Welcome to Cardiology Today – Recorded November 15, 2025. This episode summarizes 5 key cardiology studies on topics like Transcatheter aortic valve replacement and Heart failure. Key takeaway: PA-Led Heart Transplant Recovery: Safe, Effective. Article Links: Article 1: Implementation of a Physician Assistant-Led Recovery Model for Heart Transplantation: Clinical Outcomes and Programmatic Benefits at a High-Volume Center. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 2: Effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition in chronic coronary disease: a subanalysis of the LoDoCo2 trial. (Heart (British Cardiac Society)) Article 3: Incidence, predictors and clinical impact of upper gastrointestinal bleeding after transcatheter aortic valve replacement. (Heart (British Cardiac Society)) Article 4: Incidence, predictors and outcomes of tricuspid regurgitation progression after left-sided valvular intervention. (Heart (British Cardiac Society)) Article 5: Determinants of diuresis/natriuresis following ambulatory intravenous loop diuretics for worsening heart failure. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/pa-led-heart-transplant-recovery-safe-effective-11-15-25/ Featured Articles Article 1: Implementation of a Physician Assistant-Led Recovery Model for Heart Transplantation: Clinical Outcomes and Programmatic Benefits at a High-Volume Center. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41238023 Summary: This observational cohort study assessed the clinical outcomes and programmatic benefits of a physician assistant-led allograft recovery model for adult heart transplantation. Researchers compared 130 transplantations using physician assistant teams with 367 using non-physician assistant teams at a high-volume center between 2020 and 2024. The implementation of this physician assistant-led model for donor organ recovery demonstrated comparable clinical outcomes for heart transplantation recipients. This model offers significant programmatic advantages, potentially enhancing efficiency and resource utilization within heart transplantation programs. Article 2: Effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition in chronic coronary disease: a subanalysis of the LoDoCo2 trial. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40393691 Summary: This subanalysis of the Low-Dose Colchicine 2 Trial aimed to investigate the effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition. Researchers performed cross-sectional computed tomography angiography studies in 151 participants with chronic coronary disease. The primary objective was to understand the underlying mechanisms by which low-dose colchicine, administered at 0.5 mg once daily, reduces the risk of major cardiovascular events. This study established a methodology to assess how colchicine may exert its beneficial anti-inflammatory actions on coronary arteries. Article 3: Incidence, predictors and clinical impact of upper gastrointestinal bleeding after transcatheter aortic valve replacement. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40348411 Summary: This prospective registry study investigated the incidence, predictors, and clinical impact of late upper gastrointestinal bleeding following transcatheter aortic valve replacement. Researchers analyzed 3144 patients, stratifying them based on the occurrence of upper gastrointestinal bleeding within one year of hospital discharge. The study characterized the frequency of this complication in transcatheter aortic valve replacement patients and identi