In this podcast episode, leading experts provide valuable insight into the management of sickle cell disease (SCD). First, Samah Babiker, MBBS, MRCP-UK, FRCPath, Evelina London Children’s Hospital, London, UK, and Payal Desai, MD, Levine Cancer Institute & Wake Forest School of Medicine, Charlotte, NC, discuss the challenges associated with the transition from pediatric to adult care and how to support patients through this period. Following this, Enrico Novelli, MD, MS, University of Pittsburgh, Pittsburgh, PA, shares insight into the management of vaso-occlusive crises, and Subarna Chakravorty, MBBS, FRCPath, MRCPCH, PhD, King’s College Hospital NHS Foundation Trust, London, UK, comments on whether MRI brain assessment should be routinely performed in all patients with SCD.