In this episode, Prof. Deepak Saini welcomes Prof. David Furman to discuss the intricate relationship between the immune system, inflammation, and the biology of aging. The conversation highlights the development of a new aging clock based on immune biomarkers, offering insights into multimorbidity and how environmental and genetic factors together shape the aging process. Special attention is given toexternal environmental stressors—including pollutants, toxins, plastics, andcosmetics—that can penetrate biological barriers and accelerate cellular decline, underscoring the importance of public awareness and policymaking in mitigating these risks.The discussion then turns to innovative diagnostic approaches, with a focus on quantum electro spectroscopy as a promising tool for identifying immune system biomarkers and advancing personalized medicine.Prof. Furman also explores unique research models, such as space flight and microgravity experiments, to better understand cellular aging mechanisms and compare them with other experimentalmodels.Finally, lifestyle considerations are examined, with emphasis on how lessons from hunter-gatherer living—marked by activity and natural resilience—may protect against inflammation and chronic disease far more effectively than sedentary modern lifestyles.Time stamps:00:00 – Introduction01:27 – Introduction to Dr. David Furman02:00 – Relationship between the Immune system, Inflammation and Aging07:05 – Environmental factors, immune profiles & baseline values10:20 – AI, tech, and aging research16:23 – Aging in microgravity24:02 – Inflammation and aging29:15 – Exposomal factors contributing to inflammation35:40 – Diversity in microbiome38:57 – Dr. Furman’s personal practices for longevity43:00 – Wearables and trajectories of health47:16 – Aging clocks48:57 – SupplementsAbout Guest: David Furman, PhD, is an Associate Professor and Director of the AI and Bioinformatics Platform at the Buck Institute for Research on Aging, where his work centers on using advanced technologies to gain insight into how people age and how aging can be improved. He is renowned for his interdisciplinary approach, integrating big data, artificial intelligence, and machine learning to analyze the immune system and uncover its role in aging and related diseases. Dr. Furman’sresearch has led to developments such as an inflammatory-aging clock andcollaborations across diverse fields, all aimed at understanding how life experiences and exposures (the “exposome”) impact the immune system and influence the rate of aging.Connect with Dr. David Furman:Furman lab: https://www.buckinstitute.org/lab/furman-lab/Edifice health: https://edificehealth.com/team/david-furman-phdAbout Biopeak: Biopeak is a deep science-led longevity organization focused on personalized, precise, predictive, and preventive healthcare. Built for South Asia, our approach blends cutting-edge diagnostics with systems science to craft personalised health plans. Biopeak helps you not just live longer—but live without limits. Biopeak. Decode your path to Limitless Living.Follow Us: Longevity India: https://www.longevity.iisc.ac.in/Biopeak: https://www.biopeak.com/LinkedIn: https://www.linkedin.com/company/longevity-india-iisc/Instagram: https://www.instagram.com/longevity_iisc/Spotify: https://open.spotify.com/show/0NXTdG0fBIfmKIHV2vkxbVDisclaimers: The content shared on the Biopeak Live podcast is intended for general educational purposes only and should not be considered as medical advice. We strongly recommend consulting a licensed healthcare professional for any health-related concerns, especially before making any lifestyle, dietary, or medical changes based on the content provided in this podcast.
In this episode, we’re joined by Dr. Satchidananda Panda, Professor at the Regulatory Biology Laboratory, Salk Institute, California, to dive into the fascinating science of the circadian rhythm and its powerful impact on our health.
We explore the importance of circadian rhythm for the body’s daily functioning and how it works, along with the health risks that come from disrupting it, something common among shift workers, students, and new mothers. Dr. Panda also explains how hormones, light, and food influence our internal clock, and shares practical tips to reset and restore balance when our rhythm gets off track. He emphasizes why aligning with the circadian rhythm is key for lifestyle changes, better health, and long-term longevity.
When your circadian rhythm is in sync, it boosts overall health, but when disrupted, it can raise the risk of chronic disease and poor health.
