On episode 20 of Creating Geneius, I share my full story of how I healed myself from mold toxicity and lyme disease. I share how conventional treatments didn't work for me, how my system became so sensitive I could barely tolerate food and what I did to overcome that. I go in depth into the three modalities that had an outsized impact on my ability to heal and the different challenges I faced as I became healthier.
This episode is a more in-depth look take on an article I wrote for the magazine Natural Nutmeg, which you can find at https://naturalnutmeg.com/ The magazine is an amazing resource for helping connect people with the practitioners they need, and is a great source of information about all things health and wellness. I highly recommend you check it out!
As always: for more details about my coaching and where to reach out if you are interested, my instagram is jappleton15 or you can send me an email to jacob@creatingeneius.com
Summary
In this episode, Jacob Appleton discusses the illusion of permanence and how it impacts our lives. He shares his experience at a meditation retreat where he learned to let go of attachments and allow experiences to flow. Jacob emphasizes that nothing is permanent, not even physical structures, and that understanding this can help us see through illusions and appreciate the beauty of impermanence. He also explores the importance of fully feeling and embracing emotions, knowing that they are transient and will pass. Jacob shares personal stories and highlights the benefits of detachment and practicing elevated emotions.
Keywords
illusion of permanence, impermanence, letting go, meditation retreat, emotions, detachment, elevated emotions
Takeaways
The idea of permanence is an illusion that impacts the way we function in the world.
Understanding the transient nature of everything can help us see through illusions and appreciate the beauty of impermanence.
Fully feeling and embracing emotions, knowing that they are transient, can help us navigate through them and release suffering.
Detachment from expectations and attachments allows us to go deeper into our experiences and feel a greater range of emotions.
Practicing elevated emotions can help us chip away at trapped emotional energy and create space for both love and pain.
Summary
In this episode, I discuss the overwhelming amount of information on different diets and the lack of bio-individuality in studies. He highlights the extreme claims on social media and the lack of nuance in diet discussions. I emphasize the importance of understanding genetics and how they impact our ability to handle toxins in food. I specifically discuss the role of oxalic acid and how genetic variants can affect our ability to break it down. I also share an experience with adjusting my diet based on how I felt after eating and the importance of starting with whole foods and cooking from home.
Keywords
diets, bio-individuality, social media, genetics, oxalic acid, whole foods, cooking from home, individualized approach
Takeaways
There is an overwhelming amount of information on different diets, making it difficult to determine what to eat.
Many studies on diets are not done in a bio-individual way, leading to a lack of personalized recommendations.
Social media often promotes extreme and misleading claims about diets, lacking nuance and individuality.
Understanding genetics is important in determining how our bodies handle toxins in food.
Starting with whole foods and cooking from home is a solid foundation for a healthy diet.
Adjusting our diet based on how we feel after eating can help us find what works best for our bodies.
Summary
In this episode, I discuss the concept of resilience and its importance in overcoming difficulties. I share personal experiences of resilience in dealing with illness, studying for the MCAT, and building my business. Resilience is tested in various aspects of life, including physical health, emotional well-being, and interpersonal relationships. I provide two simple tactics to improve brain resilience: avoiding inflammatory omega-6 seed oils and practicing meditation.
At the end of the Episode, I also introduce the Genius Health Program, a coaching program that combines science, spirituality, and personalized approaches to help individuals achieve their health goals.
For more information on this: DM me on instagram @jappleton15
Keywords
resilience, difficulties, toughness, illness, MCAT, med school, chronic illness, physical resilience, emotional resilience, brain resilience, diet, seed oils, linoleic acid, inflammation, meditation, brain waves, kaleidoscopes, awe, coaching program, Genius Health Program
Takeaways
Resilience is the capacity to withstand or recover quickly from difficulties.
Resilience is tested in various aspects of life, including physical health, emotional well-being, and interpersonal relationships.
Avoiding inflammatory omega-6 seed oils can improve brain resilience.
Practicing meditation can help calm the mind, change brain waves, and build resilience.
The Genius Health Program combines science, spirituality, and personalized approaches to help individuals achieve their health goals.
