In this episode, VJDementia are joined by Amy Lloyd, PhD, Soyon Hong, PhD, João Pedro Ferrari-Souza, MD-PhD student, & Elina Svensson, PhD student, who share their work looking at the roles of microglia in health and disease, and the implications of this for understanding how to treat Alzheimer's disease. Discussing TREM2 therapeutic targeting, the role of APOE4 in microglial reactivity, proteomic profiling, & what causes microglia to destroy functional synapses in disease.