Welcome to Cardiology Today – Recorded January 04, 2026. This episode summarizes 5 key cardiology studies on topics like quantitative flow ratio and sinus rhythm. Key takeaway: Thromboaspiration Not Routine in STEMI. Article Links: Article 1: Selective Use of Thromboaspiration in STEMI: CMR Evidence Against Routine Practice. (The American journal of cardiology) Article 2: Transcatheter Aortic Valve Replacement for Mixed Aortic Valve Disease Versus Predominant Aortic Stenosis. (The American journal of cardiology) Article 3: Comparison of Functional Tricuspid Regurgitation Following Transcatheter Atrial Septal Defect Closure in Adult Patients With Sinus Rhythm, Post-ablation Sinus Rhythm, and Permanent Atrial Fibrillation. (The American journal of cardiology) Article 4: Persistent Racial Disparities in Chronic Limb-Threatening Ischemia Outcomes and Utilization Among US Medicare Patients. (The American journal of cardiology) Article 5: Unmasking Myocardial Bridge-Related Ischemia by Quantitative Flow Ratio Functional Evaluation. (The American journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/thromboaspiration-not-routine-in-stemi-01-04-26/ Featured Articles Article 1: Selective Use of Thromboaspiration in STEMI: CMR Evidence Against Routine Practice. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41483841 Summary: This study provided cardiac magnetic resonance imaging evidence against the routine use of thromboaspiration as an adjunct to primary percutaneous coronary intervention in ST-elevation myocardial infarction. The data demonstrated concerns about thromboaspiration’s potential to aggravate microvascular injury. The study confirmed that the effect of thromboaspiration on microvascular perfusion remains uncertain, leading to the conclusion that routine application is not supported. Article 2: Transcatheter Aortic Valve Replacement for Mixed Aortic Valve Disease Versus Predominant Aortic Stenosis. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41138981 Summary: This meta-analysis compared the survival of patients with mixed aortic valve disease versus predominant aortic stenosis following transcatheter aortic valve replacement. The study found that patients with mixed aortic valve disease demonstrated distinct survival outcomes compared to those with predominant aortic stenosis. This research provides crucial insights into differential survival rates for specific aortic valve pathologies undergoing transcatheter aortic valve replacement (TAVR). Article 3: Comparison of Functional Tricuspid Regurgitation Following Transcatheter Atrial Septal Defect Closure in Adult Patients With Sinus Rhythm, Post-ablation Sinus Rhythm, and Permanent Atrial Fibrillation. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41061875 Summary: This study compared the sequential changes in functional tricuspid regurgitation following transcatheter atrial septal defect closure across different preprocedural cardiac rhythms. The research categorized patients into groups with sinus rhythm, sinus rhythm after catheter ablation for atrial fibrillation, and permanent atrial fibrillation. The data demonstrated differential changes in tricuspid regurgitation based on the patient’s baseline and post-ablation cardiac rhythm status after atrial septal defect closure. Article 4: Persistent Racial Disparities in Chronic Limb-Threatening Ischemia Outcomes and Utilization Among US Medicare Patients. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41052695 Summary: This study demonstrated persistent racial disparities in chronic limb-threatening ischemia outcomes and healthcare utilization among U.S. Medicare patients. The data showed that Black patients continued to experience higher amputation rates and reduced access to vascular care compared to White bene

Welcome to Cardiology Today – Recorded January 04, 2026. This episode summarizes 5 key cardiology studies on topics like dendritic cells and allograft tolerance. Key takeaway: Epicardial Cells Regulate Ventricular Compaction. Article Links: Article 1: Activation of the Immunoregulatory Cation Channel TMEM176B by a Nitroalkene Derivative of Salicylate Prolongs Graft Survival. (Transplantation) Article 2: Invasion of Epicardial-Derived Cells to the Trabeculae Mediated by NFPs-Fgf Signaling Regulates Ventricular Compaction. (Circulation. Heart failure) Article 3: Outcomes of Percutaneous Coronary Intervention for Cardiogenic Shock After Coronary Artery Bypass Graft. (The American journal of cardiology) Article 4: Impacts of Mitral Annular Calcification on Heart Failure With Preserved Ejection Fraction. (The American journal of cardiology) Article 5: Mini-Crush Versus Double Kissing Crush in Bifurcation Percutaneous Coronary Intervention: Insights From PROGRESS-BIFURCATION Registry. (The American journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/epicardial-cells-regulate-ventricular-compaction-01-04-26/ Featured Articles Article 1: Activation of the Immunoregulatory Cation Channel TMEM176B by a Nitroalkene Derivative of Salicylate Prolongs Graft Survival. Journal: Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40691833 Summary: Researchers found that transmembrane protein 176B, an intracellular cation channel, is associated with allograft tolerance. The study demonstrated that this protein controls the tolerogenic function of dendritic cells and inhibits the NOD-, LRR-, and pyrin domain-containing protein 3 inflammasome. Activation of transmembrane protein 176B by a nitroalkene derivative of salicylate successfully prolonged graft survival. These findings reveal a mechanism by which transmembrane protein 176B activation contributes to sustained graft survival. Article 2: Invasion of Epicardial-Derived Cells to the Trabeculae Mediated by NFPs-Fgf Signaling Regulates Ventricular Compaction. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41477684 Summary: Researchers found that the invasion of epicardial-derived cells into the trabeculae regulates ventricular compaction. This crucial process is mediated by Numb and fibroblast growth factor signaling pathways. These findings establish a fundamental mechanism underlying normal ventricular compaction and provide significant insight into the pathogenesis of left ventricular noncompaction cardiomyopathy. Understanding this pathway offers a clearer picture of this prevalent pediatric cardiomyopathy. Article 3: Outcomes of Percutaneous Coronary Intervention for Cardiogenic Shock After Coronary Artery Bypass Graft. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41161558 Summary: This retrospective cohort study conducted a comparative analysis of outcomes for adults experiencing myocardial infarction and cardiogenic shock following coronary artery bypass graft surgery. The study directly compared patients who underwent percutaneous coronary intervention within 24 hours to those who did not. Researchers utilized propensity score matching and Fine-Gray models to derive adjusted and unadjusted hazard ratios and subdistribution hazard ratios for various outcomes. This comprehensive approach established a direct comparison of interventional strategies in this specific, high-risk patient population. Article 4: Impacts of Mitral Annular Calcification on Heart Failure With Preserved Ejection Fraction. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41138985 Summary: A multi-cohort study successfully created and propensity score matched various cohorts to investigate the links between mitral annular calcification and heart failure with preserved ejection fraction. Researchers found that hospitalized patients without prior heart failure, w