Time stamp:
00:00- Introduction
01:41- Introduction to Dr. Satchin Panda
06:09- Fundamental functions of circadian clock
08:45- Circadian Clock gene
11:59- Hormonal regulation of circadian clock
14:55- Technology to measure circadian clock
19:01- Shift worker
26:35- Time restricted eating
31:07- Sleep and food timing
38.35- Effect on pathologies and life incidence
40:58- Night Owl
45:34- Entrepreneurship in the circadian rhythm space
50:24- Rapid fire questions
#health, #longevity, #biologicalclock, #circadianrhythm, #stress, #sleep, #metabolism, #aging
The Guest : Dr. Satchidananda (Satchin) Panda, is a Professor at the Salk Institute in California, where he conducts groundbreaking research on circadian rhythms and their impact on behaviour, physiology, and metabolism. He has been recognized with prestigious awards, including the Julie Martin Mid-Career Award in Aging Research and the Dana Foundation Award in Brain and Immune System Imaging. Discovered blue-light sensing cells in the retina which influence our circadian clock and related behaviours. His work has highlighted time-restricted feeding and its potential in preventing and reversing metabolic diseases.
Connect with Dr. Satchidananda Panda:
Panda Lab: https://panda.salk.edu
Ontime Health: https://getontimehealth.com
Know more:
The Circadian Code: https://www.penguinrandomhouse.com/books/592260/the-circadian-code-by-satchin-panda-phd/
About Biopeak : Biopeak is a deep science-led longevity organization focused on personalized, precise, predictive, and preventive healthcare. Built for South Asia, our approach blends cutting-edge diagnostics with systems science to craft personalised health plans. Biopeak helps you not just live longer—but live without limits.
Biopeak. Decode your path to Limitless Living.
Follow Us:
Longevity India: https://www.longevity.iisc.ac.in/podcast
Biopeak: https://www.biopeak.com/
LinkedIn: / longevity-india-iisc
Instagram: / longevity_iisc
Disclaimers: The content shared on the Biopeak Live podcast is intended for general educational purposes only and should not be considered as medical advice. We strongly recommend consulting a licensed healthcare professional for any health-related concerns, especially before making any lifestyle, dietary, or medical changes based on the content provided in this podcast.
In continuation of our conversation from previous episode with Dr. Sue Anne Toh, Co-Founder and Director of NOVI, we dive deeper into what happens when the drivers of metabolism go off track - leading to metabolic dysfunction. We explore how factors like body composition, insulin resistance, and chronic inflammation contribute to metabolic syndrome, particularly in South Asian populations. Dr. Toh shares insights on how wearable devices can empower individuals to understand their physiology and make meaningful behaviour changes.We also cover practical ways to improve gut health and rapid-fire round tackling common metabolism myths and facts.Time stamps:01:40 - Introduction Sue Anne 03:36 - Drivers of metabolism and metabolic syndrome 06:32 - Indicators of metabolic distress 10:53 - HbA1c marker16:14 - Inflammation on metabolism 24:38 - Inflammation marker threshold27:05 - Skinny fat cannot be eyeball, how to triage – Asian population 31:07 - Metabolic markers-Indian 32:24 - Supplements to delay metabolic distress onset 35:58 - Local nutraceuticals36:57 - Sequencing order of food40:58 - Time restricted eating44:30 - Wearables in managing health 55:04 - Negative gamification of wearable device57:02 - Convergence of health monitoring devices and AI58:47- Metabolic age01:00:00 - Exercise01:05:05 - Supplements for better gut health01:08:22 - Rapid fire- practical questions 01:16:46 - ClosingThe Guest: Dr. Sue Anne Toh is the Co-Founder, CEO and Medical Director of NOVI. She is also Adjunct Associate Professor, Yong Loo Lin School of Medicine, National University of Singapore. Dr. Toh is a specialist in internal medicine, diabetes, endocrinology, and metabolism, with expertise in health systems, value-based healthcare, evidence-based wellness, integrated health services development, delivery, and evaluation.Connect with Dr. Sue Anne Toh: https://novi-health.com/ ,https://www.linkedin.com/in/sue-anne-toh-4225897/ References:1.https://clinicaltrials.gov/study/NCT02838693?term=NCT02838693&rank=12.Magkos F, Lee MH, Lim M, Cook AR, Chhay V, Loh TP, Chia KS, Baig S, Ang IYH, Tay JYY, Khoo CM, Halter JB, Toh SA. Dynamic assessment of insulin secretion and insulin resistance in Asians with prediabetes. Metabolism. 