Studies Mentioned:
"Relationship of Plasma Polyunsaturated Fatty Acids to Circulating Inflammatory Markers": https://academic.oup.com/jcem/article/91/2/439/2843288?login=false
"Increasing dietary linoleic acid does not increase tissue arachidonic acid content in adults consuming Western-type diets: a systematic review": https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-8-36
"α-Linolenate reduces the dietary requirement for linoleate in the growing rat" https://pubmed.ncbi.nlm.nih.gov/21880475/
"Effects of Increase in Amplitude of Occipital Alpha & Theta Brain Waves on Global Functioning Level of Patients with GAD" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741268/
Summary
Brett Kennedy, founder of Quantum Apparel, joins Creating Geneius and shares his journey of starting a clothing company with the goal of helping people raise their vibration through what they wear. The idea for Quantum Apparel came to him during a retreat in Mexico, where he saw t-shirts with uplifting messages and realized there was a market for clothing dedicated to the spiritual community. The clothing is designed to have a higher vibrational level and is meant to serve as a visual cue to help people feel good and raise their vibrations. Brett emphasizes the importance of finding communities and outsourcing tasks to experts to ensure the success of the business. He also discusses the connection between his spiritual journey and the clothing brand, as both are focused on personal growth and spreading positivity. The conversation explores the importance of intention and alignment in personal growth and habit formation. It delves into the transformative power of experiences, such as Bret's trip to Peru, and the awe-inspiring impact of ancient wonders. The role of music in Bret's life is also discussed, highlighting its influence and the joy it brings. The conversation emphasizes the need to align actions with one's true self and the importance of not pursuing experiences for the wrong reasons.
Keywords
Quantum Apparel, clothing, vibration, spiritual community, uplifting messages, higher vibrational level, visual cue, personal growth, positivity, intention, alignment, personal growth, habit formation, transformative experiences, awe-inspiring, ancient wonders, music, joy, music, passion, piano, guitar, career, taste, spiritual journey, movies, Ayahuasca, outcomes, presence
You can find Bret @quantumapparel7 on instagram and quantum-apparel.com to check out the quantum apparel shop!
Summary:
Gene Gresh, a compounding pharmacist and functional medicine practitioner joins the show to discuss the importance of personalized care in healthcare. He emphasizes the limitations of the one-size-fits-all model and the benefits of customizing treatments based on individual needs. Gene explains how compounding allows for the customization of medications and supplements, and how testing can help identify deficiencies and imbalances in the body. He also highlights the role of inflammation, oxidative stress, and immune dysregulation in chronic diseases, and the importance of addressing these factors in personalized care. Gene and I also discuss the connection between functional medicine and spirituality, and the potential for accessing greater states of consciousness through alignment and meditation. In this conversation, we discuss the importance of embracing the unknown and the role of curiosity in science. We also explore the connection between science and spirituality, highlighting the excitement of discovery and the impact of epigenetics on gene expression. The conversation also delves into the value of genetic testing in personalized medicine, emphasizing the significance of nutrient metabolism and the potential for optimizing health based on individual genetics. Gene shares his experiences in functional medicine and the evolving field, as well as his vision for the future of healthcare.
Keywords
compounding, personalized care, functional medicine, customization, testing, inflammation, oxidative stress, immune dysregulation, chronic diseases, environment, micronutrient test, nutrient deficiencies, energy, spirituality, alignment, meditation, unknown, curiosity, science, spirituality, epigenetics, gene expression, genetic testing, personalized medicine, nutrient metabolism, functional medicine, conventional medical model, comprehensive approach, limitations, future of healthcare
Takeaways
Personalized care is crucial in healthcare, as the one-size-fits-all model has limitations.
Compounding allows for the customization of medications and supplements based on individual needs.
Testing can help identify deficiencies, imbalances, and food sensitivities in the body.
Inflammation, oxidative stress, and immune dysregulation play a role in chronic diseases and should be addressed in personalized care.
The environment and nutrient quality of food are important factors in health and should be considered in personalized care.
The connection between functional medicine and spirituality opens up possibilities for accessing greater states of consciousness and living in alignment. Embracing the unknown and maintaining curiosity are essential for scientific exploration and discovery.
Epigenetics plays a crucial role in gene expression and can be influenced by environmental factors.