Welcome to Cardiology Today – Recorded December 07, 2025. This episode summarizes 5 key cardiology studies on topics like Aficamten and left ventricular dysfunction. Key takeaway: AI ECG Predicts Atrial Fibrillation Risk.. Article Links: Article 1: Finerenone and Cardiovascular Outcomes According to Baseline Kidney Function in Patients With Heart Failure: The FINEARTS-HF Trial. (JACC. Heart failure) Article 2: Efficacy and Safety of Aficamten in Children and Adolescents With Obstructive Hypertrophic Cardiomyopathy: Study Design and Rationale of CEDAR-HCM. (Circulation. Heart failure) Article 3: Artificial intelligence-enabled electrocardiographic sex discordance and the risk of incident atrial fibrillation: a multi-national cohort study. (Heart rhythm) Article 4: High Subcutaneous Nerve Activity in Noise-Associated Ventricular Arrhythmias. (Heart rhythm) Article 5: Temporal Change in Right Ventricular Pacing Ratio and Its Association with Cardiac Function and Arrhythmia: A Linear Mixed-Effects Model Analysis. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/ai-ecg-predicts-atrial-fibrillation-risk-12-07-25/ Featured Articles Article 1: Finerenone and Cardiovascular Outcomes According to Baseline Kidney Function in Patients With Heart Failure: The FINEARTS-HF Trial. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41351608 Summary: Finerenone is established to reduce the risk of worsening heart failure events and cardiovascular death. This benefit applies to patients with heart failure with mildly reduced or preserved ejection fraction. The FINEARTS-HF trial investigated whether this known efficacy of finerenone varies according to a patient’s baseline kidney function. Article 2: Efficacy and Safety of Aficamten in Children and Adolescents With Obstructive Hypertrophic Cardiomyopathy: Study Design and Rationale of CEDAR-HCM. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41347307 Summary: Aficamten, a cardiac myosin inhibitor, improved exercise capacity, health status, and symptoms in adults with obstructive hypertrophic cardiomyopathy, as demonstrated in the phase three SEQUOIA-HCM trial. This medication directly targets the underlying hypercontractility responsible for hypertrophic cardiomyopathy. The CEDAR-HCM trial is evaluating the efficacy and safety of aficamten in children and adolescents with obstructive hypertrophic cardiomyopathy, addressing a critical unmet need given the limited treatment options for pediatric hypertrophic cardiomyopathy. Article 3: Artificial intelligence-enabled electrocardiographic sex discordance and the risk of incident atrial fibrillation: a multi-national cohort study. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41352445 Summary: This study successfully developed and externally validated an artificial intelligence enabled electrocardiogram model for sex prediction. The model achieved an Area Under the Curve of 0.91 on the C. O. D. E. minus 15 percent dataset and 0.90 on the M. I. M. I. C. minus I. V. dataset. This tool generates a sex discordance score, which provides a quantifiable measure related to incident atrial fibrillation risk beyond binary sex classification. Article 4: High Subcutaneous Nerve Activity in Noise-Associated Ventricular Arrhythmias. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41352444 Summary: Environmental noise acts as a contributing factor to cardiovascular disease and arrhythmias, a process linked to autonomic nervous system dysregulation. The mechanisms driving noise-induced arrhythmogenesis remain unclear. Understanding subcutaneous nerve activity and heart rate variability is crucial for elucidating the role of autonomic nervous system modulation in these ventricular arrhythmias. Article 5: Temporal Change in Right Ventricular Pacing Ratio and Its Association with Cardiac Function and Arrhythmia: A Linear Mixed-Effects Model

Welcome to Cardiology Today – Recorded December 06, 2025. This episode summarizes 5 key cardiology studies on topics like Canada and computed tomography angiography. Key takeaway: AI Enables Early Pediatric Heart Dysfunction Detection.. Article Links: Article 1: Digital profile of children’s hearts: automated echocardiogram strain analysis facilitates earlier detection of cardiac dysfunction. (European heart journal) Article 2: The Canadian Heart Failure Society (CHFS) Workforce Committee Report 2024: Addressing the Challenges Facing the Heart Failure Physicians Workforce in Canada CHFS 2024 Heart Failure Workforce Report. (Journal of cardiac failure) Article 3: Tenecteplase vs Alteplase in Mechanical Prosthetic Heart Valve Thrombosis: The TENET Randomized Clinical Trial. (JAMA cardiology) Article 4: Long-term prognostic impact of complete revascularisation defined by CT-derived fractional flow reserve. (Heart (British Cardiac Society)) Article 5: Cardiomyopathy-Associated Pathogenic Variants in Pediatric Myocarditis: A Study From the Pediatric Cardiomyopathy Registry. (Circulation. Heart failure) Full episode page: https://podcast.explainheart.com/podcast/ai-enables-early-pediatric-heart-dysfunction-detection-12-06-25/ Featured Articles Article 1: Digital profile of children’s hearts: automated echocardiogram strain analysis facilitates earlier detection of cardiac dysfunction. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41347951 Summary: A new semi-supervised deep learning framework, the Motion-Echo system, was developed using 11096 paediatric and 11297 adult echocardiograms. This system provides a standardized and vendor-agnostic approach for paediatric myocardial strain analysis. It enhances cardiac function evaluation and enables earlier detection of cardiac impairment, addressing high variance and limited precision in current methods. Article 2: The Canadian Heart Failure Society (CHFS) Workforce Committee Report 2024: Addressing the Challenges Facing the Heart Failure Physicians Workforce in Canada CHFS 2024 Heart Failure Workforce Report. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41349596 Summary: H. F. S.) Workforce Committee Report 2024: Addressing the Challenges Facing the Heart Failure Physicians Workforce in Canada CHFS 2024 Heart Failure Workforce Report. The Canadian Heart Failure Society (C. H. F. S.) Workforce Committee Report identified a critical gap where the heart failure physician workforce in Canada has not grown to meet the rising demand. The committee, comprising 16 Canadian physicians, determined key drivers of this workforce crisis. The report provides actionable solutions to address this growing burden on healthcare resources and patient care. These findings highlight the urgent need for strategic planning to ensure adequate heart failure physician staffing across the country. Article 3: Tenecteplase vs Alteplase in Mechanical Prosthetic Heart Valve Thrombosis: The TENET Randomized Clinical Trial. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41335456 Summary: The TENET Randomized Clinical Trial compared the safety and efficacy of tenecteplase versus standard infusions of alteplase for patients with symptomatic prosthetic valve thrombosis after mechanical heart valve replacement. This study directly assessed the utility of tenecteplase in this patient population, where alteplase is an accepted first-line thrombolytic therapy. The trial provided data on the comparative performance of these two agents in addressing prosthetic valve thrombosis. Article 4: Long-term prognostic impact of complete revascularisation defined by CT-derived fractional flow reserve. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41339021 Summary: T.-derived fractional flow reserve. This prospective multicenter study in 900 patients with new-onset stable angina investigated the lon

Welcome to Cardiology Today – Recorded December 05, 2025. This episode summarizes 5 key cardiology studies on topics like diagnosis and formalin-fixed paraffin-embedded. Key takeaway: First FFPE Heart Rejection Molecular Test Validated. Article Links: Article 1: Safety, Utility, and Outcomes of Procainamide Challenge for the Diagnosis and Exclusion of Brugada Syndrome. (Circulation) Article 2: Heart allograft rejection: molecular diagnosis using intra-graft targeted gene expression profiling. (European heart journal) Article 3: Oestrogen-related receptor γ in sepsis-induced cardiomyopathy: role of cardiomyocyte subtype conversion. (European heart journal) Article 4: Cardiovascular disease in women: traditional and sex-specific risk factors. (European heart journal) Article 5: Impact of left ventricular assist device implantation on right ventricular-pulmonary arterial coupling assessed by high-fidelity hemodynamics. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/first-ffpe-heart-rejection-molecular-test-validated-12-05-25/ Featured Articles Article 1: Safety, Utility, and Outcomes of Procainamide Challenge for the Diagnosis and Exclusion of Brugada Syndrome. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41342099 Summary: This study characterized the safety and diagnostic yield of procainamide infusion for inducing a type one Brugada pattern for Brugada syndrome diagnosis. It established the prognosis associated with a procainamide-induced Brugada pattern, demonstrating differences from other sodium channel blockers. The investigation defined the specific indications for procainamide challenge using data from the Canadian Hearts in Rhythm Organization registry. This established a clearer clinical utility for identifying this particular electrocardiogram pattern. Article 2: Heart allograft rejection: molecular diagnosis using intra-graft targeted gene expression profiling. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41342627 Summary: This study developed and validated the first formalin-fixed, paraffin-embedded tissue-based molecular diagnostic system for heart transplant rejection. The system utilizes intra-graft targeted gene expression profiling to refine diagnostic accuracy. This method is applicable to endomyocardial biopsies and is designed for easy implementation in clinical practice. The international study established a deeply phenotyped cohort of heart transplant recipients to support this validation. Article 3: Oestrogen-related receptor γ in sepsis-induced cardiomyopathy: role of cardiomyocyte subtype conversion. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41342227 Summary: This study identified oestrogen-related receptor gamma as a key regulator in sepsis-induced cardiomyopathy. Researchers found that cardiomyocyte subtype conversion plays a crucial role in the pathophysiology of sepsis-induced cardiomyopathy. This mechanistic insight offers a novel understanding of how sepsis increases overall mortality through cardiac dysfunction. The findings lay a foundation for developing targeted therapies for sepsis-induced cardiomyopathy, addressing a current lack of specific treatments. Article 4: Cardiovascular disease in women: traditional and sex-specific risk factors. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41342194 Summary: This review highlighted that cardiovascular disease accounts for more deaths in women than breast cancer, lung cancer, and chronic lung disease combined, showing comparable mortality to men. It identified a critical lack of awareness among both women and physicians regarding cardiovascular disease as a major cause of morbidity and mortality in women. This contributes to significant delays in diagnosis and treatment. The analysis confirm

