Alzheimer's disease (AD) is linked to aging and errors in how our genes are processed, a mechanism known as dysfunctional alternative RNA splicing (ASEs). The metabolite NAD+ is known to slow AD progression in preclinical studies.

This 2025 study in Science Advances provides a new mechanism . Researchers found that NAD+ augmentation corrects these harmful splicing errors. It appears to do this by regulating a key protein called EVA1C, which the study found is reduced in the hippocampus of human AD patients compared to cognitively normal ones.

Using mouse models with AD-like tau pathology , supplementing with NAD+ precursors (like NR or NMN) improved memory . Critically, when the researchers blocked the EVA1C protein (via adeno-associated virus-based knockdown) in the mice's hippocampus, the memory improvements from NAD+ were lost .

This suggests the NAD+-EVA1C splicing axis is a critical pathway for how NAD+ protects the brain, offering a potential new target for future AD therapies.

3. Disclaimers

• This information is for educational purposes only and should not be interpreted as medical advice.

• The study discussed was conducted on human cells , C. elegans (worms) , and mouse models . Further research is needed to confirm these specific mechanisms in humans.

• Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.

Ai R, Mao L, Jin X, et al. NAD+ reverses Alzheimer's neurological deficits via regulating differential alternative RNA splicing of EVA1C. Sci Adv. 2025;11(eady9811).

#AlzheimersResearch #NAD #EVA1C #RNASplicing #Neuroscience

NAD+, Alzheimer's disease, EVA1C, alternative RNA splicing, ASEs, hTau.P301S, C. elegans, neuroprotection, neurological deficits, memory improvement, nicotinamide adenine dinucleotide, nicotinamide riboside, nicotinamide mononucleotide, tauopathy, hippocampus, spliceosome, neuronal resilience, transcriptomics, Science Advances, Ai et al 2025, HSP70, BAG1, gene regulation, NAD+-EVA1C splicing axis, neurodegeneration

Collectively, the results of this study position A. conyzoides as a promising, safe, and well-tolerated adjunct or alternative to current pharmacological approaches. Further investigations of longer duration and larger sample sizes, incorporating imaging measures, are warranted to confirm efficacy.

A plant commonly known as "billygoat weed" (Ageratum conyzoides) has a long tradition of use in ethnomedicine for a wide range of conditions, including rheumatism, inflammatory pain, fever, and headaches.

Building on this history, a recent 12-week, double-blind, randomized, placebo-controlled study investigated its effect on osteoarthritis (OA) symptoms in ageing adults. The study included 70 adults aged 45 and older with clinically diagnosed osteoarthritis. Participants were given either 250 mg of a special pyrrolizidine alkaloid-free A. conyzoides extract or a placebo to take daily for 12 weeks.

Researchers found that the group taking A. conyzoides had statistically significant reductions in their total WOMAC scores (a measure of pain, stiffness, and function) compared to the placebo group at both week 9 and week 12. Pain scores, measured by the Visual Analogue Scale (VAS), were also significantly lower for the supplement group at weeks 9 and 12.

Furthermore, the A. conyzoides group showed significant improvements in quality-of-life domains related to pain and role limitations due to physical health. The supplement also significantly reduced plasma levels of two inflammatory markers, IL-6 and IL-8, compared to placebo. The study concluded that A. conyzoides supplementation is a safe and effective option for reducing osteoarthritis symptoms.

3. Disclaimers

• This information is for educational purposes only and should not be interpreted as medical advice.

• The study discussed was conducted on human adults aged 45 and older with clinically diagnosed mild-to-moderate osteoarthritis. The findings may not apply to individuals with severe OA or other conditions.

• Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.

________________________________________

Rao A, Gorman A, Subah S, Muntha S, Bogoda N, Briskey D. Effect of Ageratum Conyzoides on Osteoarthritis in an Ageing Adult Population: A Double-Blind Randomized Placebo-Controlled Parallel Study. Nutraceuticals. 2025;5(4):35. doi:10.3390/nutraceuticals5040035

#AgeratumConyzoides #Osteoarthritis #JointPainRelief #ClinicalTrial #AntiInflammatory

Ageratum conyzoides, osteoarthritis, OA, joint pain, joint stiffness, joint function, WOMAC, Visual Analogue Scale, SF-36, quality of life, IL-6, IL-8, inflammatory markers, nutraceuticals, anti-inflammatory, analgesic, billygoat weed, randomized controlled trial, placebo-controlled study, ageing adult population, pyrrolizidine alkaloid-free, herbal medicine, alternative medicine, osteoarthritis treatment, Gencor Pacific Ltd

📰 Summary

A recent study published in Nutrients investigated the effects of dark chocolate (DC) on anaerobic sprint performance. The study involved twenty healthy participants who completed a randomized, single-blinded experiment.

Participants completed two trials: one after consuming DC milk and another after consuming an iso-caloric white chocolate (WC) milk, which served as a flavonoid-free control. In each trial, they performed a Running Anaerobic Sprint Test (RAST), which consisted of two sets of six 35-meter sprints.

The results showed that DC supplementation significantly improved performance in the second set of sprints:

• Faster Average Sprint Time: 6.43 s (DC) vs. 6.62 s (WC) (p=0.012).