Genetic testing provides valuable insights into nutrient metabolism and can guide personalized approaches to healthcare.
The conventional medical model has limitations and a more comprehensive and personalized approach is needed.
Functional medicine is growing in popularity, but obstacles in the healthcare system and industry remain.
Raising consciousness and being open to new information are important for personal growth and understanding.
Collaboration and the integration of expertise from various fields are key to advancing functional medicine.
The future of healthcare lies in a more personalized and holistic approach that focuses on optimizing health and longevity.
Summary
In this conversation, Jacob interviews Ethan Aguilar, who shares his experience of blending meditation and deep self-work with being in a fraternity. Ethan discusses how he got into meditation and spirituality while in college, particularly during the COVID lockdowns. He talks about attending Dr. Joe Dispenza's events and how it helped him navigate the challenges of being in a fraternity. Ethan also shares how he maintained coherence and a higher frequency throughout his college experience, which had a positive impact on his academic performance and relationships. In this part of the conversation, Ethan and Jacob discuss the importance of gratitude and the power of internal emotions. They explore the idea of practicing elevated emotions and the challenges of feeling positive emotions compared to negative ones. They also discuss the integration of spiritual experiences and the role of physical activity in maintaining a healthy body. Ethan shares a story about using breathwork to sober up when he was drunk. In this final part of the conversation, Ethan and Jacob discuss the benefits of graduating early, the importance of setting boundaries, and the integration of spirituality into different aspects of life. They also touch on the idea of comparing oneself to others and the significance of individual experiences. Ethan shares his plans for his career in finance and how he intends to incorporate his spiritual practice into his work.
Keywords
meditation, spirituality, fraternity, college, COVID lockdowns, Dr. Joe Dispenza, coherence, frequency, gratitude, internal emotions, elevated emotions, integration, physical activity, breathwork, sobriety, graduating early, setting boundaries, spirituality, comparing oneself, individual experiences, career in finance
Takeaways
Blending meditation and deep self-work with being in a fraternity is possible and can be a transformative experience.
Maintaining coherence and a higher frequency throughout the day can have a positive impact on academic performance and relationships.
Getting comfortable with the unknown and embracing uncertainty can lead to personal growth and new opportunities.
Practicing meditation and maintaining a coherent state can help navigate challenging situations and reduce stress. Practicing gratitude and elevated emotions can help improve mental well-being.
It is important to integrate spiritual experiences into daily life through journaling and reflection.
Physical activity is essential for maintaining a healthy body and mind.
Breathwork can be a powerful tool for managing emotions and achieving sobriety. Graduating early can provide financial savings and the freedom to explore different opportunities.
Setting boundaries is crucial for maintaining balance and aligning with one's own values.
Integrating spirituality into different aspects of life can enhance decision-making and performance.
Comparing oneself to others is not productive; focusing on personal growth and improvement is more important.
Individual experiences and perspectives are unique and should be valued.
Incorporating spirituality into a career in finance can lead to ethical leadership and enhanced performance.
Summary
In this episode, Jacob Appleton discusses the creative process and the importance of surrendering to it. He shares his experience with meditation and how he initially struggled with it but eventually found his own way. Jacob emphasizes the value of throwing oneself into new experiences and not getting married to a specific idea or vision. He talks about the importance of recognizing inauthenticity and being willing to let go of ideas that don't feel right. Overall, the episode explores the growth and learning that comes from trying new things and being open to change.
Takeaways
The creative process requires surrendering to whatever comes to mind and allowing oneself to create freely.
Trying new things and throwing oneself into new experiences can be valuable for personal growth.
Recognizing inauthenticity and being willing to let go of ideas that don't feel right is important for creative expression.
Progress and magic happen when we learn and grow from each experience.
The value of catching oneself earlier in the creative process and making adjustments.
Not getting married to a specific idea or vision and being open to change.
Authenticity is more important than trying to fit an idea into a preconceived box.
The creative process is not a reflection of one's identity as a creator.
Being open to change and trying different approaches can lead to better outcomes.
The importance of recognizing the lessons and messages that come from challenges and problems.
