On the eve of World Alzheimer’s Day, Dr. Ennapadam S. Krishnamoorthy hosts Prof. Robert Friedland and Prof. Vincent Mok for a candid deep dive into the gut-brain axis in neurodegeneration. From bacterial amyloids that can cross seed brain proteins, to aquaporin 4, meningeal clearance, oral and ear microbiomes, and why lifestyle and diet still matter, Prof. Friedland challenges the field to think deeper than plaques, asking better questions and looking beyond the gut to mouth, skin, and even earwax.