2022 Mar;128:154957. doi: 10.1016/j.metabol.2021.154957. Epub 2021 Dec 21. PMID: 34942192.3.Lee MH, Febriana E, Lim M, Baig S, Halter JB, Magkos F, Toh SA. Asian females without diabetes are protected from obesity-related dysregulation of glucose metabolism compared with males. Obesity (Silver Spring). 2023 Sep;31(9):2304-2314. doi: 10.1002/oby.23833. Epub 2023 Aug 3. PMID: 37534562.4.Lee MH, Febriana E, Lim M, Baig S, Shen L, Dalakoti M, Chew N, Loh TP, Chan M, Chia KS, Kong AP, Cook AR, Halter JB, Magkos F, Toh SA. Performance of the 1 h oral glucose tolerance test in predicting type 2 diabetes and association with impaired β-cell function in Asians: a national prospective cohort study. Lancet Reg Health West Pac. 2024 Dec 31;54:101278. doi: 10.1016/j.lanwpc.2024.101278. PMID: 39840148; PMCID: PMC11750441.About Biopeak: Biopeak is a deep science-led longevity organization focused on personalized, precise, predictive, and preventive healthcare. Built for South Asia, our approach blends cutting-edge diagnostics with systems science to craft personalised health plans. Biopeak helps you not just live longer—but live without limits. Biopeak. Decode your path to Limitless Living.Follow Us: Longevity India: https://www.longevity.iisc.ac.in/Biopeak: https://www.biopeak.com/LinkedIn: https://www.linkedin.com/company/longevity-india-iisc/Instagram: https://www.instagram.com/longevity_iisc/Spotify: https://open.spotify.com/show/0NXTdG0fBIfmKIHV2vkxbV
In this episode, we’re joined by Dr. Sue Anne Toh, Co-Founder and Director of NOVI, for an insightful discussion on metabolism. We explore key aspects of metabolism, including the roles of organs, hormones, metabolic rate, and metabolic health. Dr. Toh also highlights the distinct metabolic traits seen in Indian and broader Asian populations, emphasizing the importance of studying and understanding our own population for more effective health strategies.Time stamp:00:00 - Introduction01:39 - Introduction Sue Anne Toh 04:44 - Mitochondria – hub of metabolism 09:16 - Is mitochondria making us age ? Function of mitochondria 13:05 - Different fuel different effect- depend on the whole being 16:25 - Regulatory mechanisms and organs involved in metabolic control20:30 - Signs of metabolic dysfunction 24:47 - Metabolic rate 35:07 - BMI of south Asian Population 37:26 - Skinny fat38:31 - South-east Asians need to work harder to keep metabolically fit45:00 - Summary and closingThe Guest: Dr. Sue Anne Toh is the Co-Founder, CEO and Medical Director of NOVI. She is also Adjunct Associate Professor, Yong Loo Lin School of Medicine, National University of Singapore. Dr. Toh is a specialist in internal medicine, diabetes, endocrinology, and metabolism, with expertise in health systems, value-based healthcare, evidence-based wellness, integrated health services development, delivery, and evaluation.Connect with Dr. Sue Anne Toh: https://www.linkedin.com/in/sue-anne-toh-4225897/References: 1.Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009 Apr 9;360(15):1509-17. doi: 10.1056/NEJMoa0810780. PMID: 19357406; PMCID: PMC2859951.2.Parvaresh Rizi E, Baig S, Shabeer M, Teo Y, Mok SF, Loh TP, Magkos F, Virtue S, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity. Nutr J. 2016 Dec 1;15(1):100. doi: 10.1186/s12937-016-0219-0. PMID: 27903298; PMCID: PMC5131405.3.Baig S, Parvaresh Rizi E, Shabeer M, Chhay V, Mok SF, Loh TP, Magkos F, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Metabolic gene expression profile in circulating mononuclear cells reflects obesity-associated metabolic inflexibility. Nutr Metab (Lond). 2016 Oct 27;13:74. doi: 10.1186/s12986-016-0135-5. PMID: 27800008; PMCID: PMC5081666.Parvaresh Rizi E, Loh TP, Baig S, Chhay V, Huang S, Caleb Quek J, Tai ES, Toh SA, Khoo CM. A high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, PYY and GLP-1 responses in Chinese men. PLoS One. 2018 Jan 31;13(1):e0191609. doi: 10.1371/journal.pone.0191609. PMID: 29385178; PMCID: PMC5792004.About Biopeak:Biopeak is a deep science-led longevity organization focused on personalized, precise, predictive, and preventive healthcare. Built for South Asia, our approach blends cutting-edge diagnostics with systems science to craft personalised health plans. Biopeak helps you not just live longer, but live without limits.Biopeak. Decode your path to Limitless Living.Follow Us:Longevity India
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Apple podcastDisclaimers:The content shared on the Biopeak Live podcast is intended for general educational purposes only and should not be considered as medical advice. We strongly recommend consulting a licensed healthcare professional for any health-related concerns, especially before making any lifestyle, dietary, or medical changes based on the content provided in this podcast.
