05: Extended Infusion Beta Lactams for F&N

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Transplant & Oncology ID: Literature Dives

Transplant & Oncology ID

9 episodes

1 week ago

Discover Transplant & Oncology ID: Literature Dives, the podcast dedicated to breaking down the latest research in transplant and oncology infectious diseases in near real-time. Perfect for healthcare professionals, researchers, and enthusiasts, our episodes feature deep dives into groundbreaking studies and evidence-based practices. Stay informed on the cutting-edge science shaping infectious disease management in immunocompromised patients. Follow us to keep up with regular episodes! Created with NotebookLM so there may be mistakes and/or errors.

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05: Extended Infusion Beta Lactams for F&N

Transplant & Oncology ID: Literature Dives

9 minutes 32 seconds

11 months ago

05: Extended Infusion Beta Lactams for F&N

This research article reports on a randomized clinical trial (BEATLE) investigating the efficacy of extended-infusion versus intermittent-infusion β-lactam antibiotics in treating febrile neutropenia in hematological patients. The study, conducted across four Spanish hospitals, aimed to determine if extended infusion improved treatment success, defined as defervescence without antibiotic changes. Results showed no significant difference in treatment success between the two groups. However, extended infusion achieved higher pharmacokinetic/pharmacodynamic targets for susceptible Pseudomonas aeruginosa. The authors conclude that extended infusion isn't routinely warranted but may benefit patients with infections caused by less susceptible microorganisms.

Created with NotebookLM by Google so there may be mistakes and/or errors.

PMID: 39433124

Laporte-Amargos J, Carmona-Torre F, Huguet M, et al. Efficacy of extended infusion of β-lactam antibiotics for the treatment of febrile neutropenia in haematologic patients (BEATLE): a randomized, multicentre, open-label, superiority clinical trial. Clin Microbiol Infect 2024;S1198-743X(24)00488-9.