The use of host modulators represents a true paradigm shift in the way we think about treating inflammatory diseases. In the current episode of the Next Regeneration Podcast, hosts Anina and Elena interview Hatice Hasturk about her pioneering work on specialized pro-resolving lipid mediators (SPMs) for treating periodontal diseases, along with her team. Their approach represents a significant shift in how we handle inflammation, aiming for active resolution rather than suppression. The results of her translational research are promising and suggest that these modulators may not only target local inflammation but also have systemic effects, potentially breaking the link between periodontitis and systemic diseases. It's serious progress in the fight against inflammatory disorders.