Know about the topic:
In this episode, our host, Mr. Prashanth Prakash, co-host Prof. Deepak Saini (IISc), and guest Mr. Rajesh Reddy, founder and investor at Project Serotonin explore how technology is reshaping the health system—from the rise of digital health platforms to the emergence of longevity clinics and AI-driven, data-centric models of care. The conversation unpack the evolution of digital platforms through three generations and examine how these shifts are enabling precision screening, real-time health measurement, and the proactive management of health outcomes.
The discussion also delve into Longevity India’s pioneering approach to studying population-specific agingtrends, leveraging phenotypic sensing and system biology. The episode discusses how advancements in technology are transforming healthcare delivery—pushing the paradigm toward preventative care and lifestyle optimization.
Time stamp
00.00-Introduction
02.03- Intro Rajesh Reddy
02.30- Medicine 2.0 vs Medicine 3.0
08.14- Systems biology to precision Medicine
15.05- Dynamic biological system to influencing personal decision
18.28- Close loop learning model
21.03- Leap frog longevity
25.20- Traditional health system to integrative multimodal clinics
28.48- Start up driving innovation in Longevity
30.28- Summary and Closing
Mr. Rajesh Reddy is aserial entrepreneur and cross-disciplinary innovator. He is the founder andinvestor at Project Serotonin- a precision medicine platform. Over the years,Rajesh has led companies that pioneered industry-first innovations acrosssectors. He was recognized by MIT Technology Review's TR35 list as one of thetop 35 global technology innovators under the age of 35 in 2002 and holdsmultiple patents across diverse fields. His most recent venture, JulySystems—acquired by Cisco and now known as Cisco Spaces—has grown into theworld’s largest smart buildings and indoor location cloud platform. Afterdecades of building multi-million dollar enterprises, Rajesh has come fullcircle, returning to his deeply personal mission: Project Serotonin.
Connect with Mr. RajeshReddy
Presented by Longevity India |Supported by Biopeak
Subscribe now and stay tuned. Episodes coming soon !
#BiopeakLive #LongevityIndia#HealthyAging #Health #SciencePodcast #precisionmedicine #HealthTech#DigitalHealth #PreventativeCare
About Biopeak:
Biopeak is a deep science-led longevity organization focusedon personalized, precise, predictive, and preventive healthcare. Built for South Asia, our approach blends cutting-edge diagnostics with systems science to craft personalised health plans. Biopeak helps you not just live longer—but live without limits.
Biopeak.
Decode your path to Limitless Living.
Follow Us
Disclaimers:The content shared on the BiopeakLive podcast is intended for general educational purposes onlyand should notbe considered as medical advice. We strongly recommend consulting a licensed healthcare professionalfor any health-related concerns, especially before making any lifestyle,dietary, or medical changes based on the content provided in this podcast.
