Welcome to Cardiology Today – Recorded November 20, 2025. This episode summarizes 5 key cardiology studies on topics like angiography and heart failure hospitalization. Key takeaway: Aspirin Elimination Cuts LVAD Bleeding Risk. Article Links: Article 1: Cardiac endogenous transmitter system: molecular features, functions, and clinical implications. (European heart journal) Article 2: Optical coherence tomography-guided stent optimization for complex coronary lesions: the OCCUPI trial. (European heart journal) Article 3: Phase I Randomized Study of Cardiac Stem Cells in Patients With Hypoplastic Left Heart Syndrome: The CHILD Trial. (JACC. Heart failure) Article 4: Hemocompatibility Outcomes With Pharmacological Therapy Following LVAD Implantation: Insights From the ARIES-HM3 Trial. (JACC. Heart failure) Article 5: Heart Failure With Preserved Ejection Fraction Across the Spectrum of Body Mass Index: Hemodynamic and Echocardiographic Characteristics and Outcomes. (JACC. Heart failure) Full episode page: https://podcast.explainheart.com/podcast/aspirin-elimination-cuts-lvad-bleeding-risk-11-20-25/ Featured Articles Article 1: Cardiac endogenous transmitter system: molecular features, functions, and clinical implications. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41259103 Summary: Recent studies have identified several endogenous transmitter systems within cardiomyocytes and cardiac pacemaker cells, overturning the traditional belief that the heart lacked its own intrinsic signaling networks. These systems represent molecular networks that facilitate signal transmission directly within cardiac tissues. This discovery reveals that the heart possesses its own distinct intrinsic networks for transmitting signals. The findings provide novel insights into cardiac physiology and potential targets for therapeutic interventions. Article 2: Optical coherence tomography-guided stent optimization for complex coronary lesions: the OCCUPI trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41259082 Summary: The OCCUPI trial investigated the impact of optical coherence tomography guidance compared to angiography guidance in patients with complex coronary lesions. This study classified patients who underwent optical coherence tomography-guided percutaneous coronary intervention into two groups based on meeting specific optimization criteria. This classification system enabled the detailed evaluation of the incidence, determinants, and clinical impact of stent optimization. The trial established a structured approach for assessing optimal stent placement using advanced imaging techniques. Article 3: Phase I Randomized Study of Cardiac Stem Cells in Patients With Hypoplastic Left Heart Syndrome: The CHILD Trial. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41258851 Summary: Patients with hypoplastic left heart syndrome frequently experience severe right ventricle dysfunction, often leading to shortened lifespans. Neonatal cardiac progenitor cells previously demonstrated improved right ventricle performance in animal models of pressure-overload induced dysfunction. The C. H. I. L. D. trial, a phase one randomized study, specifically applied this therapeutic strategy to patients with hypoplastic left heart syndrome. This trial represents a key step in evaluating autologous neonatal cardiac progenitor cells for enhancing right ventricle function in this vulnerable pediatric group. Article 4: Hemocompatibility Outcomes With Pharmacological Therapy Following LVAD Implantation: Insights From the ARIES-HM3 Trial. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41258850 Summary: The Antiplatelet Removal and Hemocompatibility Events With the HeartMate three Pump trial demonstrated both safety and decreased bleeding by eliminating aspirin from the antithrombotic regimen for patients implanted with a HeartMate three left ventricular as