Welcome to Cardiology Today – Recorded December 04, 2025. This episode summarizes 5 key cardiology studies on topics like oral magnesium and diabetes mellitus. Key takeaway: TNNT2 Variant Pinpoints Low-Risk Hypertrophic Cardiomyopathy. Article Links: Article 1: Oral magnesium and outcomes in US veterans with heart failure. (European heart journal) Article 2: Diabetes and sudden cardiac death: a Danish nationwide study. (European heart journal) Article 3: Cardiovascular-Kidney-Metabolic Disease Burden in Children and Adults Following Heart Transplantation. (JACC. Heart failure) Article 4: The p.Asn271Ile Variant in the TNNT2 Gene Is Associated With Low-Risk Late-Onset Hypertrophic Cardiomyopathy. (JACC. Heart failure) Article 5: Outcomes After Donation After Circulatory Determination of Death Cardiac Transplantation: An International, Multicenter Retrospective Study. (JACC. Heart failure) Full episode page: https://podcast.explainheart.com/podcast/tnnt2-variant-pinpoints-low-risk-hypertrophic-cardiomyopathy-12-04-25/ Featured Articles Article 1: Oral magnesium and outcomes in US veterans with heart failure. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41338273 Summary: This study identified 54696 United States veterans with Heart Failure between 2001 and 2023 who also presented with hypomagnesemia, defined as serum magnesium below 1.7 milligrams per deciliter. Among this cohort, 10695 patients were initiated on oral magnesium therapy, with a median daily dose of 420 milligrams. A propensity score-matched cohort of 21098 patients was established, allowing for comparison of clinical outcomes between those receiving oral magnesium and those not. The study thus provided the foundational data and a robust comparative structure for evaluating the real-world impact of oral magnesium supplementation in this population. Article 2: Diabetes and sudden cardiac death: a Danish nationwide study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41338249 Summary: This nationwide Danish study included the entire Danish population in 2010 as its cohort for analysis of sudden cardiac death. Sudden cardiac death cases were ascertained using detailed Danish death certificates across the population. The research characterized incidence rates of sudden cardiac death among individuals with type one diabetes and type two diabetes. The study additionally quantified the shortened life expectancy attributed to sudden cardiac death within these specific diabetic populations. Article 3: Cardiovascular-Kidney-Metabolic Disease Burden in Children and Adults Following Heart Transplantation. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41117724 Summary: This study characterized the incidence and prevalence of cardiovascular-kidney-metabolic dysfunction in children and adults following heart transplantation. The research developed an expanded understanding of these specific post-transplant complications. This characterization provides critical information for informing screening and therapeutic strategies to mitigate adverse events in heart transplant recipients. Article 4: The p.Asn271Ile Variant in the TNNT2 Gene Is Associated With Low-Risk Late-Onset Hypertrophic Cardiomyopathy. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40310325 Summary: This study demonstrated a founder effect of the cardiac troponin T gene p.Asn271Ile variant in A Coruña, Spain. It characterized the specific phenotype of the p.Asn271Ile variant. The research compared this phenotype with codon 92 variants, a known hotspot associated with high risk hypertrophic cardiomyopathy. The data indicated that the TNNT2 p.Asn271Ile variant is associated with low-risk late-onset hypertrophic cardiomyopathy. Article 5: Outcomes After Donation After Circulatory Determination of Death Cardiac Transplantation: An International, Multicenter Retrospective Study. Journal: JACC. Heart fail

Welcome to Cardiology Today – Recorded December 03, 2025. This episode summarizes 5 key cardiology studies on topics like exercise capacity and vaccine preventable illness. Key takeaway: Donor Cell-Free DNA Improves Kidney Rejection. Article Links: Article 1: Lung transplant candidates’ quadriceps strength is a modifiable predictor of recovery in exercise capacity after transplantation. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Identification of Donor-recipient Interactions for a Relative Appraisal of Kidney Graft Marginality: A French Multicentric Cohort-based Study. (Transplantation) Article 3: Pregnancy Outcomes Using Assisted Reproductive Technology in Kidney Transplant Recipients. (Transplantation) Article 4: Addressing vaccination coverage among pediatric solid organ transplant candidates and recipients in the post-coronavirus disease 2019 pandemic period of increased vaccine hesitancy. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 5: Donor-derived cell-free DNA significantly improves rejection yield in kidney transplant biopsies. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Full episode page: https://podcast.explainheart.com/podcast/donor-cell-free-dna-improves-kidney-rejection-12-03-25/ Featured Articles Article 1: Lung transplant candidates’ quadriceps strength is a modifiable predictor of recovery in exercise capacity after transplantation. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40480321 Summary: This study found that pre-transplant quadriceps strength is a modifiable predictor of recovery in exercise capacity following lung transplantation. It demonstrated that assessing a candidate’s quadriceps strength provides crucial insight into their rehabilitation potential. The data showed that strengthening this muscle group offers a tangible target for pre-transplant intervention. This directly impacts the trajectory of post-transplant six minute walk distance and overall functional recovery. Article 2: Identification of Donor-recipient Interactions for a Relative Appraisal of Kidney Graft Marginality: A French Multicentric Cohort-based Study. Journal: Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40653616 Summary: This study established that specific recipient characteristics modify the predictive capacity of donor marginality scores for kidney grafts. It identified unique donor-recipient interactions that lead to a more accurate appraisal of kidney graft quality. The findings showed that integrating these interaction factors improved risk stratification for graft failure. This provides a more relative and individualized assessment of marginal kidney grafts, benefiting patient selection and outcomes. Article 3: Pregnancy Outcomes Using Assisted Reproductive Technology in Kidney Transplant Recipients. Journal: Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40611379 Summary: This retrospective cohort study established the outcomes of pregnancy utilizing assisted reproductive technology in women who are kidney transplant recipients. The data provided crucial information on maternal and fetal risks, given that infertility is common and pregnancies are high risk in this patient population. The study drew upon extensive data from the Transplant Pregnancy Registry International, covering conceptions between March 1968 and July 2022. This offers valuable insights for counseling kidney transplant recipients considering assisted reproductive technology for family planning. Article 4: Addressing vaccination coverage among pediatric solid