Summary
In this episode, Jacob Appleton interviews Abri Turner, a musician and creator of the alter ego Blue Like Fire. They discuss the inspiration behind Blue Like Fire and its meaning of breaking free from labels and perceptions. Abri shares her journey of overcoming anxiety and depression and how music has been a healing outlet for her. They also talk about surrendering to the unknown and the importance of having fun and being less structured in creative endeavors. Abri explains the concept of the four torches, which represent different aspects of her alter ego, and the significance of each component. In this conversation, Abri Turner shares her experience with implementing probiotics and the surprising outcome of increased energy. They also discuss the connection between creativity and different energy centers, as well as the benefits of meditation and the transformative effects of a retreat. Abri offers advice for beginners in meditation and encourages creative flow without forcing ideas into a predetermined box. She also shares her upcoming projects and collaborations.
Takeaways
Blue Like Fire represents breaking free from labels and perceptions
Music is a healing outlet for emotions and can be used to self-regulate
Surrendering to the unknown can lead to transformation and growth
Having fun and being less structured can enhance creativity
The four torches concept represents different aspects of the alter ego Implementing probiotics can have surprising benefits, such as increased energy.
Creativity is connected to different energy centers, and expressing oneself through art and music can be a high expression of these centers.
Meditation can lead to profound experiences and the release of energetic blockages.
Life is a practice, and patterns will continue to show up until they are resolved.
Meditation is a valuable tool for practicing who you want to be and creating a sense of peace.
Allowing creativity to flow without forcing it into a predetermined box can lead to more authentic and successful outcomes.
Building a network of collaborators is important for bringing creative ideas to life.
Celebrating milestones, no matter how small, is important for motivation and growth.
Titles
The Four Torches: Symbolism in the Alter Ego
Breaking Free: The Inspiration Behind Blue Like Fire Upcoming Projects and Collaborations
Creativity and the Connection to Energy Centers
Chapters
00:00 Introduction and Inspiration
07:09 The Healing Power of Music
18:41 The Portrayal of Surrender in "The Killer" and "Shark Cage"
27:53 Meditation for Integration
33:54 The Four Torches: What are they?
39:26 Implementing Health Practices and Creativity
48:54 Transformative Retreat Experiences
56:57 Allowing Ideas to Flow Naturally
01:04:18 Conclusion and Future Plans
Summary
In this episode, Jacob Appleton discusses the importance of integrating information and experiences in order to improve health and life. He shares his personal journey of getting sick and how he used integration to overcome his challenges. Jacob emphasizes the connection between the mind, body, and spirit, and how they all impact our physical well-being. He highlights the role of journaling, exercise, and meditation in the integration process. Jacob also talks about the power of gratitude and the importance of being authentic in expressing it. He concludes by introducing his new venture, integration coaching, aimed at helping others integrate their breakthroughs and create positive change in their lives.
If this form of coaching sounds interesting, you can contact Jacob on instagram @jappleton15, or by email at jacobappleton15@gmail.com
Keywords
integration, health, mind-body connection, journaling, exercise, meditation, gratitude, authenticity, breakthroughs, integration coaching
Takeaways
Integration is the key to taking breakthroughs and implementing them into our lives to improve our health and well-being.
The mind, body, and spirit are interconnected, and addressing all three is essential for optimal health.
Journaling is a powerful tool for clearing the mind, creating space for new information, and integrating breakthroughs.
Exercise and movement help release emotions, clear out old patterns, and create an environment for new information to be integrated.
Gratitude is important, but it's crucial to genuinely feel and express gratitude for it to have a positive impact.
Meditation allows for introspection, awareness of patterns, and conscious decision-making, leading to integration and personal growth.
Integration starts before the breakthrough, with learning, preparation, and understanding of what needs to be done.
Integration coaching is a new venture aimed at helping others integrate their breakthroughs and create positive change in their lives.