• Faster Total Effort Time: 38.58 s (DC) vs. 39.72 s (WC) (p=0.012).

• Higher Mean Power: 354.09 W (DC) vs. 323.81 W (WC) (p=0.009).

Additionally, during the first set of sprints, participants had a significantly lower (better) fatigue index after consuming DC (30.71%) compared to WC (38.67%) (p=0.006).

⚠️ Disclaimers

• This information is for educational purposes only and should not be interpreted as medical or nutritional advice.

• The study discussed was conducted on a small sample of 20 healthy adults. These findings may not apply to everyone, nor do they reflect long-term effects.

• Always consult with a qualified healthcare professional before making any changes to your diet, supplementation, or training regimen.

📜 Citation

Balasekaran, G.; Ng, Y.C.; Foong, S.; Ong, X.R.R.; Boey, P. Effects of Dark Chocolate on Physiological and Anaerobic Performance Among Healthy Female and Male Adults. Nutrients 2025, 17, 3317. https://doi.org/10.3390/nu17213317

#DarkChocolate #AnaerobicPerformance #SprintTest #ExerciseScience #SportsNutrition

Dark chocolate, anaerobic performance, RAST, running anaerobic sprint test, flavonoids, epicatechin, theobromine, cocoa, white chocolate control, exercise performance, sports nutrition, ergogenic aid, fatigue index, power output, heart rate, RPE, rate of perceived exertion, healthy adults, sprint timing, muscle fatigue, vasodilation, nitric oxide, athletic performance, supplementation, Nutrients journal

A 2025 systematic review published in the journal Nutrients analyzed the role of folate supplementation in managing peripheral neuropathy (PN). The review synthesized data from 12 studies, which included a total of 3015 patients. The findings demonstrated "promising symptomatic benefits". This included pain reductions reaching 3 points , symptom resolution rates as high as 87.5% , and improvements in Neuropathy Total Symptom Score (NTSS-6) scores ranging from 0.9 to 1.5 points.

Beyond symptoms, the review also highlighted objective structural improvements, such as increases in epidermal nerve fiber density (ENFD) that reached 97% in one case. Furthermore, folate supplementation was found to significantly decrease levels of homocysteine and high-sensitivity C-reactive protein (hs-CRP). The review concluded that folate has an "excellent safety profile," reporting only one adverse event among 1367 individuals.

• "This information is for educational purposes only and should not be interpreted as medical advice."

• "The study discussed is a systematic review, which synthesizes data from 12 other studies (including observational studies and randomized controlled trials). The included studies used various folate forms and dosages, often in combination with other B-vitamins."

• "Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications."

#Folate #PeripheralNeuropathy #DiabeticPeripheralNeuropathy #SystematicReview #Homocysteine

Alves Maues, A.C.; Moren Abat, M.G.; Benlloch, M.; Mariscal, G. Folate Supplementation for Peripheral Neuropathy: A Systematic Review. Nutrients 2025, 17, 3299. https://doi.org/10.3390/nu17203299

Folate, folic acid, peripheral neuropathy, diabetic peripheral neuropathy, systematic review, L-methylfolate, NTSS-6, epidermal nerve fiber density, ENFD, pain scores, homocysteine, hs-CRP, nerve regeneration, nerve health, Metanx, methylcobalamin, pyridoxal-5'-phosphate, PN, DPN, neuroprotection, vitamin B, myelin maintenance, symptom resolution, UMP, B12

A study in the journal Nutrients explored the effects of Lepidium meyenii Walpers (LMW), also known as Maca, on salivary gland damage caused by radiation in mice. Researchers found that mice treated with an LMW extract (LMWE) showed significant improvements compared to an untreated radiation-injury group. Specifically, LMWE treatment reduced the saliva secretion lag time from about 198 seconds in the injured group to as low as 159 seconds. Furthermore, the higher dose of LMWE increased salivary amylase activity by over 20% and helped restore the weight of the salivary glands. The study also identified two potentially new active compounds in Maca, DHPPD and E4Z-PD, which appeared to selectively promote the differentiation of specific types of salivary gland cells in a lab setting. These findings suggest that LMWE may help protect against and regenerate salivary gland dysfunction following radiation injury through its antioxidant and cell-differentiating properties.

This information is for educational purposes only and should not be interpreted as medical advice. The study discussed was conducted on animals and in vitro (lab) models. Further research is needed to confirm these findings in humans. Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.

