In this episode of the APS Publications Podcast, Dr. Ralph Rühl discusses his team’s new article in Physiological Genomics, “Transcriptome-driven Health-status Transversal-predictor Analysis for health, food, microbiome and disease markers for understanding of lifestyle diseases.” The article outlines the development of a novel artificial intelligence approach based on machine-learning to predict general health and food-intake parameters. This novel technique, which is based on PBMC transcriptomics from human blood, can predict a wide range of health-related markers.   Todt T, van Bussel I, Afman L, Brennan L, Ivanova DG, Kiselova-Kaneva Y, Thomas EL, Rühl R. Transcriptome-driven Health-status Transversal-predictor Analysis for health, food, microbiome and disease markers for understanding of lifestyle diseases. Physiol Genomics. 2025 Nov 19. doi: 10.1152/physiolgenomics.00026.2025. PMID: 41259124.

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education, David Van Reyk discusses their study on "The use of AI large language models by university students for assignment preparation." Over 50% used AI for idea generation and drafting. PRC students showed improvements in their grades with the use of AI, while Australian students’ grades remained unchanged. Students support institutional guidance and access for responsible AI use. The use of AI large language models by university students for assignment preparation Hui Chen, David Van Reyk, and Brian G. Oliver Advances in Physiology Education 2025 49:2, 517-525

In this episode of the APS Publications Podcast, featuring Advances in Physiology Education, coauthors Christine Bell and Oana Birceanu discuss their recently published article, “Educators’ experience and guide to scaffolding generative AI applications throughout a physiology and pharmacology undergraduate laboratory course.” The paper presents a two-pronged approach to reduce GenAI confusion and build AI literacy, research, and critical thinking skills. Educators’ experience and guide to scaffolding generative AI applications throughout a physiology and pharmacology undergraduate laboratory course Christine E. Bell and Oana Birceanu Advances in Physiology Education 2025 49:3, 721-728 

In the latest APS Publications Podcast, featuring Advances in Physiology Education, John Zubek discusses, “From virtual to reality: evaluating student attitudes through VR dissection preparations: a use case.” VR vs. live dissections: how do students learn best? We explored their experiences to see how tech can complement STEM & healthcare training. From virtual to reality: evaluating student attitudes through VR dissection preparations: a use case Sarah Shine, Julia Warznie, Guoli Zhou, and John Zubek Advances in Physiology Education 2025 49:3, 611-620 

In this episode of the APS Publications Podcast, featuring Advances in Physiology Education, coauthors Serena Kuang and Nora Laban discuss their recently published Illuminations paper “From compliance to moduli: clarifying basic mechanical properties of biological tissues.” This article advances physiology education by clarifying the basic mechanical property-related terms in physiology, introducing two fundamental terms in material science that are often missing in physiology education, and revealing the interrelationships among these terms. It serves as a handy tool kit for physiology educators, researchers, as well as clinicians to select and apply these terms appropriately based on their needs. From compliance to moduli: clarifying basic mechanical properties of biological tissues Nora Laban, Radwa Dawood, and Serena Y. Kuang Advances in Physiology Education 2025 49:3, 651-658

In this podcast, coauthors Mary Pelkowski and Gabi Waite discuss their recently published Illuminations article, “Implementing core concept teaching in an integrated, clinical presentation model medical school curriculum”.  They outline a practical approach to incorporating physiology core-concept teaching into an integrated, team-taught medical curriculum—combining a clinical presentation model with flipped classroom learning. Implementing core concept teaching in an integrated, clinical presentation model medical school curriculum Mary M. Pelkowski, Xiaojun Qi-Lytle, and Gabi N. Waite Advances in Physiology Education 2025 49:3, 659-666 

