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New biomarkers are needed that are sensitive to subtle changes, to improve diagnosis and disease monitoring in frontotemporal dementia (FTD). Martina Bocchetta, PhD, University College London, London, UK; Annakaisa Haapasalo, PhD, University of Eastern Finland, Joensuu, Finland; and Adolfo Garcia, PhD, University of San Andrés, Buenos Aires, Argentina, discuss the development of novel biomarkers for FTD.