In this episode, I go into the mechanisms our body has to use fats for energy, before highlighting a few genes and potential supplement hacks we can use to help our body utilize fats better and avoid a keto crash.
Resources:
Fats and Cell Membranes: https://www.ncbi.nlm.nih.gov/books/NBK26871/#:~:text=Lipid%E2%80%94that%20is%2C%20fatty%E2%80%94,of%20a%20small%20animal%20cell
Brown Fat and Thermoregulation: https://my.clevelandclinic.org/health/body/24015-brown-fat
Ketogenesis Mechanism: https://ncbi.nlm.nih.gov/books/NBK554523/#:~:text=Certain%20tissues%20of%20the%20body,energy%20transport%20from%20fat%20stores
Ketogenesis Regulation: https://www.ncbi.nlm.nih.gov/books/NBK493179/#:~:text=Ketogenesis%20can%20be%20upregulated%20by,hormonal%20regulator%20of%20this%20process
L-Carnitine Supplementation in Male Vegetarians: https://pubmed.ncbi.nlm.nih.gov/25612929/
SLC22A5 and Primary Carnitine Deficiency: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436458/
Case Study, Korean Child with SLC22A5 Mutations: http://www.annclinlabsci.org/content/42/4/424.full
L-Carnitine Supplementation for Fatigue: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667465/#:~:text=Carnitine%20supplementation%20is%20actively%20used,fatigue%20%5B11%2C20%5D
L-Carnitine For Exercise, Meta-Analysis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628984/#B7-jfmk-06-00093
ACAT Gene Overview: https://medlineplus.gov/genetics/gene/acat1/
Effects of ACAT inhibitors: https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/cholesterol-acyltransferase#:~:text=Cholesterol%20acyltransferase%20(ACAT%3B%20EC%202.3,is%20allosterically%20activated%20by%20cholesterol. and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398989/
ACAT Dysfunction in Kidney Cells: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928137
Glucose metabolism/Glycolysis upregulation in cancer cells: https://www.sciencedirect.com/science/article/pii/S2452336417300420#:~:text=Cancer%20cells%20exhibit%20aerobic%20glycolysis,is%20termed%20the%20Warburg%20effect
TNF-a and ACAT: https://www.sciencedirect.com/science/article/pii/S002222752030804X
Omega-3's and Omega-6's effect on ACAT: https://cdnsciencepub.com/doi/abs/10.1139/o92-178?journalCode=bcb
Vitamin B5 and CoA: https://pubmed.ncbi.nlm.nih.gov/26443589/#:~:text=Pantothenate%20is%20vitamin%20B5%20and,of%20the%20tricarboxylic%20acid%20cycle
PKAN: https://www.nature.com/articles/s41467-018-06703-2
and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861153/
Compounds that can stimulate PANK: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364590/
Riboflavin's importance in the body overview:
Riboflavin Deficient Diet and Impact on Rats: https://aocs.onlinelibrary.wiley.com/doi/abs/10.1007/BF02535365
Riboflavin's effect on Lipid Metabolism: https://www.sciencedirect.com/science/article/pii/S0955286318312105
Dietary Sources of Riboflavin: https://www.hsph.harvard.edu/nutritionsource/riboflavin-vitamin-b2