#LepidiumMeyenii #Xerostomia #SalivaryGland #RadiationInjury #MacaRoot

Tsai, Y.-T.; Lin, Y.-C.; Cheng, M.-J.; Shih, C.-M.; Tsai, C.-S.; Lai, Z.-H.; Wu, C.-Y.; Liu, C.-W.; Lin, F.-Y.; Lin, Y.-W. Lepidium meyenii Walpers Promotes the Regeneration of Salivary Gland and Prevents Xerostomia After Irradiation Injury. Nutrients 2025, 17, 3033. https://doi.org/10.3390/nu17193033

Lepidium meyenii Walpers, maca, Peruvian ginseng, xerostomia, dry mouth, radiation therapy side effects, head and neck cancer, salivary gland regeneration, acinar atrophy, TGF-β1 pathway, Par-C10 cells, salivary organoid, amifostine, pilocarpine, radioprotection, antioxidant, anti-fibrotic, macamides, macaenes, DHPPD, E4Z-PD, salivary amylase, AQP5, Mist1

A recent 8-week, randomized, double-blind, placebo-controlled pilot study explored the effects of the probiotic strain Weizmannia coagulans BC99 on symptoms of anxiety and depression. The trial involved 79 participants who received either 3 grams of the BC99 probiotic, containing 5 billion CFUs, or a placebo daily. While both groups saw improvements, the BC99 group experienced a greater reduction in depression and anxiety scores (HAMD and HAMA scales) compared to the placebo group, though this difference was not statistically significant.

More significantly, the study found that BC99 supplementation led to several key biological changes. It helped regulate inflammatory cytokines, notably increasing the anti-inflammatory IL-10. Participants taking BC99 also showed a significant increase in the calming neurotransmitter gamma-aminobutyric acid (-GABA). Furthermore, the probiotic altered the gut microbiome by increasing the abundance of beneficial bacteria like Faecalibactrium, Megamonas, Dialister, and Agathobacter, while also boosting the production of beneficial short-chain fatty acids (SCFAs) like propionic and isobutyric acid. These findings suggest BC99 may alleviate symptoms of anxiety and depression by positively influencing the gut-brain axis.

3. Disclaimers

• This information is for educational purposes only and should not be interpreted as medical advice.

• The study discussed was a clinical pilot study conducted on human adults. Further research may be needed to confirm these findings.

• Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.

• This channel does not provide medical advice.

#WeizmanniaCoagulans #Probiotics #GutBrainAxis #AnxietyResearch #BC99

Tie S, Pan Y, Pang C, Saman A, Dong Y, Fang S, Zhu J, Wu Y, Gu S. The Impact of Weizmannia coagulans BC99 on Anxiety and Depression: An 8-Week Clinical Pilot Study Through the Gut Microbiota–Brain Axis. Nutrients. 2025; 17(19):3087. https://doi.org/10.3390/nu17193087

Alchepharma,Ralph Turchiano,citation,research,study,Weizmannia coagulans BC99,probiotics for anxiety,probiotics for depression,gut microbiota-brain axis,psychobiotics,Hamilton Depression Rating Scale,short-chain fatty acids,gamma-aminobutyric acid,inflammatory cytokines,gut dysbiosis,mental health supplements,Faecalibactrium,neurotransmitter regulation,gut health,microbiome and mood,clinical nutrition,bacterial therapy

The present study demonstrates that green tea extract and ginger supplementation, individually and in combination, enhanced endurance performance, metabolic efficiency, and thermal perception in recreationally active males under normothermic and cold conditions. Green tea alone increased time to exhaustion and reduced respiratory exchange ratio in normothermic conditions, indicating improved fat oxidation and endurance capacity. In cold conditions, the combination of green tea and ginger enhanced time to exhaustion, lowered the respiratory exchange ratio, improved thermal sensation, and reduced muscle soreness. These effects are most pronounced in cold environments, where the combined supplementation mitigated the heightened physiological demands of cold exposure while amplifying metabolic benefits. To our knowledge, this is the first randomized, double-blind crossover trial to systematically evaluate the supportive combined effects of green tea and ginger across different environmental conditions.

A 2025 study in the journal Nutrients investigated the effects of green tea extract and ginger on endurance performance in different temperatures. In a randomized, double-blind crossover trial, sixteen recreationally active males were tested under eight different conditions. The conditions included taking a placebo, 500 mg of green tea extract, 1000 mg of ginger, or a combination of both, each in normal (normothermic) and cold environments (

). In normal temperatures, both green tea alone and the combined supplement significantly increased the time-to-exhaustion (endurance) and reduced the respiratory exchange ratio (RER), indicating greater fat oxidation, compared to the placebo. In cold conditions, the combination of green tea and ginger was most effective, significantly enhancing endurance, improving thermal sensation (feeling warmer), and reducing RER compared to both placebo and ginger alone. All active supplements (green tea, ginger, and combined) also significantly decreased muscle soreness 24 hours after exercise in the cold compared to the placebo.

Disclaimers:

• "This information is for educational purposes only and should not be interpreted as medical advice."

• "The study discussed was conducted on a small sample of 16 recreationally active males. The findings cannot be extrapolated to women, older adults, or competitive athletes, and further research is needed."

• "Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications."

• "This channel is not monetized and does not provide medical advice."

• (Reminder: Please include a verbal disclaimer in the video itself.)

#GreenTea #Ginger #EndurancePerformance #ColdEnvironment #FatOxidation

Demirli, A.; Ulupınar, S.; Terzi, M.; Özbay, S.; Özkara, A.B.; Gençoğlu, C.; Ouergui, L; Ardigò, L.P. Synergistic Effects of Green Tea Extract and Ginger Supplementation on Endurance Performance and Thermal Perception in Normothermic and Cold Environments: A Randomized, Placebo-Controlled, Double-Blind Crossover Trial. Nutrients 2025, 17, 2949. https://doi.org/10.3390/nu17182949.