Chapters
00:00 Introduction
06:26 Journaling
10:47 Integration Using Exercise
18:33 Changing Environment to Change Behavior
21:19 Gratitude Practice and Authenticity
24:46 Meditation
28:10 Themes Between Journaling, Exercise and Meditation
31:08 Difficult Beach Meditation and Little Wins
35:19 Building The Model: The integration Starts Before the Breakthrough
37:16 Deciding to Be Healthy
43:51 Integration Coaching
Summary
In this conversation, I explore the relationship between science and spirituality, focusing on the concept of energy centers or chakras. I explain that these centers, located in different parts of the body, are connected to nerves and play a role in how we relate to the world. I discuss the scientific basis for these centers and how they can become out of balance, leading to physical and emotional issues. I also highlight the importance of gene expression and lifestyle choices in influencing our spiritual expression and overall health.
Takeaways
Science and spirituality are interconnected, with science demystifying the mystical aspects of spirituality.
Energy centers or chakras are located in different parts of the body and play a role in how we relate to the world.
These centers have a scientific basis, as they are connected to nerves and can become out of balance, leading to physical and emotional issues.
Gene expression and lifestyle choices impact our spiritual expression and overall health.
Sound Bites
"Science is the language we use to demystify the mystical."
"There is a scientific reason for why energy centers or chakras exist in specific areas of the body."
"When energy centers are in alignment, we express ourselves in the highest ways."
Chapters
00:00 Introduction and Reflections on Travel Experiences
05:01 The Scientific Basis of Energy Centers
10:15 Energy Center #1
11:28 Energy Center #2
14:17 Energy Center #3
16:02 Energy Center #4
18:09 Energy Center #5
20:45 Energy Center #6
24:13 Energy Center #7
27:08 Energy Center #8
28:47 Why Are These Important?
In this episode, I discuss the importance of electrolytes for overall health and well-being. I explains how electrolytes, such as sodium, potassium, magnesium, and calcium, play a vital role in various bodily functions, including nerve signaling, muscle contraction, and hormonal regulation. I also highlight the impact of stress on electrolyte balance and the benefits of supplementing with sodium and magnesium. I provide recommendations for timing and sources of electrolyte intake, emphasizing the importance of hydration during exercise and the role of electrolytes in promoting better sleep. Overall, this episode offers valuable insights into the significance of electrolytes for optimal health.
https://my.clevelandclinic.org/health/diagnostics/21790-electrolytes
How Much Water Are We:
Secondary Adrenal Insufficiency: An Overlooked Cause of Hyponatremia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330026/
Plasma Adrenal Hormones in Magnesium Deficiency
https://pubmed.ncbi.nlm.nih.gov/3772520/
Long‐term magnesium supplementation improves glucocorticoid metabolism: A post‐hoc analysis of an intervention trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821302/
Where Is Potassium Usually Located:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716641/
Potassium and Nerve Excitability in Rats:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381316/
Calcium Intake and Stress:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877188/
How Much Water in Stress:
Effect of Magnesium on Sleep:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703169/
Dietary Sources of Potassium:
Mag Malate Benefits:
Calcium Rich Foods:
https://www.healthline.com/nutrition/15-calcium-rich-foods#TOC_TITLE_HDR_16
In this episode, I explore the impacts that our microbiome has on mental health. There are a few common environmental factors that almost all of us are exposed to daily that can disrupt our microbiome. After diving into those, I share some strategies we can all use to help balance our microbiome and take care of the bacteria in it, so that it will take care of us.
References:
Vitamin K and Microbiome:
The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health
Antibiotics and Mental Health: The Good, Bad and Ugly
Norepinephrine Function in the Body:
https://my.clevelandclinic.org/health/articles/22610-norepinephrine-noradrenaline
Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders:
Glyphosate, Microbiome and Mental Health:
Health Effects and Sources for Prebiotic Fibers:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041804/
Benefits of Spore-Based Probiotics:
https://coe.unt.edu/news/unt-research-shows-benefits-spore-based-probiotic-supplements
Probiotic Strains that are Good for the Brain:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053794/
Dietary Polyphenols and Gut Health:
In this episode, I explore what caffeine is and how it impacts our bodies. I look for some genetic factors that could play a role in caffeine-induced anxiety, genes that have a role in breaking down caffeine and some inflammation causing downsides of coffee. The latter portion of the episode evaluates some ways that we can modify our coffee to work with our genes rather than against them.
