This episode takes a deep dive into the mitochondria, electron transport chain, how we get carbohydrates from our cells into the mitochondria and some fascinating genes that impact energy and longevity.

Studies Referenced:

On Mitochondria:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290976/#:~:text=Mitochondria%20are%20subcellular%20organelles%20evolved,cell%20life%20and%20cell%20death.

Electron Transport chain:

https://www.ncbi.nlm.nih.gov/books/NBK9885/#:~:text=In%20complex%20IV%2C%20two%20protons,each%20of%20these%20three%20complexes.

PDH, PDK and Aerobic Training:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665109

PDH/PDC Cofactors:

https://www.sciencedirect.com/topics/neuroscience/pyruvate-dehydrogenase-phosphatase#:~:text=The%20PDH%20multienzyme%20complex%20is,phosphorylation%20catalyzed%20by%20PDH%20kinase

Thiamine and PDH:

https://www.nature.com/articles/pr197371.pdf

PDH and Chronic Fatigue:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161229/

Thiamine and Endurance Training:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241913/#:~:text=To%20sum%20up%20the%20previous,similar%20benefits%20as%20endurance%20training

CoQ10 Biosynthesis Genes:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731490/

Organs with highest CoQ10 Concentrations:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178961/#:~:text=CoQ10%20is%20found%20throughout%20the,mg%20and%20decreases%20with%20age

Dietary Sources of CoQ10:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953254/

Anti-inflammatory mechanisms of CoQ10:

https://pubmed.ncbi.nlm.nih.gov/29421772/)

Effects of Acute CoQ10 Supplementation on Athletic Performance:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315638/#:~:text=For%20example%2C%20several%20studies%20have,individuals%20%5B12%2D14%5D

CoQ10 and German Athlete Power Study:

https://jissn.biomedcentral.com/articles/10.1186/1550-2783-10-24

Sirtuin Function:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514220/#:~:text=Sirtuins%20play%20a%20vital%20role,oxidative%20stress%20and%20energy%20metabolism

Sirtuins as Regulators of Healthspan:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872805/#:~:text=As%20a%20consequence%2C%20sirtuins%20regulate,and%20as%20such%20determines%20healthspan

SIRT3 and Fasting:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563434/

SIRT1 Overexpression and Metabolic Dysfunction:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222897/