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Episode 1. “It may not make as much sense to say that someone has HLH as it might to say that they are in HLH.” Scott Canna joins Michael Jordan to explore secondary HLH/MAS from a rheumatology perspective – from clinical definitions to treatment strategies – and why reframing HLH as a state rather than a diagnosis could change clinical thinking. The episode also delves into the role of Epstein–Barr virus (EBV) in triggering HLH and how to manage it effectively.