References:
General info on Caffeine:
pH Impact on Caffeine Breakdown:
Case Study: The Missing Link: A Case of Severe Adverse Reaction to Histamine in Food and Beverages
https://ncbi.nlm.nih.gov/pmc/articles/PMC8908729/
Link Between Histamine Intolerance and Anxiety:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563864/
Glutamate Levels and Working Memory:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605555/
Predicting learning and achievement using GABA and glutamate concentrations in human development
”https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001325
Study on Activated Charcoal's Ability to Bind Mycotoxins:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833486/)
L-Theanine Benefits:
https://pubmed.ncbi.nlm.nih.gov/16930802/#:~:text=Abstract,glutamate%20receptors%20in%20the%20brain
Keto Coffee:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221889/
Caffeine Consumption's Influence on Metabolic Health:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811484/
In this episode, I talk about Vitamin A and Why it's important, especially for gut health. I also shed some light on why you might want to look a little bit more carefully at your vitamin A supplement and multivitamin. Lastly, I give insights into the best whole food sources for Vitamin A, and how to get the most out of your supplementing.
References:
Vitamin A and Carotenoids:
Understanding the role of vitamin A and its precursors in the immune system:
https://www.sciencedirect.com/science/article/pii/S0985056221002156#bib1045
Vitamin A and Muscle Growth in Cows:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934359/
Beef Liver Nutrition info:
https://fdc.nal.usda.gov/fdc-app.html#/food-details/1098653/nutrients
Bovine Colostrum and its benefits:
This episode looks into the types of hormones that we produce during a stress response and how they balance each other. At the end, I dive into thing we all can do to fine tune our stress response.
References:
“Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat” (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20261/)
CBZ's Role in the Body:
https://www.sciencedirect.com/science/article/pii/092241069190111T
Cortisol physiology: https://www.ncbi.nlm.nih.gov/books/NBK538239/#:~:text=The%20presence%20of%20glucocorticoids%2C%20such,gluconeogenesis%20and%20decrease%20glycogen%20synthesis
Cortisol and Light:
https://pubmed.ncbi.nlm.nih.gov/10487717/
Melatonin and Cortisol:
Cortisol's effect on balance and stress:
Pig Study on Hippocampus:
https://pubmed.ncbi.nlm.nih.gov/5784535/
What does our hippocampus do:
https://www.webmd.com/brain/hippocampus-what-to-know
Cortisol and Hippocampus Volume:
Cortisol and Blood Glucose Regulation:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185996/
How Many thoughts do we have in a day:
https://www.nature.com/articles/s41467-020-17255-9
OXTR Gene Variants and their effect on Empathy:
Dogs and Oxytocin:
Mindfulness and Cortisol levels:
https://pubmed.ncbi.nlm.nih.gov/23724462/
Wim Hof Antarctica Study:
https://pubmed.ncbi.nlm.nih.gov/35437052/
Yoga and Stress:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278216/
Yoga, Cortisol and Depression:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768222/
In this episode, I go into the mechanisms our body has to use fats for energy, before highlighting a few genes and potential supplement hacks we can use to help our body utilize fats better and avoid a keto crash.
