Welcome to Cardiology Today – Recorded November 15, 2025. This episode summarizes 5 key cardiology studies on topics like ventricular systolic function and congenital heart disease. Key takeaway: Albuminuria and Acute Heart Failure Risk. Article Links: Article 1: Transcriptomic and proteomic profiling shows dysregulated immune and metabolic pathways in arrhythmogenic cardiomyopathy. (ESC heart failure) Article 2: Albuminuria is associated with worse outcomes in non-diabetics hospitalized with acute heart failure. (ESC heart failure) Article 3: Prognostic Determinants in Patients with Secondary Tricuspid Regurgitation Classified by Right Ventricular Systolic Function. (Cardiology) Article 4: Activation of endothelial TRPV4 exacerbates myocardial ischemia-reperfusion injury via vascular integrity impairment. (The Canadian journal of cardiology) Article 5: Echocardiographic Indices of Ventricular Systolic Function in Adults with Fontan Palliation: Feasibility, Reproducibility, and Prognostic Implications. (The Canadian journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/albuminuria-and-acute-heart-failure-risk-11-15-25/ Featured Articles Article 1: Transcriptomic and proteomic profiling shows dysregulated immune and metabolic pathways in arrhythmogenic cardiomyopathy. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41229088 Summary: Complete results were not available in the abstract. This study aimed to characterize the myocardial transcriptome and proteome in patients with arrhythmogenic cardiomyopathy. Specific numerical findings on which immune and metabolic pathways were dysregulated, or the detectability of key molecules in plasma and tissue, were not provided. Article 2: Albuminuria is associated with worse outcomes in non-diabetics hospitalized with acute heart failure. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41224248 Summary: Complete results were not available in the abstract. This study evaluated if albuminuria was associated with adverse outcomes in non-diabetic individuals hospitalized with acute heart failure. Specific numerical findings regarding the association between albuminuria and patient outcomes were not provided. Article 3: Prognostic Determinants in Patients with Secondary Tricuspid Regurgitation Classified by Right Ventricular Systolic Function. Journal: Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41231743 Summary: Complete results were not available in the abstract. This retrospective study aimed to stratify patients with severe secondary tricuspid regurgitation based on right ventricular fractional area change. Specific echocardiographic parameters influencing prognosis or definitive conclusions on patient stratification were not provided. Article 4: Activation of endothelial TRPV4 exacerbates myocardial ischemia-reperfusion injury via vascular integrity impairment. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41238115 Summary: Complete results were not available in the abstract. This study hypothesized that endothelial transient receptor potential vanilloid 4 contributes to post-ischemic vascular hyperpermeability and myocardial injury. Specific numerical findings demonstrating the exacerbation of ischemia-reperfusion injury or the impairment of vascular integrity were not provided. Article 5: Echocardiographic Indices of Ventricular Systolic Function in Adults with Fontan Palliation: Feasibility, Reproducibility, and Prognostic Implications. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41238114 Summary: Complete results were not available in the abstract. This retrospective cohort study assessed the feasibility and reproducibility of echocardiogram-derived systolic function indices in adults with Fontan palliation. Specific numerical findings on the relationship between these indices and clinical outcomes were not p