This podcast features updates in chronic lymphocytic leukemia (CLL) from ASH 2025. Talha Munir, MBBS, MRCP, FRCPath, PhD, Leeds Teaching Hospitals NHS Trust, Leeds, UK, discusses the Phase III FLAIR study (ISRCTN01844152), followed by Matthew Davids, MD, Dana-Farber Cancer Institute, Boston, MA, who shares further insights. Carsten Niemann, MD, PhD, Copenhagen University Hospital, Copenhagen, Denmark, shares long-term follow-up results from the GAIA/CLL13 (NCT02950051) trial. Paolo Ghia, MD, Vita-Salute San Raffaele University, Milan, Italy, shares insights into the Phase III ​BELLWAVE-010 study (NCT05947851), followed by Jennifer Woyach, MD, The Ohio State University, Columbus, OH, who discusses Phase I results (NCT04775745) of a novel BTK inhibitor rocbrutinib. Finally, Chan Cheah, MBBS, FRACP, FRCPA, DMSc, Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia, discusses the CaDAnCe-104 trial (NCT06634589) of the BTK degrader BGB-16673, and Barbara Eichhorst, MD, University Hospital Cologne, Cologne, Germany, shares two-year follow-up results from the EPCORE CLL-1 trial (NCT04623541) of epcoritamab monotherapy in Richter’s transformation.