Resources:
Fats and Cell Membranes: https://www.ncbi.nlm.nih.gov/books/NBK26871/#:~:text=Lipid%E2%80%94that%20is%2C%20fatty%E2%80%94,of%20a%20small%20animal%20cell
Brown Fat and Thermoregulation: https://my.clevelandclinic.org/health/body/24015-brown-fat
Ketogenesis Mechanism: https://ncbi.nlm.nih.gov/books/NBK554523/#:~:text=Certain%20tissues%20of%20the%20body,energy%20transport%20from%20fat%20stores
Ketogenesis Regulation: https://www.ncbi.nlm.nih.gov/books/NBK493179/#:~:text=Ketogenesis%20can%20be%20upregulated%20by,hormonal%20regulator%20of%20this%20process
L-Carnitine Supplementation in Male Vegetarians: https://pubmed.ncbi.nlm.nih.gov/25612929/
SLC22A5 and Primary Carnitine Deficiency: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436458/
Case Study, Korean Child with SLC22A5 Mutations: http://www.annclinlabsci.org/content/42/4/424.full
L-Carnitine Supplementation for Fatigue: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667465/#:~:text=Carnitine%20supplementation%20is%20actively%20used,fatigue%20%5B11%2C20%5D
L-Carnitine For Exercise, Meta-Analysis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628984/#B7-jfmk-06-00093
ACAT Gene Overview: https://medlineplus.gov/genetics/gene/acat1/
Effects of ACAT inhibitors: https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/cholesterol-acyltransferase#:~:text=Cholesterol%20acyltransferase%20(ACAT%3B%20EC%202.3,is%20allosterically%20activated%20by%20cholesterol. and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398989/
ACAT Dysfunction in Kidney Cells: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928137
Glucose metabolism/Glycolysis upregulation in cancer cells: https://www.sciencedirect.com/science/article/pii/S2452336417300420#:~:text=Cancer%20cells%20exhibit%20aerobic%20glycolysis,is%20termed%20the%20Warburg%20effect
TNF-a and ACAT: https://www.sciencedirect.com/science/article/pii/S002222752030804X
Omega-3's and Omega-6's effect on ACAT: https://cdnsciencepub.com/doi/abs/10.1139/o92-178?journalCode=bcb
Vitamin B5 and CoA: https://pubmed.ncbi.nlm.nih.gov/26443589/#:~:text=Pantothenate%20is%20vitamin%20B5%20and,of%20the%20tricarboxylic%20acid%20cycle
PKAN: https://www.nature.com/articles/s41467-018-06703-2
and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861153/
Compounds that can stimulate PANK: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364590/
Riboflavin's importance in the body overview:
Riboflavin Deficient Diet and Impact on Rats: https://aocs.onlinelibrary.wiley.com/doi/abs/10.1007/BF02535365
Riboflavin's effect on Lipid Metabolism: https://www.sciencedirect.com/science/article/pii/S0955286318312105
Dietary Sources of Riboflavin: https://www.hsph.harvard.edu/nutritionsource/riboflavin-vitamin-b2
This episode takes a deep dive into the mitochondria, electron transport chain, how we get carbohydrates from our cells into the mitochondria and some fascinating genes that impact energy and longevity.
Studies Referenced:
On Mitochondria:
Electron Transport chain:
PDH, PDK and Aerobic Training:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665109
PDH/PDC Cofactors:
Thiamine and PDH:
https://www.nature.com/articles/pr197371.pdf
PDH and Chronic Fatigue:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161229/
Thiamine and Endurance Training:
CoQ10 Biosynthesis Genes:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731490/
Organs with highest CoQ10 Concentrations:
Dietary Sources of CoQ10:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953254/
Anti-inflammatory mechanisms of CoQ10:
https://pubmed.ncbi.nlm.nih.gov/29421772/)
Effects of Acute CoQ10 Supplementation on Athletic Performance:
CoQ10 and German Athlete Power Study:
https://jissn.biomedcentral.com/articles/10.1186/1550-2783-10-24
Sirtuin Function:
Sirtuins as Regulators of Healthspan:
SIRT3 and Fasting:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563434/
SIRT1 Overexpression and Metabolic Dysfunction:
This episode explores how our cells create energy, why we need vitamins, and some factors that can impair our cells ability to create energy efficiently.
Articles used:
On Low grade inflammation:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932180/
Physiology of metabolism
https://www.ncbi.nlm.nih.gov/books/NBK546690/
ATP and inflammation:
Increased mito function when glycolysis is reduced: https://www.nature.com/articles/s41598-019-55296-3#:~:text=Glycolytic%20suppression%20results%20in%20upregulation,pathways%2C%20glycolysis%20and%20mitochondrial%20OXPHOS.
Curcumin and IL-6 inhibition
GSH/NAC protective against oxidative stress
https://pubmed.ncbi.nlm.nih.gov/33717929/
Fried foods, lipid peroxidation and inflammation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601460/
IL-6 and mitochondria function
TNF-a and mitochondrial function
IL-1 and mitochondria
https://www.nature.com/articles/s41590-020-0750-1#:~:text=Taken%20together%2C%20these%20results%20indicate,super%2Dcomplex%20formation%20in%20adipocytes.
In this episode, I cover the basics and the essential terminology relating to genetics and the environment.