Alchepharma,Ralph Turchiano,citation,research,study,green tea extract,ginger supplementation,endurance performance,cold environment,normothermic,thermal perception,fat oxidation,time to exhaustion,perceived exertion,muscle soreness,synergistic effects,catechins,epigallocatechin gallate,gingerols,ergogenic aids,thermogenesis,randomized controlled trial,crossover trial,exercise physiology,submaximal exercise,VO2 max,sports nutritionNarrator: Ralph Turchiano, AlchePharma CEO

A major scientific review looked at the best available evidence on apple cider vinegar (ACV) and its effects on body weight. Researchers combined the results from 9 different studies that included adults who were overweight, obese, or had type 2 diabetes.

Here’s what they found:

• Taking ACV daily was linked to a significant drop in body weight, BMI, and waist size.

• The authors calculated this could amount to an average weight loss of about 7.4 kg (over 16 pounds).

• The most effective approach seemed to be taking about two tablespoons (30 mL) per day for up to 12 weeks.

The main takeaway is that science suggests ACV may be a helpful tool for short-term weight management.

Disclaimers:

"This information is for educational purposes only and should not be interpreted as medical advice."

"The study discussed is a meta-analysis of randomized controlled trials conducted on adult humans who were overweight, obese, or had type 2 diabetes. The intervention periods in the included studies were relatively short, ranging from 4 to 12 weeks."

"Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications."

"This channel does not provide medical advice."

#AppleCiderVinegar #WeightLoss #BodyComposition #MetaAnalysis #ObesityResearch

Source Article Citation:

Castagna, A.; Ferro, Y.; Noto, F.R.; et al. Effect of Apple Cider Vinegar Intake on Body Composition in Humans with Type 2 Diabetes and/or Overweight: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients 2025, 17, 3000. DOI: https://doi.org/10.3390/nu17183000

Apple cider vinegar, ACV, acetic acid, weight management, body composition, obesity, overweight, type 2 diabetes, meta-analysis, randomized controlled trial, RCT, body weight, BMI, body mass index, waist circumference, visceral adiposity, anthropometric measurements, weight loss, dietary supplement, short-term weight management, metabolic health, adiposity, nutritional intervention, systematic review, dose-response

A recent randomized, double-blind, placebo-controlled study published in the journal Nutrients investigated the effects of Cistanche deserticola (CD) supplementation on muscle strength and recovery. The eight-week trial involved 48 male participants, who were divided into resistance-trained and untrained groups. Participants in the intervention group received 5 g of CD extract twice daily, for a total of 10 g per day, while following a standardized resistance training program three times per week.

Among untrained individuals, the CD group showed significantly greater improvements in 1RM bench press, 1RM squat, maximal voluntary isometric contraction (MVIC), and repetitions to failure (RTF) compared to the placebo group. Furthermore, the CD group exhibited significantly improved recovery markers, including increased serum testosterone and decreased levels of cortisol, C-reactive protein (CRP), and creatine kinase (CK). In the trained group, CD supplementation led to significant increases in 1RM squat strength and MVIC. While upper body strength and endurance gains were not statistically different from the placebo group, the trained CD group still showed significantly better recovery markers, including improved testosterone and cortisol levels and marked reductions in CRP and CK. The authors concluded that eight weeks of CD supplementation effectively enhanced muscle strength and facilitated post-exercise recovery.

Disclaimers:

• "This information is for educational purposes only and should not be interpreted as medical advice."

• "The study discussed was conducted on healthy male participants (both resistance-trained and untrained). Further research may be needed to confirm these findings in other populations."

• "Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications."

• "This channel does not provide medical advice."

#CistancheDeserticola #MuscleStrength #ResistanceTraining #MuscleRecovery #SportsNutrition

Tao B, Lian W, Min R, Zhang X, Chen L, Hao S, Li Z, Ma C, Zhang H, Liu C. Effects of Cistanche deserticola Y.C. Ma Supplementation on Muscle Strength and Recovery: A Randomized Controlled Trial. Nutrients. 2025; 17(18):2965. https://doi.org/10.3390/nu17182965

Alchepharma,Ralph Turchiano,citation,research,study,Cistanche deserticola,Desert Ginseng,muscle strength,muscle recovery,resistance training,testosterone,cortisol,creatine kinase,C-reactive protein,randomized controlled trial,ergogenic aid,sports nutrition,phenylethanoid glycosides,echinacoside,acteoside,traditional Chinese medicine,strength gains,muscle endurance,post-exercise recovery,hormonal response,inflammation markers,1RM bench press,1RM squat

A new study in the journal Food Quality and Preference investigated if increasing the spiciness of a meal could influence eating behaviors and reduce how much food people consume. In a series of experiments, researchers had adults eat either a mild or a spicy version of beef chili or chicken tikka masala in a lab setting. The results were significant: when participants ate the spicy beef chili, they consumed 11% less food (about 46 grams) and ate 11% more slowly compared to when they ate the mild version. A similar outcome was observed with a reformulated chicken tikka masala, where the spicy version led to an 18% reduction in food intake (about 64 grams) and a 17% slower eating rate. Interestingly, this reduction in consumption was not because participants liked the spicy food less or drank more water. The findings suggest that the “oral burn” from capsaicin—the active component in chili peppers—directly leads to slower eating and bite rates, which in turn reduces overall food and energy intake.

