Welcome to Cardiology Today – Recorded November 13, 2025. This episode summarizes 5 key cardiology studies on topics like pediatric cardiology and subclinical atrial fibrillation. Key takeaway: N-Palmitoyl Glutamine: Fitness Mediator. Article Links: Article 1: Quantitative Identification of High-Risk Tricuspid Regurgitation by Cardiac Magnetic Resonance. (Circulation) Article 2: N-Palmitoyl Glutamine Is a Candidate Mediator of Cardiorespiratory Fitness. (Circulation) Article 3: Cellular and molecular imaging of coronary atherosclerosis: clinical applications. (European heart journal) Article 4: Contemporary Waitlist and Post-Heart Transplant Outcomes for Fontan patients: An International Multi-Institutional Analysis. (Journal of cardiac failure) Article 5: Major Bleeding With Apixaban vs Aspirin: A Subanalysis of the ARTESiA Randomized Clinical Trial. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/n-palmitoyl-glutamine-fitness-mediator-11-13-25/ Featured Articles Article 1: Quantitative Identification of High-Risk Tricuspid Regurgitation by Cardiac Magnetic Resonance. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41221593 Summary: This study aimed to assess the prognostic relevance of tricuspid regurgitation quantification and its consequences using cardiac magnetic resonance in a large real-world cohort. Researchers collected comprehensive clinical, echocardiographic, and cardiac magnetic resonance data from patients referred between 2019 and 2024 who underwent tricuspid regurgitant fraction quantification. The study established that cardiac magnetic resonance quantification can quantitatively identify high-risk tricuspid regurgitation patients. This provides a crucial tool for improved risk stratification and management strategies for individuals with tricuspid regurgitation. Article 2: N-Palmitoyl Glutamine Is a Candidate Mediator of Cardiorespiratory Fitness. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41221589 Summary: This study investigated the molecular underpinnings of cardiorespiratory fitness, a key predictor of survival and cardiometabolic health. Researchers employed nontargeted liquid chromatography-mass spectrometry-based plasma metabolomics in 654 participants from the HERITAGE Family Study. The study successfully identified N-Palmitoyl Glutamine as a candidate mediator of cardiorespiratory fitness. This discovery provides a novel molecular target for understanding and potentially enhancing cardiorespiratory health and its benefits. Article 3: Cellular and molecular imaging of coronary atherosclerosis: clinical applications. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41222955 Summary: This article reviewed the substantive advances in non-invasive and invasive structural imaging techniques used to delineate atheroma burden and anatomical composition in coronary artery disease. Driven by progress in imaging agent and hardware technology, the review detailed the burgeoning field of cellular and molecular imaging. It comprehensively discussed how these advancements enhance understanding of atherosclerosis pathogenesis and explored their diverse clinical applications. This provides clinicians with critical insights into improved diagnostic capabilities and potential for more targeted therapeutic strategies. Article 4: Contemporary Waitlist and Post-Heart Transplant Outcomes for Fontan patients: An International Multi-Institutional Analysis. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41224169 Summary: This international multi-institutional study provided contemporary data on waitlist and post-heart transplant outcomes for pediatric patients with Fontan circulation. Researchers conducted a retrospective analysis of children aged 2 to less than 18 years listed for heart transplant in the Pediatric Heart Transplant Society database between 1993 and 2023. The study categorized