Putting sleep deprivation under the microscope yet again, Matt explores our "genetic workforce" of 20,000 genes operating on a precise 24-hour cycle. He details 2013 research showing that just one week of six-hour nights alters 711 genes - three percent of the human genome. This shift disrupts the circadian clock’s coordination, moving the body away from essential repair toward cellular stress and inflammatory markers. Matt also examines the tissue-specific damage of sleep loss, explaining ho...
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Putting sleep deprivation under the microscope yet again, Matt explores our "genetic workforce" of 20,000 genes operating on a precise 24-hour cycle. He details 2013 research showing that just one week of six-hour nights alters 711 genes - three percent of the human genome. This shift disrupts the circadian clock’s coordination, moving the body away from essential repair toward cellular stress and inflammatory markers. Matt also examines the tissue-specific damage of sleep loss, explaining ho...
#117 - Can Creatine & Exercise Overcome Sleep Deprivation?
The Matt Walker Podcast
18 minutes
1 month ago
#117 - Can Creatine & Exercise Overcome Sleep Deprivation?
Matt confronts the systemic failure of sleep deprivation, examining its impact on our biological machinery. When sleep is short, the body's "fuel gauge" dips, impairing mitochondrial function and glucose tolerance. However, he highlights compelling research on two interventions - creatine supplementation and high-intensity interval training. These act as backup generators, offering a physiological buffer to preserve metabolic and executive functions when rest is unavoidably restricted. The ep...
The Matt Walker Podcast
Putting sleep deprivation under the microscope yet again, Matt explores our "genetic workforce" of 20,000 genes operating on a precise 24-hour cycle. He details 2013 research showing that just one week of six-hour nights alters 711 genes - three percent of the human genome. This shift disrupts the circadian clock’s coordination, moving the body away from essential repair toward cellular stress and inflammatory markers. Matt also examines the tissue-specific damage of sleep loss, explaining ho...