Disclaimers

This information is for educational purposes only and should not be interpreted as medical advice.

The study discussed was conducted on adults in a controlled laboratory setting. These findings may not apply to different populations or real-world dining situations.

Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.

#Capsaicin #EatingRate #FoodIntake #Satiation #Paprika

Cunningham, P. M., Smith, I. M., & Hayes, J. E. (2025). Increasing the spiciness of a lunch meal influences oral processing behaviors and decreases food and energy intake. Food Quality and Preference, 131, 105566.

Capsaicin, paprika, oral burn, spice, chili pepper, eating rate, food intake, energy intake, oral processing, satiation, satiety, ad libitum intake, beef chili, chicken tikka masala, eating behavior, weight management, food formulation, paprika, non-textural manipulation, bite rate, meal duration, food pleasure, calorie reduction, appetite, human study, crossover design

A recent crossover randomized controlled trial published in the journal Nutrients investigated the effects of paprika xanthophylls (PX) on endurance and cognitive function in 21 healthy college students. Participants took a supplement containing 9 mg of PX daily for one month and were compared against a control condition (no intake). The study found significant improvements in physical endurance for the PX group, including higher exercise efficiency during both incremental (p=0.004) and constant load tests (p=0.030). Heart rate was also significantly lower during both the incremental test (p=0.032) and the constant load test (p=0.020). While there were no significant differences between the groups on cognitive tests, the PX group alone showed significant internal improvements in scores on the Trail Making Test Type B (p=0.034) and the Stroop test interference rate I (p=0.040). The authors speculate these benefits may be due to improved oxygen delivery efficiency.

Disclaimers:

"This information is for educational purposes only and should not be interpreted as medical advice."

"The study discussed was conducted on a small sample of healthy college students and was predominantly male (18 males, 3 females). The authors note the results should be interpreted with caution and may not be generalizable to other populations."

"This study did not use a placebo control group, which is a methodological limitation."

"Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications."

"This Channel does not provide medical advice."

#PaprikaXanthophyll #EndurancePerformance #CognitiveFunction #ExerciseEfficiency #OxygenDelivery

Kim D, Wadazumi T. Effects of Paprika Xanthophyll Intake on Endurance and Cognitive Function in College Students: A Crossover Randomized Controlled Trial. Nutrients. 2025; 17(17):2780. https://doi.org/10.3390/nu17172780

Alchepharma,Ralph Turchiano,citation,research,study,Paprika xanthophylls,capsanthin,capsorubin,endurance performance,cognitive function,exercise efficiency,oxygen delivery efficiency,DO2,red blood cell deformability,heart rate during exercise,college students,Stroop test,ventilatory threshold,antioxidant supplements,sports nutrition,ergogenic aids,brain oxygenation,executive function,neurocognitive function,microcirculation,athletic performance

A recent study in the journal GeroScience investigated how age-related declines in cellular energy, specifically the molecule Guanosine triphosphate (GTP), affect waste clearance in brain cells. Using hippocampal neurons from an Alzheimer's disease (AD) mouse model, researchers found a significant, age-dependent reduction in free GTP levels, which was accelerated in the AD model neurons. This energy deficit was shown to impair critical cellular processes like endocytosis and autophagy, leading to the accumulation of toxic amyloid-beta (Aß) aggregates and increased protein oxidation. Remarkably, the researchers then treated aged neurons for 24 hours with a combination of nicotinamide (a precursor to the energy-related molecule NAD+) and EGCG (a redox modulator found in green tea). This treatment was highly effective, restoring the depleted GTP levels in aged neurons all the way back to the normal, youthful levels seen in healthy, young neurons. This restoration of cellular energy enhanced the clearance of Aß aggregates and improved the viability of aged AD model neurons by 22%.

Disclaimers

• "This information is for educational purposes only and should not be interpreted as medical advice."

• "The study discussed was conducted in vitro on neurons isolated from mice. Further research is needed to confirm these findings in humans."

• "Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications."

• "This channel is not monetized and does not provide medical advice."

#GTP #Autophagy #AlzheimersResearch #Nicotinamide #EGCG

Source: Santana, R. A., McWhirt, J. M., & Brewer, G. J. (2025). Treatment of age-related decreases in GTP levels restores endocytosis and autophagy. GeroScience. https://doi.org/10.1007/s11357-025-01786-4

Guanosine triphosphate, GTP, Alzheimer's disease, neuronal aging, autophagy, endocytosis, bioenergetics, nicotinamide, EGCG, NAD+, Nrf2, 3xTg-AD mouse model, proteostasis, amyloid-beta clearance, Aß aggregates, mitochondrial dysfunction, cellular energy, redox state, Rab7, Arl8b, neuronal viability, protein oxidation, neurodegeneration, in vitro study, hippocampal neurons

A recent study in Advanced Healthcare Materials reports a novel method for regenerating tooth enamel using water-based films made from keratin, a protein abundant in sources like wool. Researchers found that these keratin films can self-assemble into organized scaffolds that guide the growth of aligned apatite nanocrystals, mimicking natural enamel formation. When applied to artificially created early enamel lesions (white spot lesions), the keratin-based system was able to repair the damage, restoring both the tooth's optical appearance and its mechanical properties. Notably, the mechanical recovery was significant; nanoindentation tests showed the elastic modulus of damaged enamel increased from ~5 GPa back to ~53 GPa, and hardness recovered from ~0.1 GPa to over 1.0 GPa after treatment. These findings present a promising, simple, and potentially low-cost strategy for the clinical treatment of early dental caries.