Know about the topic:
In this episode, our host Mr. Prashanth Prakash, co-host Prof. Deepak Saini (IISc), and guest Mr. Rajesh Reddy, founder and investor at ProjectSerotonin, delve into the role of genome–phenome interactions in shaping health and longevity.
Key topics discussed include longevity interventions, genetic predispositions and nutrient deficiencies unique to Indian populations, their long-term health implications, individualised treatment approaches, integrating Ayurvedawith modern science for better health outcomes.
Stay tuned for Part 3, where the conversation expands beyond genome–phenome insights into the future of technology and precision medicine.
Time Stamps:
00:00 - Introduction
01:12 - Introduction Rajesh Reddy
01:40 - Central Dogma of Longevity
04:54 - Genome-Phenome interaction
09:18 - Genetic Predispositions in India
11:17 - Metabolism -South Asian
16:55 - Supplements and Nutrition
20:12 - Benefits of Supplements
27:10 - Longevity India's Mission
30:30 - Longevity Therapies
39.39 - Exercise/Yoga
42:56 - Integration of Ayurvedic Practices and Modern Pharmacology
47:35 - Closing
Mr. Rajesh Reddy is a serial entrepreneur and cross-disciplinary innovator. He is the founder and investor at Project Serotonin- a precision medicine platform. Over the years, Rajesh has led companies that pioneered industry-first innovations across sectors. He was recognized by MIT Technology Review's TR35 list as one of the top 35 global technology innovators under the age of 35 in 2002 and holds multiple patents across diverse fields. His most recent venture, July Systems—acquired by Cisco and now known as Cisco Spaces—has grown into the world’s largest smart buildings and indoor location cloud platform. After decades of building multi-million dollar enterprises, Rajesh has come full circle, returning to his deeply personal mission: Project Serotonin.
Connect with Mr. RajeshReddy
Presented by Longevity India |Supported by Biopeak
Subscribe now and stay tuned. Episodes coming soon !
#BiopeakLive #LongevityIndia#HealthyAging #Healthspan #SciencePodcast #IndiaHealth #precisionmedicine
About Biopeak:
Biopeak is a deep science-led longevity organization focusedon personalized, precise, predictive, and preventive healthcare. Built forSouth Asia, our approach blends cutting-edge diagnostics with systems scienceto craft personalised health plans. Biopeak helps you not just live longer—butlive without limits.
Biopeak. Decode your path to Limitless Living.
Follow Us
Disclaimers:The content shared on the Biopeak Live podcast is intended for general educational purposes only and should not be considered as medical advice. We strongly recommend consulting a licensed healthcare professional for anyhealth-related concerns, especially before making any lifestyle, dietary, or medical changes based on the content provided in this podcast.
Know about the topic:
Artificial intelligence and precision medicine are at the core of shaping our vision of healthy longevity. In this second episode, host Mr. Prashanth Prakash, co-host Prof. Deepak Saini, and special guest Mr. Rajesh Reddy- a tech entrepreneur discusses the evolving perceptions of healthy aging in India and in a global context through the lenses of culture, spirituality, and vanity.
Stay tuned for part 2 and 3, where the conversation moves beyond aging perceptions and deep dives into intersections of technology, genome, phenome, society and longevity.
Time Stamps:
00:00 – Introduction01:31 - Intro Rajesh Reddy02:05 - Blue Zones03:41 - Aging studies in India04:37 - Global perception in aging08:15 - Aging perception in India11:44 - Negative impact of economic growth15:23 - Health, nutrition and physical appearance21:13 - Closing
About Guest:
Mr. Rajesh Reddy is a serial entrepreneur and cross-disciplinary innovator. He is the founder and investor at Project Serotonin- a precision medicine platform. Over the years, Rajesh has led companies that pioneered industry-first innovations across sectors. He was recognized by MIT Technology Review's TR35 list as one of the top 35 global technology innovators under the age of 35 in 2002 and holds multiple patents across diverse fields. His most recent venture, July Systems—acquired by Cisco and now known as Cisco Spaces—has grown into the world’s largest smart buildings and indoor location cloud platform. After decades of building multi-million dollar enterprises, Rajesh has come full circle, returning to his deeply personal mission: Project Serotonin.
