Professor Lorimer Moseley as we delve into the nuanced world of pain system hypersensitivity on the Pain Matters Podcast.