Disclaimers:

• This information is for educational purposes only and should not be interpreted as medical or dental advice.

• The study discussed was conducted in vitro (on extracted human teeth in a laboratory setting). Further research and human clinical trials are necessary to confirm these findings and evaluate safety and efficacy.

• Always consult with a qualified dental professional before making any changes to your oral healthcare routine or treatment plan.

• This channel does not provide medical advice.

#Keratin #EnamelRegeneration #Biomineralization #DentalResearch #RegenerativeDentistry

S. Gamea, E. Radvar, D. Athanasiadou, et al. “ Biomimetic Mineralization of Keratin Scaffolds for Enamel Regeneration.” Adv. Healthcare Mater. (2025): e02465. https://doi.org/10.1002/adhm.202502465

Alchepharma,Ralph Turchiano,citation,research,study,Keratin,enamel regeneration,biomimetic mineralization,apatite nanocrystals,hard tissue regeneration,dental caries,white spot lesion repair,protein scaffolds,self-assembly,spherulites,nanoindentation,Knoop microhardness,tooth decay treatment,regenerative dentistry,biomaterials,apatite nucleation,hierarchical structure,dental tissue engineering,keratin films,in vitro study,restorative dentistry,tooth repair

A study in the journal Nature has uncovered a significant link between the brain's natural lithium levels and Alzheimer's disease (AD). After analyzing 27 different metals in post-mortem human brain tissue, researchers found lithium was the only one significantly reduced in individuals with both mild cognitive impairment (MCI) and AD. The research also showed that amyloid-β plaques, a key marker of AD, trap lithium, which further lowers its availability for use by brain cells.

To confirm this link, scientists conducted experiments on mouse models. They found that reducing the brain's lithium levels by roughly 50% caused an acceleration of AD-like pathology, including increased amyloid-β and phospho-tau deposits, greater neuroinflammation, and a more rapid decline in cognitive function. These effects appear to be driven, at least in part, by the over-activity of a kinase known as GSK3β.

As a potential therapeutic strategy, the team tested a specific salt, lithium orotate (LiO), which is less likely to be sequestered by amyloid plaques. In AD mouse models, low-dose treatment with LiO successfully prevented memory loss and the accumulation of amyloid and tau pathology. The therapy was highly effective, reducing the Aβ plaque burden by about 70% in one model. Furthermore, LiO even reversed age-related memory decline in normal aging mice, pointing to a broader role for lithium in maintaining cognitive health. The findings suggest that a disruption of lithium balance may be a treatable early event in the development of Alzheimer's disease.

Disclaimers

"This information is for educational purposes only and should not be interpreted as medical advice."

"The study discussed was conducted on human post-mortem brain samples and mouse models. Further research may be needed to confirm these findings in human clinical trials."

"Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications. Lithium can be toxic at high doses and should only be used under medical supervision."

"This channel does not provide medical advice."

#Lithium #AlzheimersDisease #NeuroscienceResearch #CognitiveHealth #LithiumOrotate

Aron, L., Ngian, Z.K., Qiu, C., et al. "Lithium deficiency and the onset of Alzheimer's disease." Nature (2025).

A recent network meta-analysis published in the journal

Nutrients systematically compared the effectiveness of seven common nutritional supplements for treating knee osteoarthritis (KOA). The analysis included 39 randomized controlled trials (RCTs) with a total of 4,599 patients. Researchers evaluated the impact of eggshell membrane, vitamin D, Boswellia, curcumin, ginger, krill oil, and collagen against a placebo for improving pain, stiffness, and function. The results showed that compared to a placebo, Boswellia provided statistically significant improvements across all measures, including WOMAC pain (mean difference [MD] = -10.58), stiffness (MD = -9.47), function (MD = -14.00), and VAS pain (MD = -17.26). Bayesian analysis consistently ranked Boswellia as the most likely to be the best option for pain and stiffness relief. Other supplements also showed benefits; krill oil, curcumin, and collagen significantly improved function, while collagen, curcumin, and ginger significantly reduced VAS pain scores. Importantly, no supplement was associated with an increase in adverse events compared to the placebo. The authors conclude that certain supplements, particularly Boswellia, appear to be effective and well-tolerated for managing KOA symptoms.

Disclaimers:

• "This information is for educational purposes only and should not be interpreted as medical advice."

• "The study discussed is a network meta-analysis of randomized controlled trials conducted on humans. Further research may be needed to confirm these findings."

• "Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications."