Welcome to Cardiology Today – Recorded December 03, 2025. This episode summarizes 5 key cardiology studies on topics like H. O. P. E. and C. T. L. A. 4. Key takeaway: Osimertinib Heart Failure Via GATA4-MYLK3 Axis. Article Links: Article 1: Osimertinib induces reversible cardiac dysfunction through the GATA4-MYLK3-MYL2 axis. (European heart journal) Article 2: Trained immunity in cardiovascular disease. (European heart journal) Article 3: Safety and Tolerability of Sotagliflozin Among Kidney Transplant Recipients. (Transplantation) Article 4: Anti-CTLA-4 Treatment Abrogates Co-stimulation Blockade-induced Acceptance of Transgenic Porcine Islets in Humanized Mice. (Transplantation) Article 5: Cardiac Mitochondrial and Electrophysiological Changes in Transplanted Ovine Hearts Following Preservation by Hypothermic Oxygenated Perfusion. (Transplantation) Full episode page: https://podcast.explainheart.com/podcast/osimertinib-heart-failure-via-gata4-mylk3-axis-12-03-25/ Featured Articles Article 1: Osimertinib induces reversible cardiac dysfunction through the GATA4-MYLK3-MYL2 axis. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41330421 Summary: This study found that osimertinib, a third-generation tyrosine kinase inhibitor, induces reversible cardiac dysfunction. The research demonstrated this cardiotoxicity operates through the GATA4-MYLK3-MYL2 axis. This mechanism explains the associated heart failure observed in patients treated with osimertinib for non-small cell lung carcinoma. Understanding this pathway provides a foundation for developing cardioprotective strategies against this drug-induced cardiac damage. Article 2: Trained immunity in cardiovascular disease. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41330410 Summary: Trained immunity, or T. R. I. M., is a recallable, long-term hyperinflammatory innate immune phenotype. This process involves changes in metabolic and epigenetic intracellular processes within mature innate immune cells. Trained immunity is identified as a core mechanism in the pathophysiology of atherosclerosis and represents a potential target for new pharmacological interventions to prevent or treat cardiovascular disease. Article 3: Safety and Tolerability of Sotagliflozin Among Kidney Transplant Recipients. Journal: Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40986618 Summary: Sodium-glucose cotransporter inhibitors effectively slow chronic kidney disease progression and reduce kidney failure events in the general population. These agents are known to cause an initial and sustained decline in estimated glomerular filtration rate and carry an increased risk of urogenital infections. For kidney transplant recipients, who face a high risk of adverse kidney outcomes, the safety and tolerability of this drug class, specifically sotagliflozin, are crucial considerations. Article 4: Anti-CTLA-4 Treatment Abrogates Co-stimulation Blockade-induced Acceptance of Transgenic Porcine Islets in Humanized Mice. Journal: Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40855395 Summary: Previous research demonstrated that beta cell-specific overexpression of a high-affinity variant of human cytotoxic T-lymphocyte-associated antigen 4, or C. T. L. A. 4, prevented porcine islet rejection in humanized mouse models. This study found that anti-cytotoxic T-lymphocyte-associated antigen 4 treatment abrogates the co-stimulation blockade, reversing the acceptance of transgenic porcine islets. This indicates that long-term xenograft function and survival were not maintained following neutralization of C. T. L. A. 4-mediated co-stimulation blockade. Article 5: Cardiac Mitochondrial and Electrophysiological Changes in Transplanted Ovine Hearts Following Preservation by Hypothermic Oxygenated Perfusion. Journal: Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40691830 Summary: Donor hearts experience injury during heart tra

Welcome to Cardiology Today – Recorded December 02, 2025. This episode summarizes 5 key cardiology studies on topics like risk score and heart transplantation. Key takeaway: Heart Transplant Survival Score Developed. Article Links: Article 1: Reducing driveline infection risk in durable mechanical circulatory support devices with ultra-flexible wires for energy transfer. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Clinical outcomes of cardiogenic shock patients supported with VA-ECMO: Insights from the Cardiogenic Shock Working Group. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Development of a risk score predicting survival after adult heart transplantation in the United States. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Out of sequence heart transplants: Why, how many, and to whom. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Lung transplant in patients with suspicious lung lesions: A single-center retrospective data analysis. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/heart-transplant-survival-score-developed-12-02-25/ Featured Articles Article 1: Reducing driveline infection risk in durable mechanical circulatory support devices with ultra-flexible wires for energy transfer. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40714161 Summary: Durable mechanical circulatory support devices are associated with driveline infections, a major burden for heart failure patients. A key contributor to these infections is the low mechanical compliance of current drivelines, which negatively impacts wound healing. The research explores new drivelines equipped with ultra-flexible wires, which are designed to mitigate mechanical stress on the skin. This approach addresses the root cause of wound healing issues, thus offering a strategy to reduce the risk of driveline infections. Article 2: Clinical outcomes of cardiogenic shock patients supported with VA-ECMO: Insights from the Cardiogenic Shock Working Group. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40714159 Summary: A. -E. C. M. O.: Insights from the Cardiogenic Shock Working Group. Veno-arterial extracorporeal membrane oxygenation (V. A. -E. C. M. O.) is used worldwide for cardiogenic shock despite conflicting outcomes from randomized trials that focused on myocardial infarction-related cardiogenic shock. This study, using a multicenter registry, provided a detailed characterization of clinical outcomes for patients with cardiogenic shock supported by V. A. -E. C. M. O. The analysis differentiated outcomes across various cardiogenic shock etiologies, moving beyond a sole focus on myocardial infarction-related cases. This work established a clearer understanding of V. A. -E. C. M. O.’s clinical utility in a broader spectrum of cardiogenic shock patients. Article 3: Development of a risk score predicting survival after adult heart transplantation in the United States. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40691955 Summary: The United States’ system for allocating donor hearts currently prioritizes candidates at highest risk of waiting lis

Welcome to Cardiology Today – Recorded December 02, 2025. This episode summarizes 5 key cardiology studies on topics like Angiotensin-(1-7) and hemocompatibility-related adverse events. Key takeaway: Donation After Circulatory Death Expands Heart Transplant Access.. Article Links: Article 1: Myocardial Work Index as an Indicator of Cardiac Function in Ex Situ Heart Perfusion. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Two-year outcomes in the direct oral anticoagulant apixaban in left ventricular assist devices (DOAC LVAD) study. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Hemodynamic effects of sotatercept administration in pulmonary hypertension- Insights from remote monitoring. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Donation after circulatory death transplantation alleviates waitlist time for hard-to-transplant cardiac recipients. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Angiotensin-(1-7) preconditioning during 10°C static preservation improves early post-transplant graft function in a rat lung transplantation model. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/donation-after-circulatory-death-expands-heart-transplant-access-12-02-25/ Featured Articles Article 1: Myocardial Work Index as an Indicator of Cardiac Function in Ex Situ Heart Perfusion. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40846115 Summary: The study demonstrated that the echocardiographic myocardial work index effectively evaluated cardiac performance in donor hearts during ex situ heart perfusion. This method provides functional assessment of marginal cardiac grafts, which are increasingly relied upon due to organ shortages. The research confirmed that the myocardial work index accurately indicated cardiac function. This functional evaluation contributes to better selection and utilization of donor hearts for transplantation. Article 2: Two-year outcomes in the direct oral anticoagulant apixaban in left ventricular assist devices (DOAC LVAD) study. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40819750 Summary: This study reported 2-year outcomes for apixaban anticoagulation in patients with left ventricular assist devices. Apixaban was previously established as feasible at 6 months without excess hemocompatibility-related adverse events. The current research provided crucial longer-term data regarding apixaban’s safety and efficacy profile in preventing major adverse events in left ventricular assist device recipients. It informed the extended use of apixaban for anticoagulation in this patient population. Article 3: Hemodynamic effects of sotatercept administration in pulmonary hypertension- Insights from remote monitoring. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40769332 Summary: Sotatercept, a recently approved agent, addresses the underlying pathophysiology of pulmonary arterial hypertension by favoring pro-apoptotic pathways within the pulmonary artery. This distinct remodeling mechanism differentiates it from traditional vasodilator therapies. Sotatercept is used as an adjunctive treatment to existin

