Welcome to Cardiology Today – Recorded November 18, 2025. This episode summarizes 5 key cardiology studies on topics like precision medicine and temporal trends. Key takeaway: Cirrhotic Cardiomyopathy Predicts Post-Transplant Heart Failure. Article Links: Article 1: CD4+ Tregs Regulate Heart Growth and Regeneration Through MRG15/TIP60-Mediated Epigenomic Remodeling in Proliferating Cardiomyocytes. (Circulation) Article 2: Temporal trends in the use of oral anticoagulants and clinical outcomes in older, elderly, and very elderly patients with atrial fibrillation: a Danish nationwide study. (European heart journal) Article 3: Automated patch clamp data improve variant classification and penetrance stratification for SCN5A-Brugada syndrome. (European heart journal) Article 4: Cirrhotic Cardiomyopathy Predicts New-onset Heart Failure Within the First Year After Liver Transplantation. (Transplantation) Article 5: Role of physician assistants and their impact on cardiology specialty training in the United Kingdom. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/cirrhotic-cardiomyopathy-predicts-post-transplant-heart-failure-11-18-25/ Featured Articles Article 1: CD4+ Tregs Regulate Heart Growth and Regeneration Through MRG15/TIP60-Mediated Epigenomic Remodeling in Proliferating Cardiomyocytes. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41251000 Summary: The study demonstrated that CD4 positive T regulatory cells regulate heart growth and regeneration. This regulation occurs through M. R. G. fifteen / T. I. P. sixty mediated epigenomic remodeling within proliferating cardiomyocytes. The chromatin regulatory network was found to be crucial in orchestrating the dynamic changes in gene expression for the regenerative response in the neonatal heart. These findings provide a deeper understanding of the mechanisms controlling heart regeneration, which is critical for addressing limited regenerative capacity in the adult mammalian heart. Article 2: Temporal trends in the use of oral anticoagulants and clinical outcomes in older, elderly, and very elderly patients with atrial fibrillation: a Danish nationwide study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41251006 Summary: This nationwide Danish study analyzed temporal trends in the use of oral anticoagulants and associated clinical outcomes in older patients with new-onset atrial fibrillation. The study found that anticoagulation therapy patterns in patients with atrial fibrillation have evolved significantly over time, especially following the introduction of direct oral anticoagulants. The analysis investigated how these changes in anticoagulant uptake have impacted clinical outcomes across older adults (65-74 years), elderly (75-84 years), and very elderly (85 years and older) patient groups. This provides critical information on how treatment strategies and patient prognoses for atrial fibrillation have shifted in an aging population. Article 3: Automated patch clamp data improve variant classification and penetrance stratification for SCN5A-Brugada syndrome. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41251004 Summary: The study demonstrated that automated patch clamp data significantly improves the classification of S. C. N. five A variants and penetrance stratification for Brugada Syndrome. This approach addresses complications in genetic workup arising from S. C. N. five A variants of uncertain significance and incomplete penetrance. The deployment of an S. C. N. five A Brugada Syndrome functional assay at a cohort scale was found to facilitate the implementation of genetic and precision medicine for this inherited arrhythmia disorder. These findings refine the diagnostic and risk stratification process for the approximately 20 percent of Brugada Syndrome patients with rare S. C. N. five A variants. Article 4: Cirrhotic Cardiomyopathy Predicts