In the premier episode of The ReProgram podcast, Dr. George Murphy introduces the concept of reprogramming oneself for resilience against disease and disability. He shares his existential crisis about focusing on disease treatment rather than prevention, leading to a new approach centered on studing dynamic resilience, or our ability to robustly respond to insult and injury. The episode also outlines topics for future discussions, including the history and use of stem cells in regenerative medicine, exceptional longevity and centenarians, and the realities of age reversal.

Keywords

reprogramming, resilience, iPSCs, stem cells, disease prevention, dynamic resilience, centenarians, longevity, regenerative medicine, geroscience, age reversal

Takeaways

• Reprogramming oneself can lead to resilience against disease.
• Focusing on disease prevention is more effective than treatment.
• Centenarians offer insights into exceptional longevity.
• Genes and mechanisms drive resilience to disease.
• Understanding aging is crucial before we can even begin to contemplate age reversal.
• The podcast explores longevity and geroscience.

Office Artifact

On the desk: Avengers Marvel Legends Full Scale Iron Man Electronic Helmet

Chapters

(00:00:00) Introduction to The ReProgram podcast

(00:00:35) The Role of Master Stem Cells in Disease Modeling and Regenerative Medicine

(00:01:58) Existential Crisis and a New Approach to Science and Medicine

(00:04:22) Dynamic Resilience and Longevity

(00:05:16) Future Topics and Explorations