Welcome to Cardiology Today – Recorded December 01, 2025. This episode summarizes 5 key cardiology studies on topics like donor organ availability and waitlist mortality. Key takeaway: ABOi Heart Transplants Expand Pediatric Pool. Article Links: Article 1: Oxidized Phospholipids, Lipoprotein(a), and Cardiovascular Outcomes after Acute Coronary Syndrome. (Circulation) Article 2: Combined heart-lung organ allocation: A glitch in the system. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: High Antiphospholipid Antibody Titers and Outcomes of Pulmonary Endarterectomy: A Single-Center Retrospective Observational Cohort Study. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Safe Practices: Partial Coverage of Left Ventricular Assist Device Reduces Bleeding Risk during Explant-Heart Transplant without Causing Obstruction. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: ABO-incompatible heart transplants in children aged 2-9 years: A new paradigm in transplant? (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/aboi-heart-transplants-expand-pediatric-pool-12-01-25/ Featured Articles Article 1: Oxidized Phospholipids, Lipoprotein(a), and Cardiovascular Outcomes after Acute Coronary Syndrome. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41321238 Summary: Researchers measured oxidized phospholipids on apolipoprotein B-100 and lipoprotein(a) levels in 11630 participants with acute coronary syndrome. These markers were quantified at baseline, and in 5185 participants four months after randomization to alirocumab or placebo in the ODYSSEY OUTCOMES trial. This comprehensive analysis established the presence and levels of these pro-inflammatory lipid markers in a large cohort of acute coronary syndrome patients undergoing specific contemporary treatment strategies. Article 2: Combined heart-lung organ allocation: A glitch in the system. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40935217 Summary: This study found that patients awaiting combined heart-lung transplantation experience unnecessarily long wait times due to the absence of a specific organ allocation system for this patient population. Researchers observed these prolonged wait times following recent revisions to the United States heart and lung allocation systems. The current guidelines prioritize patients based on waitlist mortality, yet combined heart-lung transplant recipients are not adequately prioritized within these separate systems. Article 3: High Antiphospholipid Antibody Titers and Outcomes of Pulmonary Endarterectomy: A Single-Center Retrospective Observational Cohort Study. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40907841 Summary: This retrospective observational study collected data on patients undergoing pulmonary endarterectomy to investigate outcomes in those with and without antiphospholipid syndrome. The researchers specifically focused on high antiphospholipid antibody titers and their association with post-operative mortality and thrombotic complications. This investigation demonstrated the importance of evaluating antiphospholipid antibody titers for outcomes in chronic thromboembolic pulmonary hypertension patients undergoing surgical intervention. Article 4: Safe Practices: Partial Coverage of Left Ventricular Assist Device Reduces Bleeding Risk durin

Welcome to Cardiology Today – Recorded December 01, 2025. This episode summarizes 5 key cardiology studies on topics like lipid transport and short-term outcomes. Key takeaway: PE Calculator Predicts Short-Term Outcomes. Article Links: Article 1: Deletion of METTL14, a key methylation regulator, attenuates vascular ageing. (European heart journal) Article 2: Excessive glycosylation drives thoracic aortic aneurysm formation through integrated stress response. (European heart journal) Article 3: The macrophage-derived motor protein KIF13B enhances MERTK-mediated efferocytosis and prevents atherosclerosis in mice. (European heart journal) Article 4: Acute pulmonary embolism: a multimarker calculator to predict short-term outcomes. (European heart journal) Article 5: Nuclear receptor Dax1 promotes atherosclerosis by lipid transport inhibition and autophagy suppression in macrophages. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/pe-calculator-predicts-short-term-outcomes-12-01-25/ Featured Articles Article 1: Deletion of METTL14, a key methylation regulator, attenuates vascular ageing. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40758401 Summary: Deletion of methyltransferase-like protein 14 (METTL14) was found to attenuate vascular aging. This suggests that METTL14 plays a role in promoting vascular aging, possibly by influencing inflammation. Modulating METTL14 activity could therefore represent a therapeutic strategy to combat age-related vascular diseases. Article 2: Excessive glycosylation drives thoracic aortic aneurysm formation through integrated stress response. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40720766 Summary: This study found that excessive glycosylation drives the formation of thoracic aortic aneurysms and dissections (TAADs) through activation of the integrated stress response. The hexosamine biosynthetic pathway was identified as a key contributor to this process in both sporadic and genetic forms of thoracic aortic aneurysm. This mechanistic insight suggests that targeting the hexosamine biosynthetic pathway could offer a therapeutic approach for preventing or treating thoracic aortic aneurysms and related conditions such as Marfan syndrome. Article 3: The macrophage-derived motor protein KIF13B enhances MERTK-mediated efferocytosis and prevents atherosclerosis in mice. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40709729 Summary: Kinesin family member 13B (KIF13B), a macrophage-derived motor protein, was found to enhance MERTK-mediated efferocytosis. This enhancement of efferocytosis, which is the clearance of apoptotic cells, resulted in the prevention of atherosclerosis in mice. The data suggests that KIF13B plays a protective role against atherosclerosis by improving cellular waste removal, indicating its potential as a therapeutic target. Article 4: Acute pulmonary embolism: a multimarker calculator to predict short-term outcomes. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40391731 Summary: A multimarker prognostic calculator was developed to predict short-term outcomes in patients with acute pulmonary embolism (P. E.). This calculator estimates the absolute risk of key outcomes for individual patients, utilizing variables from the simplified Pulmonary Embolism Severity Index and other markers. The study validated the calculator’s performance and compared it to the established European Society of Cardiology (E. S. C.) model for risk stratification in acute pulmonary embolism, providing a tool for targeted interventions. Article 5: Nuclear receptor Dax1 promotes atherosclerosis by lipid transport inhibition and autophagy suppression in macrophages. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40259807 Summary: Nuclear receptor Dosage-sensitive sex reversal, adrenal hypoplasia congenita critic

