Welcome to Cardiology Today – Recorded November 12, 2025. This episode summarizes 5 key cardiology studies on topics like monotherapy and exercise hemodynamics. Key takeaway: Angina Endotypes: Precision Treatment Advances. Article Links: Article 1: miR-499 in Platelet-Derived Extracellular Vesicles Augments Inflammatory Cell Generation and Cardiac Remodeling After Myocardial Infarction. (Circulation) Article 2: Enhanced antigen presentation by macrophages promotes human atherosclerosis progression: therapeutic implications. (European heart journal) Article 3: Endotypes of angina with non-obstructive coronary arteries: a prospective multicentre study. (European heart journal) Article 4: Aspirin or P2Y12 inhibitor monotherapy in atherosclerotic cardiovascular disease? (European heart journal) Article 5: Association of Moderate to Severe Tricuspid Regurgitation With Exercise Hemodynamics and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction: Multicenter Study. (Journal of cardiac failure) Full episode page: https://podcast.explainheart.com/podcast/angina-endotypes-precision-treatment-advances-11-12-25/ Featured Articles Article 1: miR-499 in Platelet-Derived Extracellular Vesicles Augments Inflammatory Cell Generation and Cardiac Remodeling After Myocardial Infarction. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41208706 Summary: This study investigated the mechanisms by which myocardial infarction triggers myelopoiesis and exacerbates disease pathology. Researchers induced myocardial infarction in mice and found that platelet-derived extracellular vesicles containing micro-R. N. A. minus 499 augmented inflammatory cell generation and cardiac remodeling. This discovery indicates that micro-R. N. A. minus 499 from platelet extracellular vesicles plays a critical role in promoting adverse cardiac remodeling and identifies a potential therapeutic target. Article 2: Enhanced antigen presentation by macrophages promotes human atherosclerosis progression: therapeutic implications. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41217874 Summary: This research explored the role of adaptive immune responses in human atherosclerosis progression. Using R. N. A. sequencing and immunohistochemistry on human atherosclerotic plaques, the study revealed that enhanced antigen presentation by macrophages promotes the disease. This finding highlights the critical involvement of macrophage-driven immune responses in atherosclerosis pathology and suggests novel therapeutic strategies targeting this pathway. Article 3: Endotypes of angina with non-obstructive coronary arteries: a prospective multicentre study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41214896 Summary: This prospective multicenter study aimed to better diagnose and treat angina with non-obstructive coronary arteries, a prevalent myocardial ischemic syndrome. Researchers enrolled consecutive patients undergoing coronary functional testing across nine centers to identify distinct hemodynamic endotypes. The study successfully stratified patients into these endotypes, demonstrating differential responses to specific treatments and thereby establishing a foundation for a precision medicine approach. Article 4: Aspirin or P2Y12 inhibitor monotherapy in atherosclerotic cardiovascular disease? Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41211721 Summary: While aspirin has been the traditional cornerstone antiplatelet therapy, the review highlights emerging evidence suggesting P2Y12 inhibitors may be more than just an alternative. The findings suggest that P2Y12 inhibitors may be preferred over aspirin as a single antiplatelet agent, offering a significant therapeutic consideration for clinicians. Article 5: Association of Moderate to Severe Tricuspid Regurgitation With Exercise Hemodynamics and Outcomes in Patients With Heart Failure With Preserved E