Abstract: This research introduces Anthropic Interviewer, an AI-powered tool designed to conduct large-scale qualitative interviews at unprecedented scale while maintaining conversational depth. To validate this methodology, we deployed the system to interview 1,250 professionals—comprising 1,000 general workforce participants, 125 scientists, and 125 creative professionals—about their experiences integrating AI into their work. Results indicate predominantly positive sentiment regarding AI's productivity impact, with 86% of general workforce participants reporting time savings and 97% of creatives noting efficiency gains. However, significant concerns emerged around social stigma (69% of general workforce), professional displacement (55% expressing anxiety), and verification reliability (particularly among scientists). Thematic analysis revealed divergent adoption patterns: general workforce professionals envision AI-augmented supervisory roles; creatives navigate productivity gains against peer judgment and identity concerns; scientists desire AI partnership but withhold trust for core research tasks. This study demonstrates both the viability of AI-mediated qualitative research at scale and provides empirical insight into how professionals across diverse domains are experiencing AI's integration into knowledge work. Learn more about your ad choices. Visit megaphone.fm/adchoices