“49ers Talk” host Matt Maiocco discusses the latest news on Brandon Aiyuk before speaking with coach Kyle Shanahan about San Francisco's Week 12 matchup vs. the Carolina Panthers on Monday night. Also, Greg Papa joins Matt to discuss Brock Purdy’s performance against the Arizona Cardinals in Week 11 and reflect on the trade that brought Christian McCaffrey to the 49ers.

On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan reflect on the blockbuster trade that brought Christian McCaffrey to San Francisco ahead of Monday night's matchup against his former team. Additionally, Matt and Jennifer discuss how a healthy 49ers offense will improve their run game. Matt then sits down with defensive back Deommodore Lenoir to discuss his growth as a leader and team captain of the 49ers’ defense.

Brock Purdy's return sparked the 49ers' offense, it also brought a much needed divisional win in a blowout against the Cardinals. Purdy threw for three touchdowns on Sunday, two of which went to a favorite target in tight end George Kittle and the other went to offensive fulcrum Christian McCaffrey, who leads the NFL in scrimmage yards this season through Week 11. Skyy Moore set the tone, returning the opening kickoff 98 yards to the 1-yard line, setting up a McCaffrey 1-yard touchdown run. San Francisco maintained control throughout the game, one in which Arizona did itself no favors accumulating a franchise-record 17 penalties. San Francisco did not escape Arizona unscathed though, as kicker Eddy Piñeiro suffered a hamstring injury in the third quarter that could force the team to bring in a new kicker. On this episode of '49ers Talk,' co-hosts Matt Maiocco and Jennifer Lee Chan break down San Francisco's outstanding performance against the Cardinals Sunday at State Farm Stadium. Matt and Jennifer discuss the impact of Purdy's return on the 49ers' offense during a crucial stretch, Kittle and CMC's dominance, and how injuries to both Piñeiro and linebacker Tatum Bethune might affect the team ahead of Monday's showdown with the Carolina Panthers.

“49ers Talk” hosts Matt Maiocco and Jennifer Lee Chan provide the latest roster updates before Matt speaks with coach Kyle Shanahan about San Francisco's Week 11 matchup vs. the Arizona Cardinals. Also, Greg Papa joins Matt to discuss Brock Purdy’s return for Sunday’s game and how he could revitalize the Niners for the rest of the season.

Brock Purdy returned to practice Wednesday, taking the 49ers' first-team reps at quarterback with a goal of returning in Week 11 against the Arizona Cardinals. Wide receiver Ricky Pearsall, who, like Purdy, has been missing from San Francisco's starting lineup since Week 4, also returned to the practice field. On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan discuss how the potential return of two impact players will help the 49ers' offense. Additionally, Matt and Jennifer look ahead to how the 49ers can solidify a playoff spot as they approach a pivotal stretch in their schedule. As far as depth is concerned, Matt and Jennifer debate the balance of player development during a postseason push and how to balance two very important pillars to the season.

Matthew Stafford and the Rams' high-powered offense overpowered a 49ers defense reeling from injuries on Sunday, handing San Francisco its first divisional loss with a 42-26 defeat. The 49ers remain locked in the NFC West's third-place spot, fighting for health and positioning as the playoff picture starts to crystallize in the season's second half. On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan break down San Francisco's performance against the Rams in Week 10, from an inexperienced defense decimated by injuries to an offense expected to protect such deficiencies despite its own missing pieces. Matt and Jennifer help make sense of how San Francisco can contend moving forward in a highly competitive divisional and conference environment.

49ers insider Matt Maiocco provides the latest injury updates before speaking with head coach Kyle Shanahan about San Francisco's Week 10 matchup vs. the Los Angeles Rams. Matt also sits down with tight end George Kittle to discuss how he prepares for game day every week, and his love for cinema. Finally Greg Papa joins Matt to discuss key matchups for Sunday’s game and how it is a must-win for the Niners.

The NFL trade deadline came and went Tuesday, and the 49ers stood pat with the roster they have. San Francisco's quiet approach spoke volumes about their intent despite fervor from fans, sticking to their path of growth and development with youth. At 6-3, the 49ers can compete -- and they've decided to do so with the current players at their disposal. On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan discuss San Francisco's choice to trust its depth and chemistry over a splashy trade that would mortgage their future. Also, as Brock Purdy and Ricky Pearsall continue rehabbing their injuries, just how close are they to returning? Finally, Matt and Jennifer debate if the 49ers can strike gold again against the Los Angeles Rams after their rivals' Week 5 theatrics.

The 49ers bounced back in a big way with a statement win over the New York Giants. San Francisco was laser focused in all three phases, never looking back after taking a second-quarter lead. The 49ers' offense was humming all afternoon, scoring a season-high 34 points while Christian McCaffrey added a pair of touchdowns along with 173 total yards. San Francisco's win didn't come without cost, as 2025 first-round draft pick Mykel Williams went down with a knee injury late in the fourth quarter. On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan break down how the 49ers responded to their disappointing loss against the Houston Texans with an offensive outburst in Sunday's win over New York. They also review how Williams' potential loss could affect the 49ers' approach at the NFL trade deadline. Finally, with a pivotal divisional matchup with the Los Angeles Rams looming, Matt and Jennifer discuss Brock Purdy's progress as the quarterback works back from a toe injury.

Matt Maiocco speaks with 49ers coach Kyle Shanahan about San Francisco's Week 9 matchup vs. the New York Giants and how he scripts his first 24 offensive plays. Also, Greg Papa joins Matt to assess the 49ers’ season at the halfway point and discuss key matchups for Sunday’s game.