#Boswellia #Curcumin #Collagen #KrillOil #Ginger

Zhang Y, Gui Y, Adams R, Farragher J, Itsiopoulos C, Bow K, Cai M, Han J. Comparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis. Nutrients. 2025; 17(15):2547. https://doi.org/10.3390/nu17152547

Alchepharma,Ralph Turchiano,citation,research,study,Knee osteoarthritis,nutritional supplements,Boswellia,curcumin,collagen,ginger,krill oil,eggshell membrane,vitamin D,network meta-analysis,randomized controlled trials,WOMAC pain,WOMAC stiffness,WOMAC function,VAS pain,joint pain relief,osteoarthritis treatment,supplement efficacy,anti-inflammatory supplements

A recent study published in Frontiers in Psychology surveyed 1,082 participants to investigate how food influences sleep and dreams, exploring direct food effects, physiological symptoms (food distress), and altered sleep quality. The study found that 40.2% of participants reported food affecting their sleep, with 24.7% claiming it worsened sleep and 20.1% reporting improvement. Furthermore, 5.5% of participants experienced food-dependent dreaming. The perceived effect of food on dreams was linked to higher nightmare recall and Nightmare Disorder Index scores. Desserts/sweets (31%) and dairy (22%) were most frequently blamed for disturbing dream changes. The study also revealed associations between perceived food-dependent dreaming and food allergies and gluten intolerance, while worse sleep perceptions were tied to lactose intolerance. Importantly, higher Nightmare Disorder Index scores were strongly associated with food allergy and lactose intolerance, with the latter being mediated by the severity of gastrointestinal symptoms. Healthy eating, such as less evening eating, predicted higher dream recall, while unhealthy eating, including gastric symptoms, lower reliance on hunger/satiety cues, and evening eating, predicted nightmares and dream negativity. These findings suggest that food sensitivities, particularly lactose intolerance, can contribute to nightmare prevalence, potentially through gastrointestinal symptoms, opening new avenues for research on food-dependent dreaming and non-pharmacological interventions for sleep disturbances.

Disclaimers:

"This information is for educational purposes only and should not be interpreted as medical advice." "The study discussed was conducted on humans via an online survey and focuses on perceived effects and associations. Further experimental research is needed to confirm direct causal links between specific foods and dream content." "Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications." "This channel is not monetized and does not provide medical advice

#FoodAndDreams #NightmareResearch #LactoseIntolerance #SleepHealth #DietAndSleep

Nielsen T, Radke J, Picard-Deland C and Powell RA (2025) More dreams of the rarebit fiend: food sensitivity and dietary correlates of sleep and dreaming. Front. Psychol. 16:1544475. doi: 10.3389/fpsyg.2025.1544475

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A recent randomized, placebo-controlled, crossover trial investigated the link between high-dose oral thiamine supplementation and chronic fatigue in 40 patients with quiescent inflammatory bowel disease (qIBD). The study found that while high-dose thiamine (600-1800 mg/day for 4 weeks) significantly reduced fatigue, it did not alter the overall gut microbiota composition or short-chain fatty acid (SCFA) concentrations.

Instead, the study revealed a significant correlation: patients with higher baseline levels of the gut bacteria Faecalibacterium prausnitzii and Roseburia hominis were more likely to respond positively to thiamine treatment. Specifically, Faecalibacterium prausnitzii was more abundant in thiamine responders both before (P=.019) and after (P=.038) treatment. The relative abundance of both Faecalibacterium prausnitzii and Roseburia hominis inversely correlated with improvements in IBD fatigue scores. Of the patients classified as responders (those who decreased their IBD-FQ1 score by 3 or more points), all 17 individuals showed this positive response. Furthermore, Faecalibacterium prausnitzii abundance was significantly greater in these responders compared to nonresponders. These findings suggest that these specific bacteria may serve as markers to predict who will benefit from thiamine for IBD-related fatigue, rather than being directly modified by the thiamine itself.

3. Disclaimers:

"This information is for educational purposes only and should not be interpreted as medical advice." "The study discussed was conducted on a specific population (patients with quiescent inflammatory bowel disease). Further research may be needed to confirm these findings in other populations." "Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications." "This channel is not monetized and does not provide medical advice."

#IBDFatigue #Thiamine #IBD #FaecalibacteriumPrausnitzii #InflammatoryBowelDisease

Thiamine-Reduced Fatigue in Quiescent Inflammatory Bowel Disease Is Linked to Faecalibacterium prausnitzii Abundance Bermúdez-Sánchez, Sandra et al. Gastro Hep Advances, Volume 4, Issue 1, 100533

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Vitamin A5 is a fascinating "new" vitamin that acts as a vital key in your body. It helps activate something called the Retinoid X Receptor (RXR), which is like a central control panel or "master switch" for many important functions. This crucial vitamin comes from certain foods, especially leafy green vegetables. Research suggests that many people in Western countries aren't consuming enough of these foods, leading to a potential Vitamin A5 deficiency. This lack could be a contributing factor to the rising rates of poor mental health and neurological issues. By making sure you get enough Vitamin A5 through your diet, you're essentially providing your body with the right tool to keep these vital systems running smoothly, offering a plausible explanation for why a diet rich in vegetables is so protective against many common diseases.

