The Indian Science Congress (ISC)—the first-ever conclave of India’s scientific community—was inaugurated in 1914. It was conceived by two British chemists, Professor J. L. Simonsen and Professor P. S. MacMahon. The inaugural session was held from January 15 to 17, 1914, under the presidency of Ashutosh Mukherjee, then Vice Chancellor of the University of Calcutta. The event brought together 105 scientists from across India and abroad. For nearly a century, the ISC attracted luminaries from India and the global scientific community. Yet, questions lingered: Was it more pomp than purpose? Critics often argued that the Congress remained a platform for exchanging ideas rather than fostering a scientific temperament among the masses or inspiring students. The 109th edition, scheduled for 2024, never took place. In September 2025, the government formally replaced the ISC with the Emerging Science, Technology and Innovation Conclave (ESTIC)—a clear pivot toward innovation-driven forums. In this episode, we trace the journey of the Indian Science Congress—from its cradle to its grave. Hosts: Sobhana K Nair & Jacob Koshy Recorded by Tayyab Hussain Edited and produced by Jude Francis Weston