Anaphylactic shock is a severe, life-threatening form of distributive shock caused by systemic hypersensitivity reactions and massive release of vasoactive mediators. It is characterized by hypotension, airway compromise, bronchospasm, and cutaneous findings such as urticaria and angioedema. In this episode, we break down the pathophysiology of anaphylactic shock, classic clinical presentation, key hemodynamic patterns, and evidence-based management. We focus on early recognition, the critical role of intramuscular epinephrine, airway management, fluid resuscitation, and treatment of refractory shock. We also review how to differentiate anaphylaxis from septic and neurogenic shock, discuss adjunctive therapies, and highlight major guideline recommendations from WAO, AAAAI, and NIAID/FAAN. 📚 MINI COURSES, STUDY GUIDES (for this video), PRACTICE QUESTIONS, AD FREE VIDEOS, EDUCATIONAL DISCUSSIONS in our WBM Emergency Critical Care Patreon Community - Join Today!! https://www.patreon.com/c/WhiteBoardMedicine Playlist on Shock: https://youtube.com/playlist?list=PLf5bMa9_tvRjunk4I-rQZYPZn3qHqWFqW&si=kserFPPm7RYuhul- DISCLAIMER THIS PODCAST DOES NOT PROVIDE MEDICAL ADVICE. The information, including but not limited to, audio, text, graphics, images and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read, watched, or listened to on this video, or any other videos, reports, texts tweets or other sources.