Ayush Noori, Ashton Trotman-Grant, Michael Chavez, Seth Bannon
24 episodes
9 months ago
Translation is the process of turning basic scientific research into therapies that cure disease, new sources of energy that heal the planet, and other things that move the world forward.
The Translation Podcast takes a deep dive into scientific advancements with a massive potential to improve society. We talk directly with the people advancing the science with their own hands and minds, and focus on how we can translate the science from the bench to the benefit of all.
Initially centered on biology and synthetic biology, we’ll talk with the most promising young scientists in the field. We aim to demystify the science for a general audience and to shine a light on how great science turns into great business. We hope these discussions will inspire scientists, entrepreneurs, and investors to help commercialize breakthrough research.
If you’re an author of an upcoming paper in biology or know of any interesting papers dropping soon and want to hear from the authors, drop us an email at translation@50y.com.
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Translation is the process of turning basic scientific research into therapies that cure disease, new sources of energy that heal the planet, and other things that move the world forward.
The Translation Podcast takes a deep dive into scientific advancements with a massive potential to improve society. We talk directly with the people advancing the science with their own hands and minds, and focus on how we can translate the science from the bench to the benefit of all.
Initially centered on biology and synthetic biology, we’ll talk with the most promising young scientists in the field. We aim to demystify the science for a general audience and to shine a light on how great science turns into great business. We hope these discussions will inspire scientists, entrepreneurs, and investors to help commercialize breakthrough research.
If you’re an author of an upcoming paper in biology or know of any interesting papers dropping soon and want to hear from the authors, drop us an email at translation@50y.com.
Chimeric antigen receptors, or CARs, repurpose the build-in targeting and homing signals of our immune system to direct T cells to find and eliminate cancers. Although CAR-T cells have transformed the care of liquid tumors in the circulating blood, like B cell leukemia and lymphoma, CAR-T therapy has shown limited efficacy against solid tumors. To unlock the full potential of CAR-T therapies, better receptor designs are needed. Unfortunately, the space of potential designs is too large to check one by one. To design better CARs, Dan and his co-author Camillia Azimi developed CAR Pooling, an approach to multiplex CAR designs by testing many at once with different immune costimulatory domains. They select the CARs that exhibit the best anti-tumor response and develop novel CARs that endow the T cells with better anti-tumor properties. Their methods and designs may help us develop therapies for refractory, treatment-resistant cancers, and may enable CAR-T cells to cure infectious diseases, autoimmunity, and beyond.
Translation
Translation is the process of turning basic scientific research into therapies that cure disease, new sources of energy that heal the planet, and other things that move the world forward.
The Translation Podcast takes a deep dive into scientific advancements with a massive potential to improve society. We talk directly with the people advancing the science with their own hands and minds, and focus on how we can translate the science from the bench to the benefit of all.
Initially centered on biology and synthetic biology, we’ll talk with the most promising young scientists in the field. We aim to demystify the science for a general audience and to shine a light on how great science turns into great business. We hope these discussions will inspire scientists, entrepreneurs, and investors to help commercialize breakthrough research.
If you’re an author of an upcoming paper in biology or know of any interesting papers dropping soon and want to hear from the authors, drop us an email at translation@50y.com.