Disclaimers

"This video shares information for learning only and isn't medical advice." "The science on Vitamin A5 is still growing, and we need more studies in people to fully understand all its effects, especially on the brain."

"Always talk to your doctor or a health expert before changing your diet or taking any new supplements, especially if you have health concerns or take medications." "This channel does not make money from videos and does not give medical advice."

#VitaminA5 #BrainHealth #HealthyEating #MentalWellness #EatYourGreens

Bohn T, Rohn S, Böhm V, Despotovic M, de Lera AR, Krezel W, Kucuk O, Bánáti D, Rühl R. Vitamin A5: Evidence, Definitions, Gaps, and Future Directions. Nutrients. 2025; 17(14):2317. https://doi.org/10.3390/nu17142317

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A randomized, double-blind, placebo-controlled trial investigated the sleep-promoting effects of Heukharang lettuce (Lactuca sativa L.) extract in Korean adults aged 30-65 with poor sleep quality (Pittsburgh Sleep Quality Index (PSQI) score > 5). Over four weeks, participants received two capsules daily of either the test extract or a placebo. The study found that the test group showed a greater improvement in global PSQI scores compared to the placebo group (6.48 ± 0.63 vs. 7.41 ± 0.57, p=0.0462). Objective measurements from actigraphy revealed significant improvements in total sleep time (TST) (421.68 ± 13.29 min vs. 386.57 ± 12.27 min, p=0.0023) and sleep efficiency (SE) (83.90 ± 1.60% vs. 81.01 ± 1.50%, p=0.0342) in the test group. Polysomnography (PSG) results also favored the test group, demonstrating higher TST (358.90 ± 19.75 min vs. 322.11 ± 17.66 min, p=0.0457), higher SE (86.86 ± 3.31% vs. 79.60 ± 2.99%, p=0.0182), and lower wake after sleep onset (WASO) (39.26 ± 10.57 min vs. 68.15 ± 9.60 min, p=0.0042). These findings suggest that Heukharang extract can enhance both sleep quality and quantity and is considered safe, indicating its potential as a functional food for improving sleep.

3. Disclaimers:

• This information is for educational purposes only and should not be interpreted as medical advice.

• The study discussed was conducted on Korean adults aged 30-65 with poor sleep quality. Further research may be needed to confirm these findings in other populations.

• Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.

• This channel is not monetized and does not provide medical advice.

• (Remember to include a verbal disclaimer in the video itself.)

#LettuceSleep #HeukharangExtract #SleepQualityImprovement #SleepResearch #FunctionalFood

Son K, Lee M, Bok MK, Hwang KJ, Lim H. Sleep Promoting Effects of Lettuce (Lactuca sativa L.) Extracts in Korean Adults with Poor Sleep Quality: A Randomized, Double-Blind Placebo-Controlled Trial. Nutrients. 2025; 17(13):2172. https://doi.org/10.3390/nu17132172

Alchepharma,Ralph Turchiano,citation,research,study,Pittsburgh Sleep Quality Index (PSQI),total sleep time (TST),sleep efficiency (SE),wake after sleep onset (WASO),Heukharang extract efficacy,sleep disorder natural remedies,sesquiterpene lactones (BSLs),lactucin sleep,lactucopicrin sleep,GABA receptors sleep,subjective sleep quality assessment,objective sleep measures,Korean adults health,sleep duration improvement,non-pharmacological sleep aids

A recent study published in LabMed Discovery investigated the effectiveness of a vitamin D3-loaded nanoemulsion in improving core manifestations of autism spectrum disorder (ASD) in children, compared to a widely available vitamin D3 product. The research involved 80 children with ASD, aged 3 to 6 years, divided into two groups over six months. Group I received an oral vitamin D3-loaded nanoemulsion, while Group II received a marketed oral vitamin D3 product.

Results showed that supplementation with the vitamin D3-loaded nanoemulsion in Group I led to significant elevations in both 25(OH) and 1,25(OH)2 forms of vitamin D3 (P < 0.0001). This group also experienced behavioral improvements, including a reduction in ASD severity (P = 0.0002), an increase in social IQ (P = 0.04), and a rise in total language age (P = 0.0009). In contrast, Group II, receiving the marketed vitamin D3 product, did not show significant adaptive behavioral improvements, despite elevated vitamin D3 levels. The study concludes that the vitamin D3-loaded nanoemulsion offered superior bioavailability and a tangible positive influence on ASD severity, adaptive behavior, fine motor abilities, and language performance.

3. Disclaimers:

"This information is for educational purposes only and should not be interpreted as medical advice."

"The study discussed was conducted on human participants (children with ASD). While promising, further research may be needed to confirm these findings across broader populations."

"Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications."

"This channel does not provide medical advice."

#AutismResearch #VitaminD3Nanoemulsion #ASDTreatment #Neurodevelopment #ChildhoodAutism

Study Citation:

Meguid, N. A., et al. (2025). Improved core manifestations of autism following supplementation with vitamin D3-loaded nanoemulsion. LabMed Discovery. doi.org/10.1016/j.lmd.2025.100071.

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