Welcome to Cardiology Today – Recorded November 11, 2025. This episode summarizes 5 key cardiology studies on topics like congenital heart disease and transmitral mean pressure gradient. Key takeaway: Optimize Mitral Repair: Gradients & Regurgitation. Article Links: Article 1: Therapy for Atrial Fibrillation in Patients with Drug-Eluting Stents. (The New England journal of medicine) Article 2: Safety of Using Risk Stratification Along With High-Sensitivity Cardiac Troponin in the Emergency Department: A Secondary Analysis. (Journal of the American College of Cardiology) Article 3: Placental Malperfusion Is Associated With Adverse Outcomes in Congenital Heart Disease and With Genetic Variants in Placental Developmental Pathways. (Journal of the American College of Cardiology) Article 4: Using Transmitral Pressure Gradients and Residual Mitral Regurgitation to Optimize Outcome After Transcatheter Edge-to-Edge Repair. (Journal of the American College of Cardiology) Article 5: Computed Tomography Angiography or Standard Care After Left Main PCI? (Journal of the American College of Cardiology) Full episode page: https://podcast.explainheart.com/podcast/optimize-mitral-repair-gradients-regurgitation-11-11-25/ Featured Articles Article 1: Therapy for Atrial Fibrillation in Patients with Drug-Eluting Stents. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41211917 Summary: This multicenter, randomized, open-label, noninferiority trial in South Korea investigated non-vitamin K antagonist oral anticoagulant monotherapy compared to combination therapy. The study enrolled patients with atrial fibrillation who had received a drug-eluting stent at least one year prior. This research aims to provide crucial data to guide antithrombotic management after drug-eluting stent implantation in patients with atrial fibrillation, addressing current limitations in evidence-based guidelines. The primary objective is to determine if non-vitamin K antagonist oral anticoagulant monotherapy is noninferior to combination therapy for these specific patients. Article 2: Safety of Using Risk Stratification Along With High-Sensitivity Cardiac Troponin in the Emergency Department: A Secondary Analysis. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41193094 Summary: This study conducted a secondary analysis to evaluate the effectiveness and safety of risk stratification using high-sensitivity cardiac troponin in the emergency department. While high-sensitivity cardiac troponin pathways are known to reduce length of stay and hospital admissions for myocardial infarction rule-out, this research aimed to confirm these benefits across low and intermediate risk patients. It also sought to ascertain if patients discharged were accurately identified as having a low risk of future cardiovascular events, thereby ensuring patient safety and appropriate resource utilization. Article 3: Placental Malperfusion Is Associated With Adverse Outcomes in Congenital Heart Disease and With Genetic Variants in Placental Developmental Pathways. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41193091 Summary: This study investigated the impact of placental malperfusion on outcomes in fetuses diagnosed with congenital heart disease. It aimed to determine if congenital heart disease fetuses with placental malperfusion experience adverse outcomes and exhibit genomic variations in shared vascular or placental developmental pathways. This research contributes to understanding the complex interplay between placental health and fetal cardiac development, potentially identifying novel risk factors and mechanisms. This foundational work could lead to improved risk stratification and targeted interventions for congenital heart disease. Article 4: Using Transmitral Pressure Gradients and Residual Mitral Regurgitation to Optimize Outcome After T