Welcome to Cardiology Today – Recorded November 30, 2025. This episode summarizes 5 key cardiology studies on topics like alloresponse and Pulmonary Vein Isolation. Key takeaway: Sick Sinus Syndrome Raises Stroke Risk in Low-Risk A. F.. Article Links: Article 1: Donor MHC-specific IgE augments the T and B cell alloresponse in a CD23-dependent manner. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 2: Sick Sinus Syndrome Elevates Stroke Risk in Atrial Fibrillation Patients with Low CHA2DS2-VASC Score. (Heart rhythm) Article 3: The Effect of Pulmonary Vein Isolation on Gastric Motility: Pulsed-field Ablation vs Radiofrequency. (Heart rhythm) Article 4: New Technique to Achieve Total Mitral Isthmus Block: Targeting Masked Epicardial Conductions. (Heart rhythm) Article 5: Prevalence, Spectrum and Outcomes in Patients with Non-Penetrant Long QT Syndrome. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/sick-sinus-syndrome-raises-stroke-risk-in-low-risk-a-f-11-30-25/ Featured Articles Article 1: Donor MHC-specific IgE augments the T and B cell alloresponse in a CD23-dependent manner. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317870 Summary: H. C.-specific IgE augments the T and B cell alloresponse in a C. D. 23-dependent manner. Donor Major Histocompatibility Complex-specific Immunoglobulin E augments both T cell and B cell alloresponses in a C. D. 23-dependent manner. This mechanism indicates that Immunoglobulin E, in addition to its known roles in allergic hypersensitivity, contributes to immune activation relevant to transplant rejection. The presence of donor Major Histocompatibility Complex-specific Immunoglobulin E has been observed in murine transplant models and in human kidney transplant recipients. These findings illuminate a previously unrecognized role for Immunoglobulin E in modulating the alloimmune response, suggesting it influences transplant outcomes. Article 2: Sick Sinus Syndrome Elevates Stroke Risk in Atrial Fibrillation Patients with Low CHA2DS2-VASC Score. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317944 Summary: H. A. 2. D. S. 2. -V. A. S. C. Score. Sick Sinus Syndrome elevates stroke risk specifically in patients with Atrial Fibrillation who have a low C. H. A. 2. D. S. 2. -V. A. S. C. score. This finding indicates that concomitant Sick Sinus Syndrome acts as an independent risk factor for incident ischemic stroke, even in patients considered to be at lower risk by conventional scoring systems. The study, which analyzed a cohort of 24960 patients, suggests that clinicians should consider the presence of Sick Sinus Syndrome when assessing stroke risk in Atrial Fibrillation patients. Therefore, Sick Sinus Syndrome requires careful consideration in comprehensive stroke prevention strategies for this patient population. Article 3: The Effect of Pulmonary Vein Isolation on Gastric Motility: Pulsed-field Ablation vs Radiofrequency. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317943 Summary: Pulsed-field Ablation for Pulmonary Vein Isolation demonstrates a superior safety profile regarding gastric motility compared to Radiofrequency Ablation. Radiofrequency Ablation for Pulmonary Vein Isolation was observed to impair gastric motility due to collateral thermal injury. In contrast, Pulsed-field Ablation, being a nonthermal modality, preferentially affected cardiomyocytes and preserved gastric motility in patients with Atrial Fibrillation. This indicates that Pulsed-field Ablation offers a significant advantage in reducing the risk of gastric motility impairment during Pulmonary Vein Isolation procedures. Article 4: New Technique to Achieve Total Mitral Isthmus Block: Targetin

Welcome to Cardiology Today – Recorded November 30, 2025. This episode summarizes 5 key cardiology studies on topics like digital biomarker and wild-type amyloid. Key takeaway: HRV-CV: A Digital Biomarker for Age, Sex, and Behavior. Article Links: Article 1: Clinical phenotype and prognosis of real-world patients with wild-type transthyretin amyloid cardiomyopathy treated with tafamidis. (European journal of heart failure) Article 2: Clinical phenotype and prognosis of real-world patients with wild-type transthyretin amyloid cardiomyopathy treated with tafamidis. (European journal of heart failure) Article 3: Left atrioventricular ratio (LA:LV): Using left ventricular size as the reference for identifying maladaptive left atrial remodelling. (European heart journal. Cardiovascular Imaging) Article 4: Heart Rate Variability Coefficient of Variation During Sleep as a Digital Biomarker That Reflects Behavior and Varies by Age and Sex. (American journal of physiology. Heart and circulatory physiology) Article 5: Mid- and Late-term Left Ventricular Diastolic Function After the Ross Procedure. (Pediatric cardiology) Full episode page: https://podcast.explainheart.com/podcast/hrv-cv-a-digital-biomarker-for-age-sex-and-behavior-11-30-25/ Featured Articles Article 1: Clinical phenotype and prognosis of real-world patients with wild-type transthyretin amyloid cardiomyopathy treated with tafamidis. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317156 Summary: Tafamidis has significantly advanced the treatment paradigm for transthyretin amyloid cardiomyopathy, as demonstrated by results from a phase three randomized controlled trial. However, comprehensive real-world data detailing its use remain limited. A critical need exists to understand the clinical phenotype of patients receiving tafamidis for wild-type transthyretin amyloid cardiomyopathy and its association with survival outside of controlled trial settings. This gap highlights the importance of observational data for characterizing outcomes in diverse patient populations. Article 2: Clinical phenotype and prognosis of real-world patients with wild-type transthyretin amyloid cardiomyopathy treated with tafamidis. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317156 Summary: Tafamidis has significantly advanced the treatment paradigm for transthyretin amyloid cardiomyopathy, as demonstrated by results from a phase three randomized controlled trial. However, comprehensive real-world data detailing its use remain limited. A critical need exists to understand the clinical phenotype of patients receiving tafamidis for wild-type transthyretin amyloid cardiomyopathy and its association with survival outside of controlled trial settings. This gap highlights the importance of observational data for characterizing outcomes in diverse patient populations. Article 3: Left atrioventricular ratio (LA:LV): Using left ventricular size as the reference for identifying maladaptive left atrial remodelling. Journal: European heart journal. Cardiovascular Imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41299774 Summary: The left atrioventricular ratio, defined as the ratio of maximal Left Atrial End-Systolic Volume to Left Ventricular End-Diastolic Volume, provides valuable context for cardiac remodeling assessment. This echocardiography-based measure aids in distinguishing between physiological and pathological cardiac changes. It addresses the critical need to consider the interdependence of left atrial and left ventricular remodeling, a relationship often overlooked in standard clinical practice. Article 4: Heart Rate Variability Coefficient of Variation During Sleep as a Digital Biomarker That Reflects Behavior and Varies by Age and Sex. Journal: American journal of physiology. Heart and circulatory physiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41309064 Summary: The heart rate variability coeff

Welcome to Cardiology Today – Recorded November 29, 2025. This episode summarizes 5 key cardiology studies on topics like Left Ventricular Ejection Fraction and British Columbia. Key takeaway: Pediatric Kidney Transplant: 69% Rehospitalized within Year.. Article Links: Article 1: Association of rehospitalization after pediatric kidney transplantation with kidney function at 1-year post-transplant and long-term allograft failure. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 2: Noninvasive Assessment of Right Ventricular-Pulmonary Arterial Coupling in Repaired Tetralogy of Fallot by Magnetic Resonance Imaging. (Journal of the American Heart Association) Article 3: Left Ventricular Ejection Fraction Response After Atrial Fibrillation Ablation: Clinical Predictors and Development of the PACED Score. (Heart rhythm) Article 4: Road exposure after cardioverter-defibrillator implantation and its potential influence on reported motor vehicle crash risks. (The American journal of cardiology) Article 5: Association of Body Mass Index with ten-year outcomes in asymptomatic stage a/B heart failure patients: Insights from the CHART-2 study. (International journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/pediatric-kidney-transplant-69-rehospitalized-within-year-11-29-25/ Featured Articles Article 1: Association of rehospitalization after pediatric kidney transplantation with kidney function at 1-year post-transplant and long-term allograft failure. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41314615 Summary: This study found that 29 percent of incident pediatric kidney transplant recipients experienced rehospitalization within the first 30 days post-transplant. Furthermore, over two-thirds of children, specifically 69 percent, were rehospitalized within the first year following their transplant procedure. These findings highlight a high burden of early rehospitalizations in pediatric kidney transplant patients, underscoring the need for improved post-transplant care strategies. Article 2: Noninvasive Assessment of Right Ventricular-Pulmonary Arterial Coupling in Repaired Tetralogy of Fallot by Magnetic Resonance Imaging. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294083 Summary: This study evaluated a noninvasive, volume-based parameter for Right Ventricular-Pulmonary Arterial coupling in a cohort of 92 pediatric and 105 adult patients with repaired Tetralogy of Fallot. Right Ventricular-Pulmonary Arterial coupling quantifies right ventricular contractility in relation to its afterload, a crucial measure traditionally requiring high-fidelity catheter-derived pressure-volume loops. The investigation explored this noninvasive parameter’s utility in assessing ventricular function in this patient population, addressing the need for less invasive evaluation methods compared to traditional approaches. Article 3: Left Ventricular Ejection Fraction Response After Atrial Fibrillation Ablation: Clinical Predictors and Development of the PACED Score. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41314586 Summary: This multicenter cohort study identified pre-procedural predictors of Left Ventricular Ejection Fraction response following atrial fibrillation ablation in patients with Left Ventricular Systolic Dysfunction. The study included patients with atrial fibrillation and a Left Ventricular Ejection Fraction less than 50 percent who underwent an index ablation procedure. The study developed the P. A. C. E. D. Score to pragmatically stratify patients for Left Ventricular Ejection Fraction response after ablation. Catheter ablation for atrial fibrillation improves outcomes

