How does a one-millimetre worm help win four Nobel Prizes? In this episode, we explore how C. elegans became one of the most influential organisms in modern biology — not because of its size, but because of its community.
Researchers, beginning with Sydney Brenner’s vision, built an ecosystem of radical openness: shared strains, shared annotations, shared tools, shared knowledge. This culture powered breakthroughs in apoptosis, GFP, RNA interference, and microRNAs, each recognised with a Nobel Prize.
We discuss how the CGC, WormBase, WormAtlas, open imaging libraries, and collaborative genetics transformed a tiny worm into a global scientific powerhouse. It’s the story of a field that chose to share — and in doing so, changed biology.
Key themes:
• The collaborative backbone behind worm research
• Why sharing strains and data accelerated Nobel-winning discoveries
• How open tools shaped genetics, neuroscience, and ageing research
• The social and scientific architecture of a uniquely supportive community
• Why C. elegans is still leading modern multi-omics and connectomics
Based on the research article:🎧 Subscribe to the WOrM Podcast
“From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism”
Victor R. Ambros, Martin Chalfie, Aric L. Daul, Andrew Z. Fire, David H. Hall, H. Robert Horvitz, Craig C. Mello, Gary Ruvkun, Nathan E. Schroeder, Paul W. Sternberg & Ann E. Rougvie.
PNAS (2025)
🔗 https://doi.org/10.1073/pnas.2522808122
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Whole-organism stories from molecules to behaviour.
This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.
📩 More info:
📧 veeren.chauhan@nottingham.ac.uk