Recorded at the 2025 American Heart Association Scientific Sessions, hosts Manesh Patel and Emily O'Brien discuss late-breaking cardiovascular research, including gene-editing therapy for cholesterol, AFib management strategies, and, for coffee lovers, the DECAF trial's findings on caffeine and heart rhythm. #AHA25 #beyondtheendpoint #cardiology #podcast #hearthealth #clinicalresearch

Endocrinologist Jennifer Green discusses how GLP-1 drugs, like Ozempic, evolved from diabetes tools to potential treatments for addiction and heart disease, in this final installment of the obesity series. The discussion also touches on critical questions about long-term use, access, and emerging innovations.

In this second episode of our obesity series, preventive cardiologist Neha Pagidipati sheds light on the discovery, impact, and uses of GLP-1s, like Ozempic and Mounjaro. Learn about the impact these medications are having on diabetes, heart disease, and weight management. 🔗 Access resources related to this episode: https://dcri.org/blog/s2-ep-4-obesity-glp-1s-and-evidence-what-data-tells-us

In the first of a three-part series on obesity and GLP-1 medications, our guest Jennifer Norris shares the evolving landscape of obesity treatment. The conversation addresses common misconceptions and examines how GLP-1 medications, such as Ozempic, have transformed care alongside surgery and lifestyle interventions.

The "Beyond the Headlines" series returns with summer healthcare and research news. Hosts Manesh Patel and Emily O'Brien discuss misconceptions about research funding, a Danish study on vaccine safety, the potential impacts of poor sleep, and how AI tools are transforming medical practice and training. Tags: #medicalnews #healthnews #research #clinicalresearch

Ushering in the second season of Beyond the Endpoint, Lauren Franz, MBChB, MPH, interim director of the Duke Center for Autism and Brain Development, joins Manesh Patel and Emily O'Brien for an in-depth conversation about autism research, care, and community. Franz explains what autism is as a neurodevelopmental spectrum condition and how our understanding of it has evolved significantly over the last decade. The discussion examines the intricate interplay between genetic and environmental factors that may contribute to the development of autism, and explores current intervention approaches. The hosts and guest also discuss the groundbreaking research at Duke University that employs artificial intelligence to analyze medical records for earlier detection of autism. This approach could help shorten the time between when autism can be diagnosed and when it is typically identified. Throughout the episode, Franz stresses the importance of involving the autism community in research and decision-making processes.

What do championship sports teams and successful research institutions have in common? In the season finale of Beyond the Endpoint, Dr. Adrian Hernandez joins hosts Manesh Patel and Emily O’Brien to break down what clinical research institutions can learn from their counterparts on the court. From basketball dynasties to resilient mindsets, Dr. Hernandez offers a powerful playbook on building strong research systems, prioritizing patients, and why sharing “negative” results matters. Don’t miss the wrap-up to Season 1! 🔗 Access resources related to this episode https://dcri.org/blog/ep-10-playing-advance-care-championship-mindset-clinical-research

In this new episode of the Beyond the Endpoint series, “Beyond the Headlines,” hosts Emily O’Brien and Manesh Patel break down what’s you should know about these trending medical topics. From hype to headlines—get clinical insight that goes deeper. Access resources related to this episode https://dcri.org/blog/ep-9-beyond-headlines 187880

Why do people volunteer for clinical trials — and what should they know before doing so? In this episode of Beyond The Endpoint, we explore common questions, reasons, and myths about clinical trial participation. Hosts Manesh Patel and Emily O’Brien talk with guest Krista Camuglia, a Research Practice Manager with the Duke Heart Center Clinical Research Unit, who brings unique insights thanks to her work on the frontlines of research coordination. 🎙️ Listen to "Part 1: Why Participate in Clinical Research?" https://dcri.org/blog/ep-7-stepping-why-participate-clinical-research

In this episode, cancer survivor Katie Ortman-Doble opens up about her journey through clinical research and why she chose to participate. Hosts Emily O’Brien and Manesh Patel, joined by Jenny Cook, talk about the life-saving potential of clinical trials and the real impact they have on patients and science. Hear Katie’s inspiring story and the reasons behind her decision to join a trial. 🔗 Access resources related to this episode https://dcri.org/blog/ep-7-stepping-why-participate-clinical-research

In this episode of Beyond the Endpoint, former FDA commissioner Dr. Robert Califf joins hosts Manesh Patel and Emily O’Brien to discuss critical challenges shaping the future of patient care. From misinformation to regulatory science to the financialization of healthcare, Dr. Califf has unique insight into the evolving healthcare landscape and the role of data in improving patient outcomes. 🔗 Access resources related to this episode https://dcri.org/blog/ep-6-bridging-science-and-policy-conversation-dr-robert-califf

Ozempic curbing alcohol cravings, ADHD linked to shorter life expectancy, and an NBA rising star diagnosed with DVT—what does the science actually say? In this first episode of Beyond the Headlines, a new Beyond the Endpoint series, hosts Emily O’Brien and Manesh Patel break down the research behind these trending stories. Access resources related to this episode https://dcri.org/blog/ep-5-beyond-headlines

Smartwatches, fitness trackers, and health data—how are wearables reshaping clinical research? In this episode, Dr. Marat Fudim joins us for an insightful discussion on how wearable technology is shaping the way we monitor health and conduct research. Topics include: • Are wearables improving patient care or just tracking steps? • How do researchers use wearable data in clinical trials? •What are the biggest challenges in integrating this tech? 🎙️ Listen now and explore the possibilities of wearable health tech! 🔗 Access resources related to this episode https://dcri.org/blog/ep-4-wearables-clinical-research-data-trends-and-challenges

In this episode of Beyond the Endpoint, Emily O’Brien and Manesh Patel sit down with Leslie Curtis, former senior FDA policy advisor, to explore the FDA’s role in balancing science, public health, and regulation, along with how political transitions influence clinical research, healthcare funding, and the approval process for new treatments. 🔗 Access resources related to this episode https://dcri.org/blog/ep-3-intersection-politics-and-medicine-impacts-clinical-practice

Reducing hypertension risk isn’t just about cutting salt. This week on Beyond The Endpoint, Emily O’Brien, Manesh Patel, and Jenny Cook talk with Dr. Dhruv Kazi about the complex public health battle against hypertension. From interventions to strategies for patient and physician adherence, this episode covers scalable solutions to change the future of hypertension. 🔗 Access resources related to this episode https://dcri.org/blog/ep-2-bending-curve-rewriting-future-hypertension

In this episode of "Beyond the Endpoint," hosts Emily O'Brien and Manesh Patel are joined by guest host Jenny Cook to discuss grief among healthcare providers with Tony Galanos, a researcher and physician at the Duke University School of Medicine. Galanos — "Dr. G" as he's called around Duke — shares insights from his 12-year program helping other clinicians to address and process the grief that can be an inevitable part of their work. He highlights the emotional toll that healthcare work can take and the importance of acknowledging and processing grief. The episode explores the concept of the "hidden curriculum" in medical training, the practice of "the pause" after intense resuscitation efforts, and also dives into how everyone can better manage their own grief after losing a loved one. 🔗 Access resources related to this episode https://dcri.org/blog/ep-1-caring-through-loss-role-grief-clinical-settings

Inviting Our Colleagues To Participate In DCRI On Record by Duke Clinical Research Institute

John Shepherd And Michele Nolen by Duke Clinical Research Institute

Assessing Results of Open-label, Comparative Effectiveness Trials for Cardio-metabolic Drugs by Duke Clinical Research Institute

Duke IBD Podcast Series: IBD and Nutrition by Duke Clinical Research Institute