Ayush Noori, Ashton Trotman-Grant, Michael Chavez, Seth Bannon
24 episodes
9 months ago
Translation is the process of turning basic scientific research into therapies that cure disease, new sources of energy that heal the planet, and other things that move the world forward.
The Translation Podcast takes a deep dive into scientific advancements with a massive potential to improve society. We talk directly with the people advancing the science with their own hands and minds, and focus on how we can translate the science from the bench to the benefit of all.
Initially centered on biology and synthetic biology, we’ll talk with the most promising young scientists in the field. We aim to demystify the science for a general audience and to shine a light on how great science turns into great business. We hope these discussions will inspire scientists, entrepreneurs, and investors to help commercialize breakthrough research.
If you’re an author of an upcoming paper in biology or know of any interesting papers dropping soon and want to hear from the authors, drop us an email at translation@50y.com.
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Translation is the process of turning basic scientific research into therapies that cure disease, new sources of energy that heal the planet, and other things that move the world forward.
The Translation Podcast takes a deep dive into scientific advancements with a massive potential to improve society. We talk directly with the people advancing the science with their own hands and minds, and focus on how we can translate the science from the bench to the benefit of all.
Initially centered on biology and synthetic biology, we’ll talk with the most promising young scientists in the field. We aim to demystify the science for a general audience and to shine a light on how great science turns into great business. We hope these discussions will inspire scientists, entrepreneurs, and investors to help commercialize breakthrough research.
If you’re an author of an upcoming paper in biology or know of any interesting papers dropping soon and want to hear from the authors, drop us an email at translation@50y.com.
The expression of genes in our genome to produce proteins and non-coding RNAs, the building blocks of life, is critical to enable life and human biology. So, the ability to predict how much of a gene is expressed based on that gene’s regulatory DNA, or promoter sequence, would help us both understand gene expression, regulation, and evolution, and would also help us design new, synthetic genes for better cell therapies, gene therapies, and other genomic medicines in bioengineering.
However, the process by which gene transcription is regulated is incredibly complex; thus, prediction transcriptional regulation has been an open problem in the field for over half a century. In his work, Eeshit used neural networks to predict the levels of gene expression based on promoter sequences. Then, he reverse engineered the model to design specific sequences that can elicit desired expression levels. Eeshit’s work developing a sequence-to-expression oracle also provided a framework to model and test theories of gene evolution.
Translation
Translation is the process of turning basic scientific research into therapies that cure disease, new sources of energy that heal the planet, and other things that move the world forward.
The Translation Podcast takes a deep dive into scientific advancements with a massive potential to improve society. We talk directly with the people advancing the science with their own hands and minds, and focus on how we can translate the science from the bench to the benefit of all.
Initially centered on biology and synthetic biology, we’ll talk with the most promising young scientists in the field. We aim to demystify the science for a general audience and to shine a light on how great science turns into great business. We hope these discussions will inspire scientists, entrepreneurs, and investors to help commercialize breakthrough research.
If you’re an author of an upcoming paper in biology or know of any interesting papers dropping soon and want to hear from the authors, drop us an email at translation@50y.com.