In this podcast, coauthors Maria Magdalena Quetglas-Llabrés and Manuel Jiménez-García discuss their recently published article, ‘Effects of Combining Exercise and Dietary Shifts on Motor Coordination and Oxidative Markers in a High-Fat Diet Model in Rats.' The article investigated the effect of exercise, alone or with dietary modifications, on high fat diet–induced outcomes in rats of both sexes. Authors overview the methodological approach and discuss key takeaways and next steps.   Effects of Combining Exercise and Dietary Shifts on Motor Coordination and Oxidative Markers in a High-Fat Diet Model in Rats Manuel Jiménez-García, Maria Magdalena Quetglas-Llabrés, Maria Del Mar Ribas-Taberner, Antoni Sureda-Gomila, David Moranta-Mesquida, Silvia Tejada-Gavela Comprehensive Physiology 2025;15(6):e70074  https://doi.org/10.1002/cph4.70074 

In this episode of the APS Publications Podcast, featuring Advances in Physiology Education, coauthors Anna Smith, Fran der Weduwen, and Thomas Powell discuss their recently published Illuminations paper “The practical skills passport: a co-curricular program to enhance lab skills confidence in undergraduate neuroscience and biology students”. The COVID-19 pandemic limited in-person lab opportunities, impacting students’ skills and confidence. This episode explores the development, implementation, and evaluation of a co-curricular lab skills program designed to help students regain confidence during their return to in-person learning. Findings show that participation in the program had a positive impact on student lab confidence.   The practical skills passport: a co-curricular program to enhance lab skills confidence in undergraduate neuroscience and biology students Anna E. Smith, Fran der Weduwen, Thomas Powell, and Gayle Doherty Advances in Physiology Education 2025 49:3, 696-703

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education, Prof. S. Mehran Hosseini discusses the study, “Misconception about the application of Dalton’s Law in respiratory physiology.” Dalton’s Law may provide a good example for students to highlight the existence of misconceptions and their effect on gaining new knowledge. The awareness of students about this misconception may improve their learning styles. Misconception about the application of Dalton’s Law in respiratory physiology S. Mehran Hosseini Advances in Physiology Education 2025 49:3, 646-650

In this special episode of the APS Publications Podcast, the founding of Physiological Genomics is discussed in a series of interviews with Drs. Allen W. Cowley, Jr., Bina Joe, and Hilary Coller. These interviews were organized and conducted in September 2025 by Oluwatosin Mautin Akinola (PhD candidate in Molecular Medicine at the University of Toledo, Toledo, OH, United States; https://www.researchgate.net/profile/Oluwatosin-Akinola-2). Full videos of these interviews are available as Supplemental Material in the article. Joe B, Cowley AW, Garrett MR, Kriegel AJ, Prokop JW, Lee EC, Akinola OM, Coller HA. Connecting Genes to Physiology: The First 25 Years of Physiological Genomics. Physiol Genomics. 2025 Oct 29. doi: 10.1152/physiolgenomics.00207.2025. PMID: 41159925.

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education, Dr. Raju Suresh Kumar discusses a novel, hands-on simulation designed to teach auditory physiology. By experiencing unilateral conductive hearing loss, students gain deeper insight into auditory masking and sound lateralization. This simple, cost-effective method enhances conceptual understanding and clinical skills, offering strong potential for integration into medical education. Enhancing auditory physiology: simulating unilateral conduction defects to improve understanding of Rinne’s and Weber’s tests Raju Suresh Kumar, M. Ganesh Kamath, Rekha Prabhu, and Mohamed Eldigire Ahmed Advances in Physiology Education 2025 49:3, 689-695

In this podcast, coauthors Liz Simon, Flavia Souza-Smith, Megan Donovan, Eden Gallegos, Kaitlin Couvillon, and Patricia Molina summarize their recently published review article, "Physiological Mechanisms Vulnerable to Alcohol-Induced Alterations: Role in Chronic Comorbidities." The article describes alcohol's multi-systemic physiological effects on the gastrointestinal, cardiovascular, and immune systems, as well as on energy metabolism that contribute to multiorgan injury and disease burden.   Physiological Mechanisms Vulnerable to Alcohol-Induced Alterations: Role in Chronic Comorbidities Liz Simon, Kaitlin E. Couvillion, Meagan E. Donovan, Eden M. Gallegos, Flavia M. Souza-Smith, Patricia E. Molina Comprehensive Physiology 2025 15:5, e70057   https://doi.org/10.1002/cph4.70057

