Menopause is a natural physiological process that can diminish quality of life for some women, usually occurring after age 40. Hormone replacement therapy (HRT) can address many of the symptoms of menopause. However, a series of large studies in the early 2000s pointed to increased risks for breast cancer and heart disease, and many providers and women shied away from HRT. William Hurd, M.D., an expert in reproductive endocrinology and infertility, explains the current – revised – state of knowledge about relative risks and benefits of HRT; how the HRT medications themselves have changed since those studies; and how the needle is moving back in favor of HRT for many women seeking to maintain quality of life.