In this podcast, Tiago Outeiro, PhD, University Medical Center Göttingen, Göttingen, Germany; Chia-Chun Chiang, MD, Mayo Clinic, Rochester, MN; and Daniel Goldenholz, MD, PhD, Beth Israel Deaconess Medical Center, Boston, MA, engage in a thought-provoking discussion on the latest developments in AI application. They explore how AI's predictive capabilities could revolutionize basic science, its potential role in the diagnosis and treatment of headache disorders, and the current and prospective uses of AI across different fields of neurology. Join us in this exciting exploration of AI's potential to reshape neurology, its existing successes, and the exciting opportunities it holds for the future.