Connect with Mr. Rajesh Reddy
Presented by Longevity India | Supported by Biopeak
Subscribe now and stay tuned. Episodes comingsoon !
#BiopeakLive #LongevityIndia #HealthyAging #Healthspan #SciencePodcast#IndiaHealth #precisionmedicine
About Biopeak:
Biopeak is a deep science-led longevity organization focused on personalized, precise, predictive, and preventive healthcare. Built for South Asia, our approach blends cutting-edge diagnostics with systems science to craft personalised health plans. Biopeak helps you not just live longer—but live without limits.
Biopeak. Decode your path toLimitless Living.
Follow Us
Disclaimers:The content shared on the Biopeak Live podcast is intended for general educational purposes only and should not be considered as medical advice. We strongly recommend consulting a licensed healthcare professional for any health-related concerns, especially before making any lifestyle, dietary, or medical changes based on the content provided in this podcast.
Can we slow down aging to live longer, healthier lives? In Episode #1 of Biopeak Live, our host, Mr. Prashanth Prakash, and co-host, Dr. Deepak Saini, sit down with Dr. Venki Ramakrishnan to explore the age-old question of why humans age, breakthroughs in aging interventions, and key areas of focus to address the challenges of aging.
Time Stamps:
01.08- Introduction to Venki Ramakrishnan
05.00- Aging is Universal
13.30- Biological Age
20.44- Lifestyle as Medicine
24.46- Therapeutics
34.45- Longevity Start up
35.45- Democratic shift and economic inequality
39.11- Closing: the Hype and Hope
The Guest: Dr. Ramakrishnan leads alab at the MRC Laboratory of Molecular Biology in Cambridge, England and wasawarded the Nobel Prize in Chemistry in 2009 for his groundbreaking research onthe structure and function of the ribosome, which has significantly deepenedour understanding of protein synthesis and its role in life. Dr. Ramakrishnancurrently is a member of the National Academy ofSciences and is also a formerPresident of the Royal Society- 2015 to 2020. He is the author of the books“Gene Machine” and “Why We Die”.
Connect with Dr Venki Ramakrishnan: https://www2.mrc-lmb.cam.ac.uk/group-...
Read about the discussion:
Why We Die book: https://www.harpercollins.com/products/why-we-die-venki-ramakrishnan?variant=42608461807650
The Dance of Life: https://www.penguin.co.uk/books/438509/the-dance-of-life-by-magdalena-zernicka-goetz/9780753552957
The Secret Body: https://press.princeton.edu/books/hardcover/9780691210582/the-secret-body
Extra Life: https://www.penguinrandomhouse.com/books/594501/extra-life-by-steven-johnson/
Life's Greatest Secret: https://profilebooks.com/work/lifes-greatest-secret/
The Youth Pill: https://www.penguinrandomhouse.com/books/304811/the-youth-pill-by-david-
Know more:
Why We Die: The New Science of Ageing and the Quest for Immortality by Venki Ramakrishnan.
World population Aging
https://www.un.org/en/development/desa/population/publications/pdf/ageing/WPA2017_Highlights.pdf
India aging population estimate
https://india.unfpa.org/en/news/indias-ageing-population-why-it-matters-more-ever
Presented by Longevity India | Supported by Biopeak
Subscribe now and stay tune! Episodes coming soon !
#BiopeakLive#LongevityIndia #HealthyAging #VenkiRamakrishnan #Healthspan #SciencePodcast#LongevityScience #IndiaHealth
About Biopeak: (shorter version fromShristi)
Biopeak is a deep science-led longevity organization focused on personalized, precise, predictive, and preventive healthcare. Built for South Asia, our approach blends cutting-edge diagnostics with systems science to craft personalised health plans. Biopeak helps you not just live longer—but live without limits.
Biopeak.Decode your path to Limitless Living.
Follow Us:
Disclaimers: The content shared on the Biopeak Live podcast is intended for general educational purposes only and should not be considered as medical advice. We strongly recommend consulting a licensed healthcare professional for any health-related concerns, especially before making any lifestyle, dietary, or medical changes based on the content provided in this podcast.