In need of reinforcements along their injured defensive line, the 49ers made a trade with the New England Patriots for defensive end Keion White and a 2026 seventh-round draft pick in exchange or a 2026 sixth-rounder. Matt Maiocco and Jennifer Lee Chan discuss how White bolsters a 49ers defensive line whose nine sacks are tied for the second-fewest among all NFL teams this season. Matt also sits down with NBC Sports Boston's Patriots insider Phil Perry to examine White's time with the organization as a former second-round pick of the 2023 NFL Draft. Lastly, Jennifer and Matt review if the 49ers would entertain any other trades, assess rookie Mykel Williams' stock through eight games and provide 49ers injury updates before San Francisco's Week 9 game against the New York Giants at MetLife Stadium.

The 49ers came into Week 8 knowing the Texans' defense was elite, but it was Houston's struggling offense that took over Sunday at NRG Stadium. Heavily scrutinized QB C.J. Stroud executed a sound game plan for the Texans, while 49ers teammates George Kittle and Jake Tonges each caught a touchdown on on national Tight Ends Day to keep San Francisco's comeback hopes alive. San Francisco's offense lacked much rhythm beyond that, and the disjointed display effectively ended in a 26-15 loss, their third of the season. On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan break down what went wrong with San Francisco on both sides of the ball, which injuries will further affect the 49ers' depleted depth and how they can turn a performance like this around in Week 9 vs. the New York Giants at MetLife Stadium.

Matt Maiocco sits down with 49ers coach Kyle Shanahan to discuss the team's upcoming Week 8 matchup vs. DeMeco Ryans' Houston Texans. Also, Greg Bethune, father of San Francisco linebacker Tatum Bethune, joins the show to discuss his son's journey to the NFL

Eddy Piñeiro leads the NFL in made field goals without a miss through Week 7, but the 49ers kicker's journey to San Francisco has been anything but perfect. Jennifer Lee Chan sits down with Piñeiro, who shares why he chose to play for the 49ers after Jake Moody's release and how close he came to signing elsewhere. Piñeiro discusses how he brings a jolt to the 49ers' locker room, his fast-growing bond with George Kittle and why football was second to his first love in sport, soccer. Also, Matt Maiocco and Jennifer review the midweek list of 49ers injuries and who might start in Week 8 vs. the Houston Texans.

Without their fearless leader, Fred Warner, the 49ers' defense produced a masterclass performance against the red-hot Atlanta Falcons on Sunday while the offense ran all over the field. Matt Maiocco and Jennifer Lee Chan discuss how San Francisco produced one of its most complete performances this season as players stepped up and embraced the challenge of facing a top opponent. With the return of George Kittle and many backups stepping up, the 49ers proved they might have been down, but they sure aren't out.

Matt Maiocco speaks with 49ers coach Kyle Shanahan about San Francisco's Week 7 matchup against the Atlanta Falcons, and how losing Fred Warner for the season will impact their young defensive players. Also, Jennifer Lee Chan joins the show for an exclusive interview with NBC Sports NFL broadcaster Cris Collinsworth and analyst Devin McCourty to discuss the loss of Warner, Nick Bosa and more.

After a long NFL journey, wide receiver Kendrick Bourne is back with the team who first took a chance on him, and he's beyond grateful for his second 49ers stint. Bourne sits down with '49ers Talk' co-host Matt Maiocco to discuss his path back to San Francisco and how the time away made his return that much sweeter. Bourne details his development over his nine NFL seasons and why he's so happy to be back in the Bay Area. Also, Bourne shares the intricacies of playing wide receiver in Kyle Shanahan's offense and how he values the relationships he has built with fellow teammates like Mac Jones and Ricky Pearsall. Finally, Jennifer Lee Chan and Matt discuss the daunting task of a primetime matchup vs. a surging Atlanta Falcons team and who we could expect to lineup at QB and other key positions in Week 7.

The 49ers' health woes continued after San Francisco lost superstar linebacker Fred Warner to a season-ending ankle injury in Sunday's loss to the Tampa Bay Buccaneers. San Francisco responded valiantly, managing to stay competitive throughout the matchup before fading late in the fourth quarter. Baker Mayfield and the Bucs' high-powered offense proved to be too much in the end as the 49ers suffered their second loss of the season. On this episode of '49ers Talk,' co-hosts Matt Maiocco and Jennifer Lee Chan discuss the potential ramifications of Warner's season-ending injury. They then detail Warner's impact on the 49ers organization from ownership to players and how San Francisco will feel his loss both on and off the field. Finally, they deliberate if Warner's injury signifies the beginning of the end in what started out as a promising 49ers' season?

Matt Maiocco speaks with 49ers coach Kyle Shanahan about San Francisco's Week 6 matchup vs. the Tampa Bay Buccaneers and how rookie defensive lineman Alfred Collins has made significant strides this season. Also Greg Papa joins Matt to discuss what QB3 Adrian Martinez will bring to 49ers' offense if Mac Jones gets injured on Sunday.

Star 49ers running back Christian McCaffrey is off to a hot start offensively this season, showing shades of his 2023 AP Offensive Player of the Year campaign. McCaffrey sits down with Matt Maiocco to discuss a plethora of topics, such as learning route-running from his Super Bowl-winning father, identifying the most valuable asset in professional football and describing how George Kittle helps bring "fun" back into the game. Also, Jennifer Lee Chan stops by to update the 49ers' lengthy injury list and preview the potent Buccaneers offense San Francisco will face in Week 6, led by quarterback Baker Mayfield.