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This podcast will provide an overview of the importance of synapses in Alzheimer's disease (AD) presented at the AD/PD 2022 and ARUK 2022 meetings. Discover the thoughts of leading authorities Afia Ali, PhD, UCL School of Pharmacy, University College London, London, UK; Makis Tzioras, PhD, The University of Edinburgh, Edinburgh, UK; and Thomas Südhof, MD, Stanford University School of Medicine, Stanford, CA – as they discuss the significance of synapses in AD.