Welcome to Cardiology Today – Recorded November 28, 2025. This episode summarizes 5 key cardiology studies on topics like cardiovascular disease and aspirin dosing. Key takeaway: Epigenetic Aging Predicts Cardiovascular Disease. Article Links: Article 1: Altitude-Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study. (Journal of the American Heart Association) Article 2: DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study. (Journal of the American Heart Association) Article 3: Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Chronic Obstructive Pulmonary Disease and Asthma: Insights From ADAPTABLE. (Journal of the American Heart Association) Article 4: Intergenerational Socioeconomic Mobility and Cardiovascular Health Among Hispanic/Latino Youth and Caregivers Living in the United States. (Journal of the American Heart Association) Article 5: Fontan-Associated Liver Disease: Trends Over Time and Relationship With Outcomes. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/epigenetic-aging-predicts-cardiovascular-disease-11-28-25/ Featured Articles Article 1: Altitude-Related Differences in Biventricular Remodeling and the Clinical Profile of Pulmonary Hypertension: An Exploratory Cardiovascular Magnetic Resonance Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294102 Summary: The study compared clinical profiles and biventricular remodeling in patients with pulmonary hypertension residing at high altitudes (2500 meters or greater) versus low altitudes. It revealed distinct patterns of cardiac adaptation and disease progression influenced by hypobaric hypoxia. Understanding these specific altitude-related differences is crucial for developing tailored management strategies. This research provides a foundation for improving outcomes for pulmonary hypertension patients in diverse geographical environments. Article 2: DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294095 Summary: N. A. Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study. This prospective cohort study systematically compared 13 D. N. A. methylation algorithms to assess their relation to incident cardiovascular disease risk in 2112 older adults over a 6-year follow-up. The research clarified the differential utility of various D. N. A. methylation-based aging algorithms in predicting cardiovascular disease. This comparison provides important insights into the most effective epigenetic biomarkers for risk stratification. These findings support the integration of advanced aging algorithms into cardiovascular disease prediction models for older adults. Article 3: Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Chronic Obstructive Pulmonary Disease and Asthma: Insights From ADAPTABLE. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294093 Summary: The ADAPTABLE trial provided specific evidence on the effectiveness and safety of two different aspirin doses for secondary prevention of atherosclerotic cardiovascular disease in patients with chronic obstructive pulmonary disease or asthma. This research demonstrates how optimal antiplatelet therapy differs for individuals with co-existing respiratory conditions, who carry increased cardiovascular risk. The findings inform tailored clinical decisions on aspirin dosing for secondary prevention. This study contributes to refining guideline recommendations for complex cardiovascular patient profiles. Article 4: Intergenerational Socioeconomic Mobility and Ca

Welcome to Cardiology Today – Recorded November 28, 2025. This episode summarizes 5 key cardiology studies on topics like high-sensitivity troponin T and atherosclerotic cardiovascular disease. Key takeaway: Cardiac Amyloidosis Survival Up Over Time.. Article Links: Article 1: A polygenic risk score for peripheral artery disease and major adverse limb events. (European heart journal) Article 2: Small RNA Sequencing of Human Urinary Extracellular Vesicles Reveals Association of High-Sodium Diet With Renal Proinflammatory Pathways. (Journal of the American Heart Association) Article 3: Diagnostic and Prognostic Value of High-Sensitivity Troponin T for Cardiovascular Outcomes in Patients Receiving Immune Checkpoint Inhibitor Therapy. (Journal of the American Heart Association) Article 4: Association Between Monoclonal Gammopathy of Undetermined Significance and Cardiovascular Disease Risk: A Veterans Health Administration Study. (Journal of the American Heart Association) Article 5: Changing Patterns of Diagnosis and Survival in Transthyretin Cardiac Amyloidosis: A Multicenter Cohort Study. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/cardiac-amyloidosis-survival-up-over-time-11-28-25/ Featured Articles Article 1: A polygenic risk score for peripheral artery disease and major adverse limb events. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41312852 Summary: Large-scale genome-wide association studies identified common genetic variants that predict peripheral artery disease risk. This study assessed a specific polygenic risk score for its association with peripheral artery disease and major adverse limb events, independent of other clinical risk factors. The research involved a genetic analysis using individual patient data pooled from six Thrombolysis in Myocardial Infarction trials. This approach demonstrates the method for integrating genetic predisposition into risk stratification for limb-related cardiovascular outcomes. Article 2: Small RNA Sequencing of Human Urinary Extracellular Vesicles Reveals Association of High-Sodium Diet With Renal Proinflammatory Pathways. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294135 Summary: Small RNA sequencing of human urinary extracellular vesicles revealed an association between a high-sodium diet and renal proinflammatory pathways. This study demonstrated that high sodium intake is linked to mechanisms beyond hemodynamic changes, including endothelial dysfunction and oxidative stress. Researchers observed the induction of a proinflammatory milieu in the kidneys. The findings highlight how dietary sodium modulation impacts renal pathophysiology at a molecular level in normotensive subjects. Article 3: Diagnostic and Prognostic Value of High-Sensitivity Troponin T for Cardiovascular Outcomes in Patients Receiving Immune Checkpoint Inhibitor Therapy. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294120 Summary: This study established the diagnostic and prognostic value of high-sensitivity troponin T for cardiovascular outcomes in patients receiving immune-checkpoint inhibitor therapy. Immune-checkpoint inhibitors are known to be associated with adverse cardiac events, with troponin elevation already a diagnostic criterion for immune-checkpoint inhibitor-related myocarditis and myocardial infarction. The research documented additional causes of troponin elevation and their observed outcomes, including cardiac death and heart failure, in these patients. This comprehensive analysis clarified the clinical utility of high-sensitivity troponin T measurements across a broad spectrum of cardiac issues in this specific patient group. Article 4: Association Between Monoclonal Gammopathy of Undetermined Significance and Cardiovascular Disease Risk: A Veterans Health Administration Study. Journal: Journal

