-Title: Advancing Patient Monitoring, Diagnostics, and Treatment Strategies for Transplant Precision Medicine This is part two in a three-part webinar series based on recent Clinical Series publications in The Lancet on Solid Organ Transplantation: 🔗 https://www.thelancet.com/series-do/o... This webinar series is a collaboration between The Lancet, The Transplantation Society (TTS), the American Society of Transplantation (AST), and the European Society for Organ Transplantation (ESOT). Featuring: Jennifer Li (Chair), Australia – TTS Education Co-Chair Peter Reese (Organizer), United States Marta Sablik (Panelist), France Alexandre Loupy (Panelist), France Overview: Transplant medicine faces substantial challenges, as patients require lifelong immunosuppression to prevent graft rejection. Immunosuppressive regimens to date, while reasonably effective at preventing acute rejection, cause numerous health complications, compromising quality of life and patient survival. A shift towards personalised immunosuppression is needed to improve allograft health, reduce long-term adverse effects, and optimise post- transplant outcomes. This necessity has driven advancements in post-transplant monitoring and diagnostics. Innovative monitoring biomarkers and novel diagnostic modalities have been developed to advance transplant care, with many showing promise for widespread clinical implementation. With advances in artificial intelligence, algorithms have the potential to integrate multidimensional data on the immune system and allograft health, offering a comprehensive view of transplant status. This Series paper highlights the state of post-transplant immunosuppression, monitoring, and diagnostics, emphasising the transformative role of emerging innovations to personalise both allograft and patient care. Their implications could extend to xenotransplantation, further broadening their potential to redefine transplant medicine. Learning Objectives: - Understand the current challenges and limitations associated with lifelong immunosuppression in transplant recipients - Have an overview of the recent advancements in post-transplant monitoring tools and diagnostic biomarkers, with a focus on their clinical potential for personalizing immunosuppressive regimens - Outline future research priorities necessary to validate, standardize, and implement innovative diagnostic strategies in routine transplant clinical practice - Outline the emerging role of artificial intelligence in transplant medicine, including how it may be used to integrate complex immunological and clinical data to enhance graft monitoring and decision-making For more information visit the 🔗 Webinar Homepage: https://tts.org/lancet1 About the Series: Solid organ transplantation offers tremendous benefits for patients with end-stage organ disease. However, key challenges persist: organ shortages, immunosuppression-related toxicities, and inequities in access. This Lancet Clinical Series explores opportunities to address these issues: Upcoming Webinars: Part 1 – July 7, 2025 Scientific Advances in the Assessment, Modification, and Generation of Transplantable Organs for Patients with End-stage Organ Diseases View recording: https://tts.org/lancet1 Part 3 – July 25, 2025 Policy Innovations to Advance Equity in Solid Organ Transplantation More details and registration: https://tts.org/lancet3