Episode 4 - Caloric Restriction, Metabolism, and Energetics in Health and Disease

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The ReProgram

TheReProgramPodcast

7 episodes

1 week ago

The ReProgram is dedicated to exploring how we can extend the healthy human lifespan through science and self-understanding. Hosted by Dr. George Murphy, each episode dives into the rapidly evolving fields of aging biology, longevity, regenerative medicine, and geroscience. From cellular rejuvenation and advanced therapeutics to lifestyle strategies that build resilience against disease, we examine what the science actually shows—and what it doesn’t. No hype. No myths. Just rigorous, evidence-based conversations about how we can reprogram our biology to live longer and healthier lives.

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Life Sciences

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Episode 4 - Caloric Restriction, Metabolism, and Energetics in Health and Disease

The ReProgram

30 minutes 52 seconds

1 month ago

Episode 4 - Caloric Restriction, Metabolism, and Energetics in Health and Disease

In this episode of the Reprogram Podcast, Dr. George Murphy hosts Dr. Rozalyn Anderson, a leading expert in caloric restriction and metabolism and how they impact healthful aging. They delve into the science of aging, focusing on caloric restriction and its impact on longevity. Dr. Anderson shares her journey from yeast genetics to studying aging in animal models, and finally, to applying what was learned to humans, highlighting the metabolic processes that contribute to aging and how caloric restriction can delay age-related diseases. The discussion also covers the potential of geroprotectors like rapamycin, the possibilities of radical age reversal, and how we should train the next generation of scientists and clinicians.

Keywords

caloric restriction, aging, metabolism, longevity, geroprotectors, rapamycin, geroscience, regenerative medicine, aging biology, gerontology

Takeaways

Caloric restriction is the gold standard for studying longevity interventions.
Metabolism plays a crucial role in aging processes.
Caloric restriction can delay the onset of age-related diseases.
Rapamycin shows promise as a geroprotector.
Energy efficiency is key to metabolic resilience.
Human trials like CALERIE align with animal studies on aging.
Methylation clocks offer insights into biological age.
Functional outcomes are vital in aging research.
Geroprotectors aim to offset age-related conditions.
Collaboration between academia and industry is essential.

Office Artifact

On the desk: The Mongkhon or Muay Thai Headband traditionally worn by Thai martial artist as they enter the ring. Bangkok, Thailand

Chapters

00:00:00 Introduction to Dr. Rozalyn Anderson and Caloric Restriction

00:03:04 Understanding Caloric Restriction

00:06:44 We Are What We Eat!

00:08:38 Caloric Restriction as the “Gold Standard’ of Slowing Aging

00:10:03 Rapamycin as a Longevity Intervention

00:11:30 Exploring Geroprotectors

00:14:48 What is Aging and How Do We Measure It?

00:16:40 Defining Geroprotection and Longevity

00:18:55 The Role of the NIH in Aging Research

00:22:12 Collaboration Between Academia and Industry

00:23:38 The Realities of Age Reversal

00:26:33 Personal Reflections on Aging and Lifestyle

Notes:

The Interventions Testing Program (ITP): https://www.nia.nih.gov/research/dab/interventions-testing-program-itp

The National Institute on Aging: https://www.nia.nih.gov/