On the precipice of reigning over a united Spain, Juana of Castile was instead locked up by a series of men for her supposed "madness". Her tragic tale leads us through the history of research into depression, the neurobiological effects of social isolation, and the misconceptions about the impact of mental illness on one's ability to lead.

Plus: Stefanie sings again. We misgender Fox. Disney needs to answer for "Confessions of a Teenage Drama Queen". You all won't let the Richard discourse die. And how crazy do men like their women, really?