In this podcast, coauthors Simon D. Pouwels and Brady Rae discuss their recently published research article, "Interorgan Communication Between Lung and Colorectal Epithelial Cells Studied Using a Novel Multi-Organ-On-Chip System." The article describes development of a novel unidirectional millifluidic multi-organ-on-chip device to study the communication between human lung epithelial cells and colorectal cells following a toxic stimulus. Authors additionally discuss the versatility of the device to study communication across other cell types.     Interorgan Communication Between Lung and Colorectal Epithelial Cells Studied Using a Novel Multi-Organ-On-Chip System Brady Rae, Verena Bood, Hye-Jin Dijk, Gwenda F. Vasse, Barbro N. Melgert, Anika Nagelkerke, Janette K. Burgess, Dirk-Jan Slebos, Irene H. Heijink, Simon D. Pouwels Comprehensive Physiology 2025 15:5, e70051 https://doi.org/10.1002/cph4.70051

In this episode of the APS Publications Podcast, featuring an article from AJP–Regulatory, Integrative and Comparative Physiology, author Periklis Marnas discusses inhalation exposure of adult D. melanogaster to cigarette smoke and changes in physiological parameters and the expression of COPD-associated orthologous genes. The study found that transcriptomic responses were more profound in females, indicating sex-specific responses to inhaled toxicants. Furthermore, enrichment analyses of the differentially expressed genes in females pointed to biomolecules associated with response to nicotine and detoxification. D. melanogaster thus provides a powerful model system to test the efficacy of new potential drugs for COPD treatment.   Marnas P, Lüpold S, Giannakou L, Giannopoulos AS, Hatzoglou C, Gourgoulianis KI, Zarogiannis SG, Rouka E. Modeling COPD in Drosophila melanogaster by cigarette smoke inhalation: functional changes and alterations in the expression of COPD-relevant orthologous genes. Am J Physiol Regul Integr Comp Physiol. 2025 Jul 1;329(1):R13-R19. https://doi.org/10.1152/ajpregu.00056.2025

In this episode of the APS Publications Podcast, featuring an article from AJP–Regulatory, Integrative and Comparative Physiology, authors Ziba Taherzadeh and Claire Kissell discuss the influence of race and sex and Cardiac autonomic function. Their study found that non-Hispanic Black adults living in the United States are more likely to develop cardiovascular disease compared with their non-Hispanic White adult counterparts. These results support that reduced cardiac autonomic function does not manifest early in life among young non-Hispanic Black adults, but rather non-Hispanic Black men had greater spontaneous cardiac baroreflex sensitivity and heart rate variability compared with non-Hispanic White men. No differences were found among women.   Taherzadeh Z, Kissell CE, Young BE, Alhalimi TA, Stephens BY, Kaur J, Kao Y, Brothers RM, Fadel PJ. Cardiac autonomic function in young, healthy adults: Influence of race and sex. Am J Physiol Regul Integr Comp Physiol. 2025 May 1;328(5):R611-R618. https://doi.org/10.1152/ajpregu.00288.2024

In this episode of the APS Publications Podcast, featuring an article from AJP–Regulatory, Integrative and Comparative Physiology, authors Andrea Zsombok, Lucie Desmoulins, and Adrien Molinas discuss the role of estradiol treatment in regulating metabolism and glucose homeostasis. In their study with middle-aged, high-fat diet-fed, ovariectomized female mice, the authors found that liver-related neurons in the hypothalamus became more excitable. Estradiol treatment reduced this excitability, suggesting that midlife estradiol therapy may support healthier brain-liver metabolic regulation.   Molinas AJR, Desmoulins LD, Dugas CM, Williams GL, Kamenetsky S, Felintro de Souza V, Maroteaux MJ, Davis RK, Daniel JM, Schrader LA, Zsombok A. Midlife estradiol treatment reduces the firing rate of liver-related PVN neurons in ovariectomized high-fat diet-fed mice. Am J Physiol Regul Integr Comp Physiol. 2025 Aug 1;329(2):R245-R252. https://doi.org/10.1152/ajpregu.00117.2025