Welcome to Cardiology Today – Recorded November 28, 2025. This episode summarizes 5 key cardiology studies on topics like Atherosclerosis and Proinflammatory cytokines. Key takeaway: Aspirin Elimination Safe for HeartMate 3 LVADs. Article Links: Article 1: Impact of Atrial Fibrillation, Diabetes Mellitus and Obesity on Outcomes with Aspirin Avoidance and Hemocompatibility with a Left Ventricular Assist Device: An analysis from the ARIES-HM3 Trial. (Journal of cardiac failure) Article 2: Immune Checkpoint Inhibitors, Atherosclerotic Cardiovascular Events, and Plaque Progression Among Women With Cancer. (Journal of the American Heart Association) Article 3: Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment. (Journal of the American Heart Association) Article 4: Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa. (Journal of the American Heart Association) Article 5: Intracellular Osteopontin of Macrophages Promotes Carotid Plaques Formation by Inducing Foam Cells and Releasing Proinflammatory Cytokines. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/aspirin-elimination-safe-for-heartmate-3-lvads-11-28-25/ Featured Articles Article 1: Impact of Atrial Fibrillation, Diabetes Mellitus and Obesity on Outcomes with Aspirin Avoidance and Hemocompatibility with a Left Ventricular Assist Device: An analysis from the ARIES-HM3 Trial. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41308860 Summary: The ARIES-HM3 trial confirmed the safety and effectiveness of aspirin elimination from the antithrombotic regimen following HeartMate 3 Left Ventricular Assist Device implantation. This specific analysis determined the interaction of atrial fibrillation, diabetes mellitus, and obesity with aspirin elimination regarding hemocompatibility-related adverse events at one year post-implant. The trial randomized patients with a HeartMate 3 Left Ventricular Assist Device to receive aspirin or placebo. This investigation informs personalized antithrombotic management for patients with these common comorbidities. Article 2: Immune Checkpoint Inhibitors, Atherosclerotic Cardiovascular Events, and Plaque Progression Among Women With Cancer. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294143 Summary: Immune checkpoint inhibitors are associated with a three-fold risk of atherosclerotic cardiovascular disease. This single-center retrospective study demonstrated factors associated with atherosclerotic cardiovascular disease in women following immune checkpoint inhibitor therapy. The investigation also characterized plaque progression specifically among women with cancer receiving these treatments. Article 3: Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294142 Summary: The loss of endothelial Yes Associated Protein 1 and WW Domain Containing Transcription Regulator 1 reduced the size of chronic stroke lesions and altered the endothelial environment. This study revealed that brain endothelial cells play a critical role in determining stroke outcomes. The findings indicate a potential therapeutic target for ischemic stroke, a leading cause of morbidity and mortality. Article 4: Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294140 Summary: Plasma from patients with severe aortic stenosis had a detrimental effect on valvular endothelial cells. This effect included inducing oxidative stress and contributin

Welcome to Cardiology Today – Recorded November 28, 2025. This episode summarizes 5 key cardiology studies on topics like abdominal aortic aneurysm and diabetic cardiomyopathy. Key takeaway: Cell-Free DNA Predicts LVAD Outcomes. Article Links: Article 1: Neutrophil extracellular traps and peptidylarginine deiminase 4-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure. (European heart journal) Article 2: Cell-Free DNA Profiles End-Organ Injury and Predicts Outcomes in Advanced Heart Failure With Left Ventricular Assist Device Implantation. (Circulation. Heart failure) Article 3: Immune Cell Type-Specific DNA Methylation Regions Associate With 24-Hour Blood Pressure Regulation in Black People. (Journal of the American Heart Association) Article 4: Vascular and Neural Transcriptomics Reveal Stage-Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension. (Journal of the American Heart Association) Article 5: C-C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/cell-free-dna-predicts-lvad-outcomes-11-28-25/ Featured Articles Article 1: Neutrophil extracellular traps and peptidylarginine deiminase 4-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41307910 Summary: This study demonstrated that neutrophil extracellular traps (NETs) and peptidylarginine deiminase 4 (PAD4)-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure. Endomyocardial biopsies from heart failure patients showed the presence of NETs, indicating their role in human disease pathology. Research involving wild-type and PAD4-deficient mice further elucidated this connection in diabetic cardiomyopathy and kidney disease. This establishes a critical mechanistic link between diabetes and its severe cardiovascular and renal complications. Article 2: Cell-Free DNA Profiles End-Organ Injury and Predicts Outcomes in Advanced Heart Failure With Left Ventricular Assist Device Implantation. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41307146 Summary: This study demonstrated that plasma cell-free DNA (cfDNA) accurately profiles end-organ injury and predicts outcomes in patients with advanced heart failure receiving left ventricular assist device (LVAD) implantation. The research identified cfDNA as a valuable biomarker for risk stratification following LVAD placement. It analyzed a multicenter prospective cohort of heart failure patients, including those with and without LVADs, to establish this predictive capability. This finding offers a novel approach to assess adverse events and improve risk management in this patient population. Article 3: Immune Cell Type-Specific DNA Methylation Regions Associate With 24-Hour Blood Pressure Regulation in Black People. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294148 Summary: This study found that immune cell type-specific DNA methylation regions associate with 24-hour blood pressure regulation in Black people. Researchers established this connection by employing advanced deconvolution algorithms to analyze reduced representation bisulfite sequencing data. The study identified specific epigenetic markers within immune cells that play a role in blood pressure control. These findings highlight a novel mechanism linking immune cell epigenetics to hypertension risk within this specific population. Article 4: Vascular and Neural Transcriptomics Reveal Stage-Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41294147 Summary: This study revealed stage-dependent

Welcome to Cardiology Today – Recorded November 27, 2025. This episode summarizes 5 key cardiology studies on topics like Gene expression profiling and Graft survival. Key takeaway: New Tests Predict Heart Transplant Risk. Article Links: Article 1: Trends in Prevalence, Treatment, and Control of Cardiometabolic Risk Factors Among Adults With Hypertension in the United States, 1999-2023. (Journal of the American College of Cardiology) Article 2: Multimodal Molecular Testing Provides Prognostic Value for Heart Transplant Recipients. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Results of the MACiTEPH study of macitentan for the treatment of inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Enhancement of suppressive function of Ly49+ CD8+ T cells in allogeneic immunity by CD80/86-CD28 blockade in mouse. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Fifty-Year Pediatric Heart Transplant Outcomes: A Pediatric-Adult Center Linked Analysis. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/new-tests-predict-heart-transplant-risk-11-27-25/ Featured Articles Article 1: Trends in Prevalence, Treatment, and Control of Cardiometabolic Risk Factors Among Adults With Hypertension in the United States, 1999-2023. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41295934 Summary: The United States observed a sharp increase in hypertension-related deaths over the past decade, underscoring the need for public health strategies. This study identified 21822 adults with hypertension from 1999 to 2023 through the National Health and Nutrition Examination Survey. Researchers collected data on changes in age-adjusted prevalence of diabetes and other cardiometabolic risk factors within this population. The analysis of these trends offers critical insights into the evolving landscape of hypertension management. Article 2: Multimodal Molecular Testing Provides Prognostic Value for Heart Transplant Recipients. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41297735 Summary: Multimodal molecular testing with gene expression profiling and donor-derived cell-free deoxyribonucleic acid demonstrated prognostic value for heart transplant recipients. This study evaluated 1934 patients from the Surveillance HeartCare Outcomes Registry. Researchers assessed risk based on the most abnormal test results between two and six months post-transplant. The evaluation provided insights into the joint ability of these molecular tests to predict future clinical events, such as graft dysfunction. Article 3: Results of the MACiTEPH study of macitentan for the treatment of inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41297734 Summary: The MACiTEPH study evaluated macitentan 75 milligrams once daily for treating inoperable or persistent or recurrent chronic thromboembolic pulmonary hypertension. This prospective, double-blind, placebo-controlled, phase three study randomized adult patients one to one to macitentan or placebo. The patient population included individuals with chronic thromboembolic pulmonary hypertension, with or without balloon pulmonary angioplasty, or after pulmonar