In this episode of The APS Publications Podcast, coauthors Matthew A. Hadiono, Alexis B. Kazen, Fatima A. Aboulalazm, and John R. Kirby discuss their recent study, "Reutericyclin mitigates risperidone-induced suppression of anaerobic energy expenditure," published in AJP–Regulatory, Integrative and Comparative Physiology. The authors explore how the gut microbiome, a thermogenic biomass, plays a critical role in regulating energy expenditure. Their study shows that the composition of the microbial community, influenced by both xenobiotics and bacterial metabolites, can impact metabolic function. They found that treatment with reutericyclin counteracts the suppression of anaerobic energy expenditure caused by risperidone. These findings suggest that reutericyclin may offer a new therapeutic approach for managing obesity. Tune in to learn more about the gut microbiome’s role in energy balance and the potential for microbiota-targeted therapies.   Reutericyclin mitigates risperidone-induced suppression of anaerobic energy expenditure Matthew A. Hadiono, Alexis B. Kazen, Fatima A. Aboulalazm, Colin M. L. Burnett, John J. Reho, Tammy L. Kindel, Justin L. Grobe, and John R. Kirby American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2025 328:6, R741-R757

In this episode of The APS Publications Podcast, coauthors John J. Durocher and Ezra Mutai discuss the Editorial Focus titled "Sleep tight with vitamin D’s might" published in AJP–Regulatory, Integrative and Comparative Physiology. The conversation centers on a recent study by Culver et al., which examines the relationship between vitamin D levels and reduced sleep variability. Tune in to hear how these findings shed light on the potential link between vitamin D status and consistent sleep patterns.   Sleep tight with vitamin D’s might John J. Durocher and Ezra Mutai American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2025 328:5, R557-R558

In this episode of The APS Publications Podcast, coauthors Alexander A. Buelow and J. Mikhail Kellawan discuss their recent study, "Inhibition of CYP450 pathways reduces functional sympatholysis in healthy young adults," published in AJP–Regulatory, Integrative and Comparative Physiology. They explore how functional sympatholysis, which has traditionally been considered independent of nitric oxide and prostaglandins, may actually involve endothelial CYP450 pathways. Their findings show that inhibition of CYP450-2C9 reduces sympatholytic responses during dynamic handgrip exercise combined with lower body negative pressure. This suggests that CYP450 plays an important role in regulating blood flow during exercise in healthy individuals. Tune in for insights into vascular physiology, research methodology, and the broader implications of these findings for cardiovascular research.   Inhibition of CYP450 pathways reduces functional sympatholysis in healthy young adults Alexander A. Buelow, Jacob E. Matney, Sarah M. Skillett, John D. Ashley, Jiwon Song, Chris Mixon, Amir Akbari Fakhrabadi, Matthew Stanford, Debra A. Bemben, Daniel J. Larson, and J. Mikhail Kellawan American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2025 328:6, R642-R650

In this podcast, coauthors Emma Elizabeth Sabu Kattuman, Lakshminarayan Reddy Teegala, Somayeh Darzi, Charles K Thodeti, and Sailaja Paruchuri talk about their recently published review, "Leukotrienes: bridging the inflammatory gap in asthma and inflammatory bowel diseases (IBD)." The review highlights how altered leukotriene biosynthesis and signaling contribute to the pathogenesis of both asthma and IBD, and considers the therapeutic implications of targeting leukotriene pathways for patients with concurrent asthma and IBD.   Leukotrienes: Bridging the Inflammatory Gap in Asthma and Inflammatory Bowel Diseases (IBD)Emma Elizabeth Sabu Kattuman, Lakshminarayan Reddy Teegala, Somayeh Darzi, Charles K Thodeti, Sailaja Paruchuri Comprehensive Physiology 2025 15:3, e70022 https://doi.org/10.1002/cph4.70022